Christian Wood
@christianwood.bsky.social
Behavioural neuroscientist at University of Cambridge. Prefrontal cortex, cognition, emotion, psychiatric disorders
Finally, I just want to say thank you to everyone who contributed to this work and am exceedingly proud of our work together!
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August 28, 2025 at 8:30 AM
Finally, I just want to say thank you to everyone who contributed to this work and am exceedingly proud of our work together!
💊 Ketamine treatment restored the blunted motivation from inactivating Area 46. This restorative effect appears to act via Area 25, as direct ketamine infusion into the region also restored motivation.
August 28, 2025 at 8:30 AM
💊 Ketamine treatment restored the blunted motivation from inactivating Area 46. This restorative effect appears to act via Area 25, as direct ketamine infusion into the region also restored motivation.
We mapped the circuits within the prefrontal cortex that were involved:
🧠 Area 46 → Area 32 controlled motivation
🧠 Area 46 → ventral Area 32 controlled the response to threat
Direct connection with Area 25, itself a target for depression, had no effect.
🧠 Area 46 → Area 32 controlled motivation
🧠 Area 46 → ventral Area 32 controlled the response to threat
Direct connection with Area 25, itself a target for depression, had no effect.
August 28, 2025 at 8:30 AM
We mapped the circuits within the prefrontal cortex that were involved:
🧠 Area 46 → Area 32 controlled motivation
🧠 Area 46 → ventral Area 32 controlled the response to threat
Direct connection with Area 25, itself a target for depression, had no effect.
🧠 Area 46 → Area 32 controlled motivation
🧠 Area 46 → ventral Area 32 controlled the response to threat
Direct connection with Area 25, itself a target for depression, had no effect.
Temporarily inactivating Area 46 in marmosets:
⚡️Reduced motivation to work for rewards (anhedonia-like)
⚡️Increased reactivity to threats (anxiety-like)
Effects that appear specific to the left hemisphere of the brain.
⚡️Reduced motivation to work for rewards (anhedonia-like)
⚡️Increased reactivity to threats (anxiety-like)
Effects that appear specific to the left hemisphere of the brain.
August 28, 2025 at 8:30 AM
Temporarily inactivating Area 46 in marmosets:
⚡️Reduced motivation to work for rewards (anhedonia-like)
⚡️Increased reactivity to threats (anxiety-like)
Effects that appear specific to the left hemisphere of the brain.
⚡️Reduced motivation to work for rewards (anhedonia-like)
⚡️Increased reactivity to threats (anxiety-like)
Effects that appear specific to the left hemisphere of the brain.