Paul is running for Congress because there’s a sickness in Washington, and no one is working to cure it.

Abstract. Two-dimensional drawing of nucleic acid structures, particularly RNA structures, is fundamental to the communication of nucleic acids research. H

Nature Communications - tRNAs contain many chemical modifications that regulate their function. Integrating smFRET and cryo-EM approaches, this work demonstrates that m1G37 in tRNAProL stabilizes...

tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...

Cancer cells frequently enhance ribosome production to support rapid growth. Here, Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved element (CRNDEUCE) promotes 60S r...

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Researchers from the Tanenbaum group have developed a new microscopy technique to observe how ribosomes function in cells.

Hwang et al. identify TRMT1L as the elusive methyltransferase responsible for catalyzing the m22G modification at position 27 on tyrosine tRNA. TRMT1L is also crucial for maintaining acp3U and D modifications on select tRNAs, and its depletion reduces tyrosine tRNA stability, global translation efficiency, and cell survival under oxidative stress.