The @nkf-professionals.bsky.social podcast for this article was released today. Had a great time discussing this topic with Osama El Shamy and Susie Hu

www.kidney.org/podcasts/kid...

Was fun to be a part of this amazing session. Doing my best to rep the renal pathologists

6/10
Give me something clever to say

“I think of a smoldering AMR like a slowly growing leiomyoma/uterine fibroid. We don't use chemo and using it still might not stop its growth” by @changucanspare.bsky.social

My editorial on the importance of this study design with repeat bxs. Some questions cannot be answered otherwise.

acrjournals.onlinelibrary.wiley.com/doi/abs/10.1...

Someone needs to look at a maintenance dose of complement inhibitors. I believe this is essential if we want xenotransplantation to go anywhere

#NephJC

Yet C4d PTC deposition in ABO-incompatible transplants doesn't seem to result in bad outcomes so it's hard to wrap our heads around this complexity.

#NephJC

Definitely possible, but then does this result in overtreatment (if/when we have good treatment)?

I think of a smoldering AMR like a slowly growing leiomyoma/uterine fibroid. We don't use chemo and using it still might not stop its growth

#NephJC

I don't think we know. Presumably there are other non-HLA abs that also fix complement and trigger the same injury pathway