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Reposted

The Francis Crick Institute @crick.ac.uk · 19h

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Reposted

Lucia Prieto Godino @neuroluci.bsky.social · 1d

We are recruiting PhD students! If you are interested in evolutionary neuroscience, consider applying: www.crick.ac.uk/careers-stud...

Prieto Godino Lab | Cellular and molecular bases of neural circuit and behavioural evolution

www.crick.ac.uk

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Reposted

Richard Benton @bentonlab.bsky.social · 4d

Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …

www.biorxiv.org/content/10.1...

A GPCR signaling pathway in insect odor detection

Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs), and insects, which employ ion channels. Here, we report the first evidence for a GPCR defining tunin...

www.biorxiv.org

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Reposted

Greg Jefferis @jefferis.bsky.social · 4d

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Male CNS Connectome

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

www.janelia.org

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Reposted

Ana Marija Jakšić @merianelion.bsky.social · 9d

🚨Preprint🚨
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images

www.biorxiv.org/content/10.1...

Figure showing 3 panels. Panel A: workflow of a classical deep learning model vs TopoTome workflow, with marked differences between the methods, including manual segmentation of images, design and optimization of neural network and data post processing that is needed in deep learning workflow but not in TopoTome. Panel B: core concepts behind TopoTome shown connected by arrows. From left to right, there is a microCT scan of a fly brain (3D reconstruction), a persistence barcode of H2 homologies, an image of how persistent barcodes map to the original CT brain scan, and a segmentation of a CT scan. Panel C shows the concept of cubical complex filtration of 2D and 3D image data.

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Reposted

Daniel Kronauer @danielkronauer.bsky.social · 20d

The final version of our paper on how ants and possibly other insects use a crazy mechanism involving extensive transcriptional interference to regulate odorant receptor expression is now open access in my favorite journal, @currentbiology.bsky.social

authors.elsevier.com/sd/article/S...

ScienceDirect.com | Science, health and medical journals, full text articles and books.

authors.elsevier.com

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Reposted

The Rockefeller University @rockefeller.edu · 20d

A new study in ants from @danielkronauer.bsky.social reveals a previously unknown mechanism that ensures that each olfactory neuron expresses only one odorant receptor, with broad implications for the study of gene regulation. #RockefellerScience
https://bit.ly/4pwPFLY

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Reposted

Emmanuel Perisse @manuperisse.bsky.social · 24d

You just finished your PhD and you are looking for a postdoc to study stress-dependent modulation of learning. We are using the powerful fly model to understand the underlying circuits and mechanisms. You can apply here:
emploi.cnrs.fr/Offres/CDD/U...

Portail Emploi CNRS - Offre d'emploi - Postdoc position (M/F) in Neuroscience, stress modulation of learning (H/F)

emploi.cnrs.fr

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Reposted

Greg Jefferis @jefferis.bsky.social · Aug 21

Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
#preprint thread ⬇️1/8

ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.

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Reposted

Dr. Or M. Bialik |📚|🔬|🌊|⚒️ @obialik.bsky.social · Aug 17

Some behaviors are genetic, not learned, which means, theoretically, that they are transferable.
That is exactly what this experiment demonstrated. Manipulation of one gene made one species of fruit fly gain the behavior of another. 🧪

Link: www.science.org/doi/10.1126/...

Drosophila subobscura males regurgitate food and offer it as a gift to females during courtship

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Reposted

Lucia Prieto Godino @neuroluci.bsky.social · Aug 13

Thank you @thetransmitter.bsky.social and @martajhill.bsky.social for highlighting our work!

The Transmitter @thetransmitter.bsky.social · Aug 1

Some parts of the Drosophila olfactory circuit have evolved more than others, according to a new comparison of two fruit fly species’ connectomes.

By @martajhill.bsky.social

#neuroskyence

www.thetransmitter.org/connectome/c...

Cross-species connectome comparison shows uneven olfactory circuit evolution in flies

The findings start to reveal evolutionary changes that may have helped two species develop different olfactory preferences and adapt to their particular environments.

www.thetransmitter.org

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Reposted

Katrin Vogt @katrinvogt.bsky.social · Aug 12

Exciting new paper from the Bahl lab @bahllab.bsky.social @zwitscherarmin.bsky.social and Katja Slangewal about parallel and convergent processing pathways of different visual features in the larval zebrafish brain🐟
www.biorxiv.org/content/10.1...

Parallel and convergent pathways for multifeature visual processing in larval zebrafish sensorimotor decision-making

Animals continuously extract and evaluate diverse sensory information from the environment to guide behavior. Yet, how neural circuits integrate multiple, potentially conflicting, inputs during decisi...

www.biorxiv.org

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Reposted

The Transmitter @thetransmitter.bsky.social · Aug 1

Some parts of the Drosophila olfactory circuit have evolved more than others, according to a new comparison of two fruit fly species’ connectomes.

By @martajhill.bsky.social

#neuroskyence

www.thetransmitter.org/connectome/c...

Cross-species connectome comparison shows uneven olfactory circuit evolution in flies

The findings start to reveal evolutionary changes that may have helped two species develop different olfactory preferences and adapt to their particular environments.

www.thetransmitter.org

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Reposted

Wei-Chung Allen Lee @darbly.bsky.social · Aug 3

With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.

Preprint: doi.org/10.1101/2025...

#Neuroscience #Connectomics #vEM #VectorBiology 🧪

Diagrams (top-left) of an adult female Ae. aegypti head and (bottom) a basiconic sensillum on maxillary palp (gray) which contain dendritic processes of olfactory sensory neurons (OSNs), including CO2-sensitive Gr3-expressing OSNs. OSN axons project centrally to the antennal lobes in the brain. On the right is a volumetric rendering of the mosquito brain neuropils including the antennal lobes (light blue) (Heinze et al., 2021; Matthews et al., 2019). Scale bar 100 μm.

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Reposted

Meg Younger @megyounger.bsky.social · Jul 31

New preprint from @darbly.bsky.social‬ @briandepasquale.bsky.social‬ and my labs! If you love (or hate) mosquitoes, have a look:

doi.org/10.1101/2025...

We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟

Recurrent connectivity supports carbon dioxide sensitivity in Aedes aegypti mosquitoes

The mosquito Aedes aegypti′s human host-seeking behavior depends on the integration of multiple sensory cues. One of these cues, carbon dioxide (CO2), gates odorant and heat pathways and activates hos...

doi.org

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Reposted

Felix Baier @felixbaier.bsky.social · Jul 23

🚨Very happy that my PhD work is now out in @nature.com!

We discovered that evolution, by acting in the midbrain, shifted the threshold to escape in Peromyscus mice, to fine-tune defensive strategies in different environments

www.nature.com/articles/s41...

This was a truly collaborative effort! 🧵⬇️

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Katja Reinhard @katjareinhard.bsky.social · Jul 23

Finally it's out! www.nature.com/articles/s41... How flexible are essential innate behaviours and their underlying neural circuits? @felixbaier.bsky.social & I, with Hopi Hoekstra and @farrowlab.bsky.social, addressed this by studying the #evolution of threat avoidance in Peromyscus mice.

The neural basis of species-specific defensive behaviour in Peromyscus mice - Nature

Visual threat triggers contrasting freeze and escape defensive responses in two species of deer mice as a result of different activation thresholds downstream of the superior colliculus in the do...

www.nature.com

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Reposted

Kevin Mitchell @wiringthebrain.bsky.social · Jun 20

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae | Science www.science.org/doi/10.1126/... 😍

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

www.science.org

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Reposted

Nicholas Bellono @nbellono.bsky.social · Jun 17

Microbiomes shape our biology from gut-brain, skin, immunology, and more. Here, Rebecka Sepela et al explores octopus “taste by touch” sensation to ask how environmental microbiomes drive animal behavior. @cellpress.bsky.social, @mblscience.bsky.social
www.cell.com/cell/fulltex...

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christophgiez.bsky.social @christophgiez.bsky.social · Jun 12

Just dropped a new preprint! 🧠✨ We did some exciting comparative connectomics and uncovered new insights into how neural circuits evolve. Check it out 👇 #neuroscience #connectomics #preprint #evolution

Lucia Prieto Godino @neuroluci.bsky.social · Jun 12

How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇

bit.ly/44aVm9E

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Reposted

Christopher Noack @chnoack.bsky.social · Jun 6

I am excited to share our new publication in @pnas.org on the de novo nerve net assembly in Hydra embryos showing that neural circuits self-assemble through activity-driven processes, modulated by temperature and the microbiome. Thanks to all colleagues involved here! www.pnas.org/doi/10.1073/...

Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by temperature and the microbiome | PNAS

Understanding how neural populations emerge to give rise to behavior is a major goal in neuroscience. Here, we explore the self-assembly of neural ...

www.pnas.org

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Reposted

tomtom-auer.bsky.social @tomtom-auer.bsky.social · Apr 28

Happy to see this out now:
Olfactory projection neuron rewiring in the brain of an ecological specialist: Cell Reports www.cell.com/cell-reports...

In a team effort with @bentonlab.bsky.social 's lab we establish new genetic tools in #drosophila sechellia and compare single central brain neurons.

Olfactory projection neuron rewiring in the brain of an ecological specialist

Dürr et al. develop advanced genetic tools in the host specialist D. sechellia to study its olfactory system neuroanatomy. They show via single-cell labeling, tracing, and quantitative comparison of o...

www.cell.com

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Reposted

Michael Winding @michael-winding.bsky.social · Apr 12

We are looking for a motivated and meticulous laboratory research scientist (LRS) to help with a comprehensive neuronal inactivation screen. This is a great opportunity to build experience in the growing field of experimental connectomics. Apply by 2 May!
crick.wd3.myworkdayjobs.com/External/job...

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