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Ciça Canesso

@cicacanesso.bsky.social

430 followers 210 following 25 posts

Assistant Professor at @Einsteinmed Passionate about Mucosal Immunology

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....

Identification of antigen-presenting cell–T cell interactions driving immune responses to food

The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

www.science.org

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Reposted by Ciça Canesso

Mari Sosa @marisosa.bsky.social · 17d

The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.

Sosa Lab

www.sosaneurolab.com

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Ciça Canesso @cicacanesso.bsky.social · 21d

Thank you Arien!

Ciça Canesso @cicacanesso.bsky.social · 22d

Incredible honored to receive this award! Thank you Blavatnik and New York Academy of Science

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Reposted by Ciça Canesso

Roham Parsa @rohamparsa.bsky.social · Aug 29

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

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Ciça Canesso @cicacanesso.bsky.social · May 28

Welcome to this amazing community!

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

Ciça Canesso @cicacanesso.bsky.social · May 3

Congrats Mari!! Amazing! 🎉

Ciça Canesso @cicacanesso.bsky.social · Feb 13

Congrats Rachel! Welcome to NY!

Reposted by Ciça Canesso

The Rockefeller University @rockefeller.edu · Feb 5

Rockefeller's @cicacanesso.bsky.social talks to The Scientist about her recent work with @danmucida.bsky.social and @victora.bsky.social on how cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

How Does the Gut Immune System Distinguish Between Friends and Foes?

Cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

www.the-scientist.com

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Ciça Canesso @cicacanesso.bsky.social · Dec 22

Thank you Ivan!

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

Thank you Terri!

Ciça Canesso @cicacanesso.bsky.social · Dec 21

Thank you Sohail!

Ciça Canesso @cicacanesso.bsky.social · Dec 21

Thank you so much!

Reposted by Ciça Canesso

Sarah Ross @sarahhross.bsky.social · Dec 19

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

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Reposted by Ciça Canesso

Ranit Kedmi @kedmiranit.bsky.social · Dec 20

Congrats @cicacanesso.bsky.social. It is becoming clear that tolerance is generated by antigen-specific cellular network.

Sarah Ross @sarahhross.bsky.social · Dec 19

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

Thank you Ranit! It was very insightful to discuss all of this with you!

Ciça Canesso @cicacanesso.bsky.social · Dec 21

and to our collaborators Daria Esterházy, Mengze Lyu, Greg Sonnenberg, Tian-Tian Liu and Ken Murphy!

Ciça Canesso @cicacanesso.bsky.social · Dec 21

Huge thanks to my mentors @danmucida.bsky.social and @victora.bsky.social and my colleagues Tiago Bruno, Sandra Nakandakari-Higa, Ainsley Lockhart, Julia Luehr, Juliana Bortolatto, @rohamparsa.bsky.social, Bernardo Reis...

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

This division of labor between different APC subsets in the presentation of luminal antigens represents at least one cellular mechanism that helps us survive eating!

Ciça Canesso @cicacanesso.bsky.social · Dec 21

Our findings reveal a compartmentalized system in which presentation of dietary vs pathogen-derived antigens is accomplished by distinct APC subsets, likely as a mechanism to prevent food-specific Th2 responses even amid strong type-2 immunity driven by helminth infection.

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

Surprisingly, these inflammatory cDC2s did not engage in dietary antigen presentation and thus failed to induce differentiation of diet-specific Th2 cells, avoiding food allergy development.

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

We found that S.v. infection impairs oral tolerance induction by excluding tolerogenic APCs from antigen presentation to food-specific CD4+ T cells, while inducing a large population of inflammatory cDC2s, which promote Th2 responses.

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Ciça Canesso @cicacanesso.bsky.social · Dec 21

We previously discovered that infection with the helminth Strongyloides venezuelensis (S.v.) prevents Treg and oral tolerance induction. With this information in hand, we asked what happens to the APCs presenting dietary antigens during concomitant helminth infections.

Ciça Canesso @cicacanesso.bsky.social · Dec 21

Using this new platform, we found that in healthy conditions, cDC1s and Rort+ APCs are both associated with dietary antigen presentation and tolerance to food. However, during intestinal infection the picture changes…

Ciça Canesso @cicacanesso.bsky.social · Dec 21

To tackle this, we adapted LIPSTIC technology to directly identify, characterize, and locate APCs presenting food antigen in vivo. This allowed us to pinpoint which cells regulate food-specific tolerance vs inflammation.

Ciça Canesso @cicacanesso.bsky.social · Dec 21

There are many different types of APCs and if you think about the high density and diversity of luminal antigens constantly present in the gut, identifying which APC directs a specific immune response in the intestine is highly challenging.