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David MacPherson Lab

@davidmacphersonlab.bsky.social

1K followers 200 following 9 posts

Cancer Biologist at Fred Hutchinson Cancer Center. Our lab studies the biology of small cell lung cancer.

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David MacPherson Lab @davidmacphersonlab.bsky.social · Nov 17

Hello Bluesky! I’m a Professor at Fred Hutch and our lab studies the biology of small cell lung cancer. Using mouse and PDX models, cell-based and in vivo genetic screens, and genomic approaches, we seek to understand biologically distinct subsets of SCLC and their therapeutic vulnerabilities.

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Reposted by David MacPherson Lab

Fred Hutch @fredhutch.org · May 15

In work published in Science Advances, researchers in the @davidmacphersonlab.bsky.social used #CRISPRCas9 on #SCLC tumor cells to better model how tumors that initially respond to chemotherapy become resistant. www.fredhutch.org/en/news/cent...

Fred Hutch study finds genetic driver of drug resistance in small cell lung cancer

A study of human tumor cells implanted in mice from the MacPherson Lab at Fred Hutch describes a new way to screen for the genes that matter in chemotherapy resistance in small cell lung cancer.

www.fredhutch.org

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David MacPherson Lab @davidmacphersonlab.bsky.social · Apr 29

Not a small part! Thanks to you and Noah for such a fantastic collaboration

David MacPherson Lab @davidmacphersonlab.bsky.social · Apr 29

This work was jointly led by graduate students Lauren Brumage and Scott Best @fredhutch.bsky.social. Grateful for key collaborators including @barzin-nabet.bsky.social, @lucasbsullivan.bsky.social as well as reviewers and editors at Science Advances and funding from the NCI and Fred Hutch 2/2

David MacPherson Lab @davidmacphersonlab.bsky.social · Apr 29

Our latest, in Science Advances: In vivo CRISPR screen revealed sgRNAs that switch chemosensitive SCLC PDXs to become resistant.We validated KEAP1 as key hit and found KEAP1 alterations in IMpower133 trial, where active NRF2 links to reduced survival in chemo arm www.science.org/doi/10.1126/... 1/2

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David MacPherson Lab @davidmacphersonlab.bsky.social · Dec 4

Postdoc salaries at FH follow a WA state law for exempt employees - big jumps in salary coming this jan 2025 and in 2 years

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David MacPherson Lab @davidmacphersonlab.bsky.social · Dec 3

The MacPherson lab at Fred Hutch is hiring a postdoc to study the biology of small cell lung cancer. We employ in vivo models, genetic screens and genomic approaches to understand + therapeutically target subsets of SCLC. $78K salary ⬆️ to >$90K after 2 yrs
careers-fhcrc.icims.com/jobs/28757/p...