Eleni Louka
@ellouka.bsky.social
Reposted by Eleni Louka
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
December 8, 2025 at 10:10 PM
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Eleni Louka
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
December 6, 2025 at 12:59 AM
ONLINE FIRST ALERT!
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
aacrjournals.org/bloodcancerd...
@aacrjournals.bsky.social
#childhoodcancer
#epigenetics
#precisiononcology
Reposted by Eleni Louka
#ScientistSpotlight: This week we’re introducing Verena Körber, one of the newest Group Leaders at the MRC WIMM.
@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk
@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk
November 18, 2025 at 9:43 AM
#ScientistSpotlight: This week we’re introducing Verena Körber, one of the newest Group Leaders at the MRC WIMM.
@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk
@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk
Reposted by Eleni Louka
NEW: Oxford scientists have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease.
Crohn’s disease affects around 1 in every 650 people.
Crohn’s disease affects around 1 in every 650 people.
Oxford scientists map the cells that drive Crohn’s disease fistulas,
Scientists at the University of Oxford, have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30%
www.ox.ac.uk
November 17, 2025 at 1:48 PM
NEW: Oxford scientists have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease.
Crohn’s disease affects around 1 in every 650 people.
Crohn’s disease affects around 1 in every 650 people.
Reposted by Eleni Louka
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Eleni Louka
Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩
"For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social
"For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social
November 5, 2025 at 4:50 PM
Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩
"For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social
"For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social
Reposted by Eleni Louka
Each October, we host our Director's Welcome Breakfast to introduce our newest members to the MRC WIMM and all that it has to offer - from cutting-edge facilities to friendly support networks for students, postdocs, parents and carers 🧬🤝
📽️Learn more about the MRC WIMM in our new intro video 👇
📽️Learn more about the MRC WIMM in our new intro video 👇
Introducing the MRC WIMM at the University of Oxford
YouTube video by MRC Weatherall Institute of Molecular Medicine
youtu.be
October 21, 2025 at 8:44 AM
Each October, we host our Director's Welcome Breakfast to introduce our newest members to the MRC WIMM and all that it has to offer - from cutting-edge facilities to friendly support networks for students, postdocs, parents and carers 🧬🤝
📽️Learn more about the MRC WIMM in our new intro video 👇
📽️Learn more about the MRC WIMM in our new intro video 👇
Reposted by Eleni Louka
NEW @cancerresearchuk.org-funded study, led by @bethpsaila.bsky.social & @l-cmurphy.bsky.social, reveals an unexpected and powerful new function for platelets with profound implications for cancer diagnosis and prenatal screening 🧪
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Learn more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Learn more 👇
Platelets Shown to Store DNA in Study that could Transform Cancer Screening
Study led by Psaila Group uncovers previously unknown function of platelets as DNA ‘vacuum cleaners’ in the blood, with profound implications for cancer diagnosis and prenatal screening.
www.imm.ox.ac.uk
August 15, 2025 at 9:12 AM
NEW @cancerresearchuk.org-funded study, led by @bethpsaila.bsky.social & @l-cmurphy.bsky.social, reveals an unexpected and powerful new function for platelets with profound implications for cancer diagnosis and prenatal screening 🧪
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Learn more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Learn more 👇
Reposted by Eleni Louka
Huge thanks to @cancerresearchuk.org for funding and sparking the key collabs, co-authors @imm.ox.ac.uk @ox.ac.uk @ludwigcancer.bsky.social @edinburghuni.bsky.social and all who provided feedback along the way @Grc @ash.hematology.org @isehsociety.bsky.social @sarahhross.bsky.social
The "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer News
Our scientists have discovered that platelets are swelling with information which could help us detect cancers earlier.
news.cancerresearchuk.org
August 15, 2025 at 5:37 AM
Huge thanks to @cancerresearchuk.org for funding and sparking the key collabs, co-authors @imm.ox.ac.uk @ox.ac.uk @ludwigcancer.bsky.social @edinburghuni.bsky.social and all who provided feedback along the way @Grc @ash.hematology.org @isehsociety.bsky.social @sarahhross.bsky.social
Reposted by Eleni Louka
'[...]analysis of platelets can potentially improve screening tests, including for cancer.'
@bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer.
www.oxcode.ox.ac.uk/news/platele...
@bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer.
www.oxcode.ox.ac.uk/news/platele...
Platelets shown to store DNA in study that could transform cancer screening
Oxford-led study uncovers previously unknown function of platelets as DNA ‘vacuum cleaners’ in the blood, with profound implications for cancer diagnosis and prenatal screening.
www.oxcode.ox.ac.uk
August 18, 2025 at 10:50 AM
'[...]analysis of platelets can potentially improve screening tests, including for cancer.'
@bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer.
www.oxcode.ox.ac.uk/news/platele...
@bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer.
www.oxcode.ox.ac.uk/news/platele...
Reposted by Eleni Louka
Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight
August 15, 2025 at 5:37 AM
Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight
Reposted by Eleni Louka
Check out our latest publication in @science.org, showing that platelets are a source of tumour DNA!
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
August 15, 2025 at 9:34 AM
Check out our latest publication in @science.org, showing that platelets are a source of tumour DNA!
Reposted by Eleni Louka
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
August 14, 2025 at 6:35 PM
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
📖 Read our paper here: doi.org/10.1126/sci...
🎬 Watch a summary: youtu.be/MttCA3GGWEM
🧵 Or keep reading for the key points! 🔑 1/19
Reposted by Eleni Louka
NEW: Researchers at the MRC WIMM and @dkfz.bsky.social have developed a new method to analyse how our tissues evolve as we age, called SCIFER 🧬 🧪
Read more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Read more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
New tool allows researchers to track how mutations arise in tissues
Researchers at the MRC Weatherall Institute of Molecular Medicine and the German Cancer Research Center (DKFZ) have developed a new method to analyse how our tissues evolve as we age.
www.imm.ox.ac.uk
July 3, 2025 at 9:28 AM
NEW: Researchers at the MRC WIMM and @dkfz.bsky.social have developed a new method to analyse how our tissues evolve as we age, called SCIFER 🧬 🧪
Read more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Read more 👇
@rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk
Reposted by Eleni Louka
WIMM Day 2025 brought our researchers together to share discoveries, swap ideas & celebrate success — from gene editing to immunotherapy to public engagement.
Catch the recap + award winners here:
Catch the recap + award winners here:
Celebrating science, collaboration and excellence at WIMM Day 2025
The MRC WIMM community gathered for its flagship annual event, WIMM Day, on Tuesday 24th June. Held at the Saïd Business School, the day showcased the breadth and impact of research across the institu...
www.imm.ox.ac.uk
July 1, 2025 at 10:41 AM
WIMM Day 2025 brought our researchers together to share discoveries, swap ideas & celebrate success — from gene editing to immunotherapy to public engagement.
Catch the recap + award winners here:
Catch the recap + award winners here:
Reposted by Eleni Louka
We're hiring at Oxford!
Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs).
🔬 Apply here:
my.corehr.com/pls/uoxrecru...
🔍 Learn about our research:
imm.ox.ac.uk/research/res...
#AcademicJobs #Haematology #MPN #Oxford
Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs).
🔬 Apply here:
my.corehr.com/pls/uoxrecru...
🔍 Learn about our research:
imm.ox.ac.uk/research/res...
#AcademicJobs #Haematology #MPN #Oxford
Job Details
my.corehr.com
May 26, 2025 at 1:16 PM
We're hiring at Oxford!
Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs).
🔬 Apply here:
my.corehr.com/pls/uoxrecru...
🔍 Learn about our research:
imm.ox.ac.uk/research/res...
#AcademicJobs #Haematology #MPN #Oxford
Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs).
🔬 Apply here:
my.corehr.com/pls/uoxrecru...
🔍 Learn about our research:
imm.ox.ac.uk/research/res...
#AcademicJobs #Haematology #MPN #Oxford
Reposted by Eleni Louka
NEW: Researchers at the MRC Molecular Haematology Unit, led by @ckbrierley.bsky.social & @adammead.bsky.social, have uncovered a potential new therapeutic target in BP-MPN - a particularly aggressive type of leukaemia.
🧪🧬
Read more:
@oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk
🧪🧬
Read more:
@oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk
New research reveals druggable target arising from chromosomal rearrangement in aggressive leukaemia
Researchers at the University of Oxford have uncovered a potential new therapeutic target in a particularly aggressive and hard-to-treat form of leukaemia.
www.imm.ox.ac.uk
June 10, 2025 at 9:06 AM
NEW: Researchers at the MRC Molecular Haematology Unit, led by @ckbrierley.bsky.social & @adammead.bsky.social, have uncovered a potential new therapeutic target in BP-MPN - a particularly aggressive type of leukaemia.
🧪🧬
Read more:
@oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk
🧪🧬
Read more:
@oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk
Reposted by Eleni Louka
We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below
March 27, 2025 at 7:59 AM
We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below
Reposted by Eleni Louka
For International Women's Day tomorrow, we asked some of our female scientists, including @agoriely.bsky.social & @sumanasharma.bsky.social, to reflect on why this day is so important, the barriers and biases women can face in their careers, and which women have inspired them.
#IWD2025
#IWD2025
International Women's Day at the MRC WIMM
YouTube video by MRC Weatherall Institute of Molecular Medicine
youtu.be
March 7, 2025 at 12:10 PM
For International Women's Day tomorrow, we asked some of our female scientists, including @agoriely.bsky.social & @sumanasharma.bsky.social, to reflect on why this day is so important, the barriers and biases women can face in their careers, and which women have inspired them.
#IWD2025
#IWD2025
Reposted by Eleni Louka
To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪
Rare Disease Day 2025: Paediatric Leukaemias
YouTube video by MRC Weatherall Institute of Molecular Medicine
youtu.be
February 28, 2025 at 10:28 AM
To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪
Reposted by Eleni Louka
Preprint alert: this was a wonderful collaborative project with Prof Karadimitris @imperialcollegeldn.bsky.social and many others. Thanks to all and especially @cancerresearchuk.org for the CAYP innovation award funding. All feedback welcome!
Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease
Current therapies, including autologous CAR-T immunotherapy, fail to cure half of infants with KMT2A-rearranged acute lymphoblastic leukemia (KMT2Ar-ALL). Here we deploy allogeneic iNKT cells, innatel...
www.biorxiv.org
January 25, 2025 at 2:46 PM
Preprint alert: this was a wonderful collaborative project with Prof Karadimitris @imperialcollegeldn.bsky.social and many others. Thanks to all and especially @cancerresearchuk.org for the CAYP innovation award funding. All feedback welcome!
Reposted by Eleni Louka
NEW: @ineosoxford.bsky.social has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under five years of age.
More info ⬇️
More info ⬇️
Wellcome Discovery Award of £5m to fund pioneering research to combat
The Ineos Oxford Institute has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under
www.ox.ac.uk
January 17, 2025 at 2:42 PM
NEW: @ineosoxford.bsky.social has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under five years of age.
More info ⬇️
More info ⬇️
Reposted by Eleni Louka
Celebrating Excellence in Medical Sciences Division 2024
Massive congratulations to our elected Academy of Medical Sciences fellows
#ExcellenceInOxfordMedSci2024
medsci.ox.ac.uk/news/academy...
Massive congratulations to our elected Academy of Medical Sciences fellows
#ExcellenceInOxfordMedSci2024
medsci.ox.ac.uk/news/academy...
December 20, 2024 at 3:38 PM
Celebrating Excellence in Medical Sciences Division 2024
Massive congratulations to our elected Academy of Medical Sciences fellows
#ExcellenceInOxfordMedSci2024
medsci.ox.ac.uk/news/academy...
Massive congratulations to our elected Academy of Medical Sciences fellows
#ExcellenceInOxfordMedSci2024
medsci.ox.ac.uk/news/academy...
Reposted by Eleni Louka
In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇
We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too!
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
Godinho Lab
www.godinholab.com
December 12, 2024 at 7:29 AM
In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇
Reposted by Eleni Louka
Had the best time at #ASH24 presenting with Simone Riva our work at the @imm.ox.ac.uk with Prof. Adam Mead and Prof. Jim Hughes on the construction of a novel multi-omic resource atlas for human granulopoiesis and the identification of molecular machinery underlying IMiD-induced neutropenia.
December 10, 2024 at 4:54 PM
Had the best time at #ASH24 presenting with Simone Riva our work at the @imm.ox.ac.uk with Prof. Adam Mead and Prof. Jim Hughes on the construction of a novel multi-omic resource atlas for human granulopoiesis and the identification of molecular machinery underlying IMiD-induced neutropenia.