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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles
@cnuevotapioles.bsky.social
300 followers 470 following 13 posts
Mitochondrial biology and cancer ••• Postdoctoral fellow at NYU Langone Grossman School of Medicine. Emerald Foundation Inc. Fellow. Leading Edge Fellow 2024 |Philips lab| +she/her+
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Dec 20
I am really happy to share that our last work from the Philips lab is now out in Cell Reports! The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A. www.cell.com/cell-reports...
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
Kochen Rossi et al. performed proximity labeling using the two splice variants of KRAS and defined their differential interactomes. Among the KRAS4A-specific interactors is BIRC6, a large member of the inhibitor of apoptosis proteins. BIRC6 co-localizes with KRAS4A on the Golgi and mono- and di-ubiquitinates KRAS4A but not KRAS4B.
www.cell.com
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Aug 22
I am honored to have received an Early Stage Investigator award and the opportunity to present my work on mitochondrial biology in Costello Syndrome at the 9th International RASopathies Symposium. I am grateful for the chance to discuss science and life’s challenges with everyone at this meeting.
rasnet.bsky.social
RASopathies Network @rasnet.bsky.social · Aug 19
The 9th International #RASopathies Symposium brought together a really fantastic group of participants & attendees. Inspiring to see the new generation coming up.
PRIORITY1️⃣Repositioning therapeutics developed for RAS-ERK signaling in oncology for the mosaic & syndromic RASopathy conditions 🙏
🧪
a group of students and postdocs receiving award certificates for their highly significant poster abstract submissions on the opening night of the RASopathies conference in 2025 A graphic describing the Ninth International RASopathies Symposium post-symposium number of attendees, sponsors, advocacy partners, etc.
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · May 28
Welcome to the amazing @leadingedgeprogram.bsky.social !!!
leadingedgeprogram.bsky.social
Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27
We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows
Text reads "Congratulations to the 2025 Leading Edge Fellows" followed by the Leading Edge logo and www.leadingedgesymposium.org. Below are the headshots and names of the 40 new Leading Edge Fellows. They are Cel Welch Lianna Wat Maria Toro Moreno Sarah Talley Xulu Sun Ines Sturmlechner Virginia Savy Amelie Raz Kali Pruss Caterina Profaci Sarah Pierce Melissa Pamula Kehinde Odufowora Patricia Nano Ariana Musa de Aquino Nour El Houda Mimouni Kathleen Martin Brea Manuel Mable Lam Miri Krupkin Elaine Kouame Megan Kirchgessner Sumin Kim Shubhangini Kataruka Geraldine Jowett Andrea Jones Leanne Iannucci Emily Heckman Allison Girasole Florencia Fernandez Chiappe Tonie Farris Hannah Elam Erin Doherty Xiaoyun Ding Maria Bustillo Julia Brunner Debadrita Bhattacharya Lorena Benedetti Ashley Anderson Krisha Aghi
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Jan 13
Applications are still open for the 2025 Leading Edge cohort! Deadline is Feb 3, 2025.
leadingedgeprogram.bsky.social
Leading Edge Fellows Program @leadingedgeprogram.bsky.social · Jan 6
Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊

Learn more about them:
www.leadingedgesymposium.org/fellows/

Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).

You do NOT need to be ready for the job market to apply.
Headshots of 102 women and non-binary scientists who are now assistant professors. At the bottom is the Leading Edge logo and www.leadingedgesymposium.org
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Dec 20
I would like to thank our collaborators for making this work possible, as well as the other two co-authors of this work Juan Kochen Rossi and Rachel O’Keefe. It would have been impossible to find a better group of people to work with!!
cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Dec 20
BIRC6 co-localizes with KRAS4A on the Golgi and mono- and diubiquitinates KRAS4A but not KRAS4B. We found that BIRC6 is required for sustained GTP loading and maximal proliferative activity of KRAS4A.
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Dec 20
Here, we defined the differential interactomes of KRAS splice variants using proximity labeling. Among the KRAS4A specific interactors we found BIRC6, a large member of the inhibitor of apoptosis proteins.
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Dec 20
I am really happy to share that our last work from the Philips lab is now out in Cell Reports! The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A. www.cell.com/cell-reports...
The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A
Kochen Rossi et al. performed proximity labeling using the two splice variants of KRAS and defined their differential interactomes. Among the KRAS4A-specific interactors is BIRC6, a large member of the inhibitor of apoptosis proteins. BIRC6 co-localizes with KRAS4A on the Golgi and mono- and di-ubiquitinates KRAS4A but not KRAS4B.
www.cell.com
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Reposted by Cristina Nuevo-Tapioles
richpossemato.bsky.social
Rich Possemato @richpossemato.bsky.social · Nov 26
I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV
https://www.nature.com/articles/s42255-024-01166-w
t.co
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 23
Maybe it’s worth trying a second purification of the mitochondrial pellet using a sucrose gradient then m.cshprotocols.cshlp.org/content/2014.... But I understand that it is challenging to get very pure mitochondrial samples!!
Cold Spring Harb Protoc | Mobile
m.cshprotocols.cshlp.org
cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 22
It might depend on the final use of the mitochondria but a classic method that is still my favorite is this one: www.sciencedirect.com/science/arti...
Isolation of mitochondria for biogenetical studies: An update
The use of good quality preparations of isolated mitochondria is necessary when studying the mitochondrial biogenetical activities. This article expla…
www.sciencedirect.com
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 22
Very cool and inspiring lecture tonight from the Nobel Laureate
@ardemp.bsky.social organized by The Harvey Society. I’m definitely a PIEZO fan now!
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 17
You can find more about my research here: scholar.google.com/citations?us...
Cristina Nuevo Tapioles
‪Perlmutter Cancer Center. NYU Langone Health‬ - ‪‪Cited by 800‬‬ - ‪Cancer Biology‬ - ‪Cell Biology‬ - ‪Mitochondria‬
scholar.google.com
cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 17
One of my main goals is to elucidate the differences of the KRAS splice variants, so I believe this recent review offers valuable insights into some of my research interests www.frontiersin.org/journals/cel...
Frontiers | The role of KRAS splice variants in cancer biology
The three mammalian RAS genes (HRAS, NRAS and KRAS) encode four proteins that play central roles in cancer biology. Among them, KRAS is mutated more frequent...
www.frontiersin.org
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cnuevotapioles.bsky.social
Cristina Nuevo-Tapioles @cnuevotapioles.bsky.social · Nov 17
Hola Bluesky! 🌟
My name is Cristina, and I am a postdoctoral fellow in the Philips lab at NYU School of Medicine. During my PhD, I trained as a mitochondrial biologist, and I am currently exploring the fascinating role of this dynamic organelle in cancer and rare disorders.
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Reposted by Cristina Nuevo-Tapioles
leadingedgeprogram.bsky.social
Leading Edge Fellows Program @leadingedgeprogram.bsky.social · Nov 10
If you want to follow awesome women and non-binary early career scientists, the starter pack of Leading Edge Fellows is here!

go.bsky.app/He3EAcq
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