Lightnews — Scholar-powered news

Reposted by Kevin Pruitt

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 15d

Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!

Photo of @dr-kevin-pruitt.bsky.social standing in front of slides from the podium where he gave a seminar at the Van Andel Institute.

4 8 93

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 2d

Thanks!!

1

Reposted by Kevin Pruitt

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 5d

Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉

2 3 20

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 4d

Beautiful

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 5d

Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉

2 3 20

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 6d

Congrats 🎊👏

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 8d

Awesome pic!!

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 11d

Very best birthday wishes! Amazing cake!

1 1

Reposted by Kevin Pruitt

Kevin Pruitt @dr-kevin-pruitt.bsky.social · Jul 16

For years, we searched for factors which are dysregulated in cancer and regulate development. We now describe elusive roles of DVL, a protein co-opted in #cancer and mutated in congenital disorders thanks to lab members & support from @unclineberger.bsky.social & @unc-phco.bsky.social
rdcu.be/ewwsZ

Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor

Nature Communications - Currently, nuclear roles for DVL1 and its involvement in gene regulation remained unclear. Here the authors reveal that altering DVL1 expression significantly reshapes gene...

rdcu.be

3 14 74

Reposted by Kevin Pruitt

Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 12d

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

5 14 41

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 12d

Beautiful!

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 12d

Several factors contribute. A major factor is mutation of the adenomatous polyposis coli (APC) gene. APC suppresses tumor growth, but when mutated, its function is compromised. This can lead to intestinal polyps, which can start off benign, but additional mutations can transform them into cancer.

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 12d

Congrats!

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 13d

Thanks!!

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 13d

Congrats!!

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 13d

Would love to be added when time permits. Thanks for creating it!!

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

Wow!

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

Beautiful

1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

No worries, I'm sure we'll cross paths soon. Hope you and the lab members are doing well.

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

Thank you! Yes, it was so good seeing you, and best wishes as you continue to get the lab established.

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

some level. Also, this pathway controls cell motility, which if disrupted promotes cancer metastasis. So, understanding Wnt signaling is important for both in human development and increasing the likelihood we can successfully target the dysregulated aspects of signaling for cancer therapies.

1 2

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

this signaling network controls cell proliferation. During the process of cancer progression, the Wnt signaling pathway can become co-opted or hijacked and the normal regulation of cell proliferation is perturbed. For example in more than 80% of colon cancers, Wnt signaling is dysregulated at

1 1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

a flow of biological information (ie signaling) that regulates iconic developmental processes. If this flow of information is diminished or is excessive, it can lead to many different types developmental disorders. What’s also interesting about these Wnt ligands that bind to their receptors is that

1 1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 14d

Great question! Wnt signaling is term that describes the flow of biological “information” in a cell or in organs. For example, a Wnt ligand can bind to specific sets of receptors on the surface of cells throughout tissues and organs in the body. This Wnt binding to its receptor then initiates

1 1

Kevin Pruitt @dr-kevin-pruitt.bsky.social · 15d

Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!

4 8 93