Jimmy Lee
@drjimmylee.bsky.social
140 followers 150 following 9 posts
Senior Data Scientist - Bayraktar Group @sangerinstitute.bsky.social Instagram: Sanger2Helmholtz
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drjimmylee.bsky.social
📢 @bayraktarlab.bsky.social & colabs at @sangerinstitute.bsky.social are assembling the @opentargets.org funded Neuroimmune Team 🧠🧬-Leverage AI to uncover neurodegeneration

Tech Spec: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
Postdoc AI: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
drjimmylee.bsky.social
Very excited to see this work comes out ad preprint! An elegant strategy discovering novel recessive signals in Exome sequencing dataset of the British South Asian population 🧬
#bioinformatics #exome #DNA #datascience #genomics #genetics
drjimmylee.bsky.social
Amazing work and congratulations Lisa! We have a project asking exactly this question, so would definitely give it a try!!
Reposted by Jimmy Lee
lisasikkema.bsky.social
Analyzing your single-cell data by mapping to a reference atlas? Then how do you know the mapping actually worked, and you’re not analyzing mapping-induced artifacts? We developed mapQC, a mapping evaluation tool www.biorxiv.org/content/10.1... from the ‪@fabiantheis lab. Let’s dive in🧵
drjimmylee.bsky.social
Amazing work by the GBM-SPACE team atlassing one of the deadliest cancers #glioblastoma at multimodality, & coupled the elegant scDORI framework.
These studies reveal a high-resolution spatiotemporal cell trajectory from tumour heterogeneity & plasticity at both cellular and molecular levels
bayraktarlab.bsky.social
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
drjimmylee.bsky.social
Ever wondered what a snapshot of single-cell/spatial dataset can reveal?
scCellFie - a scalable tool that goes beyond gene expression, making metabolic analysis possible
3-2-1, Say GENES 🤳
PREPRINT: doi.org/10.1101/2025...
DOWNLOAD: sccellfie.readthedocs.io
#DataScience #Bioinformatics #Spatial
Reposted by Jimmy Lee
humancellatlas.org
We are delighted to announce a new collaboration between HCA and @UNESCO.org to help advance open science, global capacity and ethical frameworks to deliver the benefits of genomics at a global scale.

www.humancellatlas.org/news/the-hum...
drjimmylee.bsky.social
Absolutely over the moon to share our COVID-19 study is now featured on
@naturecomms.bsky.social
Editors’ Highlights for Microbiology & Infectious Diseases! Huge thanks to
Sonja Schmid for choosing our work as one of the 50 BEST papers in this field. 💡Check it out: www.nature.com/collections/...
Reposted by Jimmy Lee
josiebryant.bsky.social
If you have experience in sc/spatial transcriptomics with an interest in microbes....come and join our team as a computational postdoc:
sanger.wd103.myworkdayjobs.com/WellcomeSang...

Incredibly exciting datasets on host-microbe interactions in the lung.

Pls RT and reach out if you are interested.
Postdoctoral Fellow - Computational
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
drjimmylee.bsky.social
Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage 🫁.
Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org
sangerinstitute.bsky.social
How lung damage worsens during COVID-19 has been mapped at a cellular level. 🦠

By understanding how our lungs respond to the virus over time, this new knowledge may help identify future therapies for COVID-19.

www.sanger.ac.uk/news_item/ce...
Cellular changes as lung damage worsens in COVID-19 revealed
Researchers uncover cellular changes as damage to alveoli in the lungs progresses during COVID-19.
www.sanger.ac.uk
drjimmylee.bsky.social
Absolutely Amazing!!
mariabrbic.bsky.social
Thrilled to share LUNA🌕 – our new generative AI model that reassembles tissue structures from dissociated cells! LUNA learns spatial priors over existing spatially resolved datasets with the aim to predict cell locations de novo.

Check out our paper here: www.biorxiv.org/content/10.1...
drjimmylee.bsky.social
It was a pleasure to give a talk at the #HCA2024Asia @humancellatlas.org meeting. I really enjoyed catching up with some @sangerinstitute.bsky.social alumni and had some fascinating discussions with amazing scientists!!

#HumanCellAtlas #Neuroscience #SingleCell #Bioinformatics