The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

Image-based approaches to single-cell transcriptomics offer the exciting ability to directly image gene expression at the transcriptome scale within intact tissue slices, defining, discovering, and ma...

Shen et al. introduce SpaTrack, which integrates cell transcriptomics and spatial position using optimal transport to reconstruct cell differentiation trajectories. SpaTrack is applied to disentangle ...