Evan Irving-Pease
@evanirvingpease.bsky.social
620 followers 490 following 8 posts
Group Leader at the Big Data Institute, University of Oxford Royal Society University Research Fellow aDNA | Complex Traits | Selection | Disease | 🇦🇺🇬🇧💀🧬🦠
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evanirvingpease.bsky.social
Delighted to see our paper on the evolutionary history of the CCR5Δ32 deletion published this week in @cellpress.bsky.social. Work led by @ravnkirstine.bsky.social, Leonardo Cobuccio and Rasa Muktupavela, and co-supervised by me and @simorasmu.bsky.social. See 🧵 for main findings...
Graphical abstract: The chemokine receptor variant CCR5delta32 is linked to HIV-1 resistance and other conditions. Its evolutionary history and allele frequency (10%–16%) in European populations have been extensively debated. We provide a detailed perspective of the evolutionary history of the deletion through time and space. We discovered that the CCR5delta32 allele arose on a pre-existing haplotype consisting of 84 variants. Using this information, we developed a haplotype-aware probabilistic model to screen 934 low-coverage ancient genomes and traced the origin of the CCR5delta32 deletion to at least 6,700 years before the present (BP) in the Western Eurasian Steppe region. Furthermore, we present strong evidence for positive selection acting upon the CCR5delta32 haplotype between 8,000 and 2,000 years BP in Western Eurasia and show that the presence of the haplotype in Latin America can be explained by post-Columbian genetic exchanges. Finally, we point to complex CCR5delta32 genotype-haplotype-phenotype relationships, which demand consideration when targeting the CCR5 receptor for therapeutic strategies.
Reposted by Evan Irving-Pease
Reposted by Evan Irving-Pease
humanevouu.bsky.social
Application deadline in less than a week! Apply to join the Uppsala Human Evolution team!
Reposted by Evan Irving-Pease
trstngnthr.bsky.social
I have funding for a 2-year dry-lab postdoc to join our team @humanevouu.bsky.social 🧪 (Deadline Oct 21st)

The project will utilize modern and #aDNA data from humans and sheep to study environmental adaptation (including method development and simulations).

Please share!
www.uu.se/en/about-uu/...
Postdoctoral position in Population Genomics - Uppsala University
Postdoctoral position in Population Genomics, Department of Organismal Biology, Uppsala University
www.uu.se
Reposted by Evan Irving-Pease
jasminrees.bsky.social
1/ So pleased to share our paper on genetic adaptation to micronutrients in humans! Our biggest conclusion? Trace minerals in the diet have shaped human evolution far more than previously appreciated 🧬🌍👇
www.cell.com/ajhg/fulltex...
https://www.cell.com/ajhg/fulltext/S0002-9297(25)00315-5
t.co
Reposted by Evan Irving-Pease
tommyhigham.bsky.social
PhD Studentship alert!
I'm looking for a motivated student to work here in Vienna @vdsee-univie.bsky.social on my ERC grant "DISPERSE". It's a fulltime scholarship (working in 14C and #archsci in Palaeolithic archaeology in Eurasia.
Details in the link below!
jobs.univie.ac.at/job/Universi...
University assistant predoctoral 1
University assistant predoctoral 1
jobs.univie.ac.at
Reposted by Evan Irving-Pease
chasewnelson.bsky.social
Announcing SimHumanity, a baseline SLiM 5.0 model of the full human genome, replete with demographic history, autosomes, X/Y, and mtDNA. A shared starting point for reproducible evolutionary simulations. We’d love your feedback! #SLiM #evolution #genomics www.biorxiv.org/content/10.1...
SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution
The reconstruction of human evolutionary history has undergone repeated advances, each made possible by methodological innovations. In recent decades, genetic and genomic data played a central role in...
www.biorxiv.org
Reposted by Evan Irving-Pease
gingerhowley.bsky.social
I will be recruiting two PhDs for my ERC Project HERDPATH - let's discover out how livestock and pathogens evolved together using #aDNA. Projects will be animal or pathogen focused but will be in dialogue.

Details at my quaint website below. Deadline 3rd October.

kevingdaly.github.io
Ruminant Palaeogenomics - Kevin G. Daly: Ruminant Palaeogenomics
kevingdaly.github.io
Reposted by Evan Irving-Pease
sashagusevposts.bsky.social
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Beneath the surface of the sum
When genetic interactions matter and when they don't
open.substack.com
Reposted by Evan Irving-Pease
lauritsskov.bsky.social
Are you interested in doing a PhD in Copenhagen? Interested in studying Neanderthals and Denisovans which live on in our genomes?
Than you are more than welcome to apply to join my group starting Jan 2026 :)

candidate.hr-manager.net/ApplicationI...

Please reach out if you have any questions!
Reposted by Evan Irving-Pease
gingerhowley.bsky.social
Shameless promotion from #isba11 - I'll be hiring PhDs to start early 2026 (plus postdocs starting later), using #adna to study livestock and pathogen coevolution, particularly looking at inbreeding and immune gene evolution!

Contact me at kevin[at]palaeome.org, full ad to come. Please share!
Reposted by Evan Irving-Pease
mariosgeorgakis.bsky.social
I'm often asked how human genetic data can be used to validate drug targets.

In our new ‪@natcardiovascres.nature.com‬ paper, we provide an end-to-end framework for genetically validating IL-6 inhibition for atherosclerotic cardiovascular disease outcomes 🧵
Reposted by Evan Irving-Pease
fervillanea.bsky.social
Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!

This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).

www.science.org/doi/10.1126/...
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...
www.science.org
Reposted by Evan Irving-Pease
carlbergstrom.com
1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research.

This is wrong.

And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.
Reposted by Evan Irving-Pease
dgron.bsky.social
It's out! 😀

THE MAP: EXPANSION OF FARMING IN WESTERN EURASIA, 9600-4000 BCE
2025.1

Regional updates, particularly 🇺🇦. Colour and greyscale resolutions, and much asked for colour code and legend.

@barbarahorejs.bsky.social @leizarchaeology.bsky.social @oeai.bsky.social

zenodo.org/records/1688...
Reposted by Evan Irving-Pease
carlbergstrom.com
Will's detailed thread about using Claude Code as a coding assistant parallels my experience using ChatGPT o.3 and o.4 as a proof assistant.
wcratcliff.bsky.social
Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.
Reposted by Evan Irving-Pease
trstngnthr.bsky.social
The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:

www.uu.se/en/about-uu/...
Bioinformatician - Uppsala University
Bioinformatician, Department of Organismal Biology, Uppsala University
www.uu.se
Reposted by Evan Irving-Pease
sashagusevposts.bsky.social
I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:
What we talk about when we talk about risk
How embryo selection exploits our flawed intuitions about risk
open.substack.com
Reposted by Evan Irving-Pease
robp.bsky.social
🧬🖥️ I am strongly of the opinion that bioinformatics needs to move away entirely from text-based and "loosely" structured file formats for essentially any type of data. File formats should be binary-first, and designed for *correct* and *efficient* machine parsing 1/3
Reposted by Evan Irving-Pease
spaam-community.bsky.social
#MetagenomicsMonday Analysis of aDNA from 1313 ancient human remains spanning 37k years revealed that the rise of infectious diseases coincided with animal domestication around 65k years ago, with disease spread intensifying during pastoralist migrations.
www.nature.com/articles/s41...
The spatiotemporal distribution of human pathogens in ancient Eurasia - Nature
Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and zoonotic pathogens…
www.nature.com