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Charalampos Tzoulis

@chtzoulis.bsky.social

18 followers 12 following 3 posts

Professor of Neurology and Neurogenetics | Parkinson's disease Researcher | Clinical Trialist | Humanist & Science Advocate

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Charalampos Tzoulis @chtzoulis.bsky.social · May 15

Our latest work provides insights into the cell-specific gene expression landscape of Parkinson's disease (PD), PD caused by LRRK2 mutations, and multiple system atrophy (MSA). We also explore signatures associated with α-syn pathology: url:https://academic.oup.com/brain/article/148/5/1588/7901271

Charalampos Tzoulis @chtzoulis.bsky.social · Apr 30

Fresh from our lab - Analyses of muscle biopsies from persons with Parkinson's disease indicate the existence of a subgroup with impaired mitochodrial function. Another step towards biological stratification of PD: www.nature.com/articles/s43...

Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson’s disease - Communications Medicine

Kverneng et al. assess the mitochondrial respiratory chain in skeletal muscle from persons with Parkinson’s disease. Their findings suggest the existence of a subpopulation with complex I deficiency a...

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Charalampos Tzoulis @chtzoulis.bsky.social · Apr 26

Check out our latest opinion paper on NAD augmentation as a disease-modifying strategy for neurodegeneration in Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

NAD augmentation as a disease-modifying strategy for neurodegeneration

Neurodegenerative diseases (NDDs) pose a significant and rapidly growing global health challenge, but there are no effective therapies to delay or halt progression. In recent years augmentation of nic...