We're sponsoring the use of ESM3 and EMSC to help researchers engineer improved PETase enzymes in the @AlignBio 2025 Protein Engineering Tournament.

Get started using ESMC to predict protein function and ESM3 to generate new enzymes here: github.com/evolutionary...

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🚀 Announcing the 2025 Protein Engineering Tournament.

This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️

#AIforBiology #ClimateTech #ProteinEngineering #OpenScience

Information about protein structure improves predictably with increasing training compute, demonstrating linear scaling across multiple orders of magnitude.

We overtrained ESM C 300M and 600M beyond the compute-optimal point predicted by the scaling curves.

Introducing ESM Cambrian, a new family of protein language models, focused on creating representations of the underlying biology of proteins.