Hagop Kantarjian, M.D.
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drhkantarjian.bsky.social
Hagop Kantarjian, M.D.
@drhkantarjian.bsky.social
55 followers 16 following 20 posts
Leukemia professor & chair @mdanderson.bsky.social
Unable to provide medical advice here; contact the clinic, or call 877-632-6789 for an appointment. Views are mine.
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drhkantarjian.bsky.social
Out in @Ajhematology: Relapse mechanisms after frontline FLT3 inhibitor therapy in FLT3 #AML include FLT3 loss and emergent non-FLT3 mutations. Post-relapse outcomes are poor, especially in FLT3 mut relapses.
@mdanderson.bsky.social #Leukemia
doi.org/10.1002/ajh....
#leusm
September 2, 2025 at 5:00 PM
drhkantarjian.bsky.social
Please check our recent Seminar review in @thelancet.com discussing the biology of #ALL and evolution of treatment for both pediatric and adult patients
@mdanderson.bsky.social #Leukemia
www.thelancet.com/journals/lan...
#leusm
August 5, 2025 at 4:30 PM
drhkantarjian.bsky.social
There have been major advances in #ALL therapy over the last decade. Check out our review just published in Cancer Journal
discussing these advances & revolution in adult ALL therapy.
@mdanderson.bsky.social #Leukemia
doi.org/10.1002/cncr...
#leusm
doi.org
July 29, 2025 at 8:16 PM
drhkantarjian.bsky.social
SQ blinatumomab is highly effective in R-R ALL with CR/CRh rate of 77%, MRD-negativity rate of 91%, and 12-month OS rate of 63-70%.

The 250 µg/500 µg dose was selected as the recommended phase 2 dose.
@mdanderson.bsky.social
#Leukemia
doi.org/10.1016/s235...
#leusm
July 15, 2025 at 5:52 PM
drhkantarjian.bsky.social
A comprehensive review on the management of #CML in 2025 written by an international group of CML experts.
@mdanderson.bsky.social #Leukemia
doi.org/10.1002/cncr...
#leusm
Management of chronic myeloid leukemia in 2025
Chronic myeloid leukemia (CML) management has evolved significantly with BCR::ABL1 tyrosine kinase inhibitors (TKIs), which has reduced annual mortality to 1% and will increase prevalence to more tha...
doi.org
July 7, 2025 at 1:48 PM
drhkantarjian.bsky.social
WBC >70K (but not IKZF1plus) increases risk of relapse with blina+ponatinib in Ph+ ALL, particularly extramedullary/CNS. Pts with high WBC should be considered for systemic MTX/Ara-C and/or CAR T-cell consolidation
@mdanderson.bsky.social
jhoonline.biomedcentral.com/articles/10....
#leusm #ALL
May 15, 2025 at 2:25 PM
drhkantarjian.bsky.social
New in Leukemia Journal: Outcomes in intensively treated KMT2Ar #AML have improved over time. But low-intensity therapies still show poor results — highlighting the urgent need to explore menin inhibitors
www.nature.com/articles/s41...
#leusm
@mdanderson.bsky.social
May 13, 2025 at 5:40 PM
drhkantarjian.bsky.social
Historical development, current status, and future research of olverembatinib, a new third-generation BCR::ABL1 TKI with significant activity and favorable safety profile:
@mdanderson.bsky.social #Leukemia
dx.doi.org/10.1002/cncr...
#leusm #CML
Olverembatinib in chronic myeloid leukemia—Review of historical development, current status, and future research
Chronic myeloid leukemia is typically effectively managed with BCR::ABL1 tyrosine kinase inhibitors (TKIs) but treatment resistance and intolerance are persistent challenges. Olverembatinib is a thir...
dx.doi.org
April 15, 2025 at 5:53 PM
drhkantarjian.bsky.social
First report of the Ph 2 trial of the CLIA regimen in pts w/ R/R #AML: CR/CRi of 49% & median OS of 12 months in pts who received it as 1st salvage rx. Data provides tolerable & effective backbone upon which to build combination strategies @mdanderson.bsky.social
doi.org/10.1002/cncr...
April 15, 2025 at 3:14 PM
drhkantarjian.bsky.social
Ph 1b/2 trial of Aza-Ven-Magro in newly-diagnosed high-risk and R/R #AML: Clinical data & correlative analysis @theaacr.bsky.social
doi.org/10.1158/1078...
Unfortunately, the neg Ph3 ENHANCE trials terminates research w/ Magrolimab and likely anti-CD47 Rx in AML for now
@mdanderson.bsky.social
Azacitidine, Venetoclax and Magrolimab in Newly Diagnosed and Relapsed Refractory Acute Myeloid Leukemia: Phase 1b/2 Study and Correlative Analysis
Abstract. Purpose: Magrolimab is a monoclonal antibody directed against macrophage checkpoint CD47 on myeloid leukemia cells that was pre-clinically synergistic with azacitidine-venetoclax, warranting...
doi.org
April 11, 2025 at 7:11 PM
drhkantarjian.bsky.social
Check out our comprehensive review on #AML from an @mdanderson.bsky.social perspective, " Therapeutic horizon of acute myeloid leukemia: Success, optimism, and challenges" published in @acsjournalcancer.bsky.social

acsjournals.onlinelibrary.wiley.com/doi/10.1002/...
#leusm
April 1, 2025 at 1:16 PM
drhkantarjian.bsky.social
Check out our comprehensive review of Chronic Myeloid Leukemia published in @jama.com
Listen to our interview available through the link:
jamanetwork.com/journals/jam...
@mdanderson.bsky.social #Leukemia
@ EJabbour @drhkantarjian.bsky.social
#leusm #CML
Review of Chronic Myeloid Leukemia
This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia.
jamanetwork.com
March 20, 2025 at 3:25 PM
drhkantarjian.bsky.social
In this large retrospective study of FLT3-mutated AML, we confirm the important role of FLT3 inhibitors in intensively treated pts and demonstrate promising outcomes w/ low-intensity triplets in older/unfit pts
@mdanderson.bsky.social #Leukemia
@americancancersoc.bsky.social doi.org/10.1002/cncr...
March 19, 2025 at 4:51 PM
drhkantarjian.bsky.social
Expert recommendations on using MRD in #ALL now out in @bloodadvances.bsky.social. ClonoSEQ (NGS MRD) is superior to other MRD methods and should guide decisions about CAR T-cells or SCT
@mdanderson.bsky.social #Leukemia
doi.org/10.1182/bloo...
#leusm
March 18, 2025 at 2:40 PM
drhkantarjian.bsky.social
Oral formulation of arsenic trioxide has similar pharmacokinetics to the intravenous drug, allowing potential future all oral therapy in acute promyelocytic leukemia
@mdanderson.bsky.social #Leukemia
doi.org/10.1182/bloo...
@ash.hematology.org
#leusm
March 14, 2025 at 2:47 PM
drhkantarjian.bsky.social
Updated results of our frontline trial of FLAG-IDA+VEN, showing CRc in 95% of newly diagnosed #AML. Responses were seen across all ELN22 risk groups, w/ 90% MRD neg. In RR AML, 79% first salvage & TP53wt attained CRc.
@mdanderson.bsky.social
rdcu.be/ebcvm
#leusm
February 25, 2025 at 7:36 PM
drhkantarjian.bsky.social
Treatment-free remission in non-transplanted Ph+ #ALL pts is feasible in carefully selected pts. Those in CR1 (n=6) who maintained CMR for >48 mos did not relapse following TKI discontinuation.
@mdanderson.bsky.social
doi.org/10.1002/cncr...
@nitinjainmd.bsky.social @niranjankhaire.bsky.social
February 24, 2025 at 10:32 PM
drhkantarjian.bsky.social
Early attainment of undetectable MRD by MFC is independently associated w/ improved RFS in newly diagnosed #AML. Intermediate risk pts who attain undetectable MRD should still undergo consolidative allo-SCT.
@mdanderson.bsky.social #Leukemia
@ash.hematology.org
ashpublications.org/bloodadvance...
February 17, 2025 at 3:14 PM
drhkantarjian.bsky.social
Genomic secondary #AML: Heterogenous group w/ outcomes variable based on presence of secondary type mutations or cytogenetics
@mdanderson.bsky.social #Leukemia Kantarjian, DiNardo, Loghavi, Senapati @jayastumd.bsky.social American Journal of Hematology onlinelibrary.wiley.com/doi/10.1002/...
#leusm
Clinico‐Genomic Interrogation of Secondary‐Type Acute Myeloid Leukemia: Response and Outcomes to Contemporary Therapies
Outcomes of patients with secondary-type acute myeloid leukemia.
onlinelibrary.wiley.com
February 14, 2025 at 11:08 PM
drhkantarjian.bsky.social
Treated secondary #AML is an adverse subtype of AML that warrants an independent prognostic designation
@mdanderson.bsky.social #Leukemia
Kantarjian, Kadia, Senapati, @jayastumd.bsky.social
American Journal of Hematology
onlinelibrary.wiley.com/doi/10.1002/...
#leusm
February 14, 2025 at 11:05 PM