Jonne Sikkens
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dewittehi.bsky.social
Jonne Sikkens
@dewittehi.bsky.social
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Internist acute medicine & infectious diseases, interested in clinical reasoning, General internal medicine, statistics/epidemiology, POCUS, research. Also MSc in clinical epi & neuropsychology
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Reposted by Jonne Sikkens
sailorrooscout.bsky.social
Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics.

The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...
ABSTRACT Lasso peptides (biologically active molecules with a distinct structurally constrained knotted fold) are natural products that belong to the class of ribosomally synthesized and post-translationally modified peptides. Lasso peptides act on several bacterial targets but none have been reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell. Here we report the identification and characterization of the lasso peptide antibiotic lariocidin and its internally cyclized derivative lariocidin B, produced by Paenibacillus sp. M2, which has broad-spectrum activity against a range of bacterial pathogens. We show that lariocidins inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis. Structural, genetic and biochemical data show that lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16S ribosomal RNA and aminoacyl-tRNA, inhibiting translocation and inducing miscoding. Lariocidin is unaffected by common resistance mechanisms, has a low propensity for generating spontaneous resistance, shows no toxicity to human cells, and has potent in vivo activity in a mouse model of Acinetobacter baumannii infection. Our identification of ribosome-targeting lasso peptides uncovers new routes towards the discovery of alternative protein-synthesis inhibitors and offers a novel chemical scaffold for the development of much-needed antibacterial drugs. Lariocidin, a lasso-shaped peptide with promising antibiotic properties. (Graphic: Dmitrii Travin and Yury Polikanov). Research: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.
March 31, 2025 at 4:01 PM
Reposted by Jonne Sikkens
drk-lo.bsky.social
🧪👨‍🔬 #rstats
Guy: "me learning R". Guy whistling at hot girl labeled "Ggplot2 with custom themes". Guy is holding hand with girlfriend labeled "proper data cleaning"
December 22, 2024 at 8:46 PM