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claudele.bsky.social
Claudèle Lemay-St-Denis
@claudele.bsky.social
70 followers 120 following 5 posts
Postdoc @haifaresearch.bsky.social w/ Rachel Kolodny | Biochem PhD from @umontreal.ca 🇨🇦 | Protein evolution 🧬 | Climate activist 🌍, vegan foodie 🍉 and hiking enthusiast 🏞 | she/her
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claudele.bsky.social
Claudèle Lemay-St-Denis @claudele.bsky.social · 1d
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@bentallab.bsky.social @soichirotsuda.bsky.social
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claudele.bsky.social
Claudèle Lemay-St-Denis @claudele.bsky.social · 1d
How does catalysis emerge from non-catalytic domains?

In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.

A striking case of catalysis evolving from binding.
molbioevol.bsky.social
Molecular Biology and Evolution @molbioevol.bsky.social · 6d
@claudele.bsky.social et al. studied the fundamental question of how enzymatic activity emerges by focusing on type B dihydrofolate reductases, suggesting DfrB domains evolved rudimentary catalysis from a binding capacity.

🔗 doi.org/10.1093/molbev/msaf215

#evobio #molbio
From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance
Abstract. How does enzymatic activity emerge? To shed light on this fundamental question, we study type B dihydrofolate reductases (DfrB), which were disco
doi.org
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Reposted by Claudèle Lemay-St-Denis
itaiyanai.bsky.social
Itai Yanai @itaiyanai.bsky.social · Mar 24
Night science is all about facilitating the import and export of ideas between scientists. Today at the workshop in Tel Aviv University we encouraged an open mind and an improvisational attitude to enthusiastically apply ‘night science’ thinking tools to our problems. 🙏 @judithberman11.bsky.social
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claudele.bsky.social
Claudèle Lemay-St-Denis @claudele.bsky.social · Mar 23
Hi! I would love to participate, but the link says the registration has ended? Is it still possible to register?
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claudele.bsky.social
Claudèle Lemay-St-Denis @claudele.bsky.social · Mar 23
Hi! I would love to participate, but the link says the registration has ended?
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claudele.bsky.social
Claudèle Lemay-St-Denis @claudele.bsky.social · Feb 4
Super cool! Bravo 👏🧬
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