Lightnews — Scholar-powered news

Gord Fishell @gordfishell.bsky.social · Aug 25

New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2

1 2 22

Gord Fishell @gordfishell.bsky.social · Jun 16

I am so excited about this combined analysis of the selective CRHR2 population within the lateral septum and how they control defensive behavior. Dionnet was truly a gifted graduate student. Keep your eyes on this one!

Dionnet L Bhatti Mazo @victoryofflight.bsky.social · Jun 16

Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧.

We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs.

www.researchsquare.com/article/rs-6...

Feature-specific threat coding in lateral septum guides defensive action

The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum...

www.researchsquare.com

1 10

Gord Fishell @gordfishell.bsky.social · Jun 14

At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice who gave an amazing talk this morning!

5

Gord Fishell @gordfishell.bsky.social · Jun 14

Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news-events/...

From the BRAIN Director: Q&A With Dr. Gordon Fishell and Dr. Bosiljka Tasic on Precise Brain Cell Delivery Systems | BRAIN Initiative

Newly published work funded by the NIH BRAIN Initiative offers a precision toolkit for accessing cells in the brain and spinal cord with unprecedented accuracy. The new delivery tools, about 1,000 in ...

braininitiative.nih.gov

3 21

Gord Fishell @gordfishell.bsky.social · Jun 3

So I open up the NYtimes and there is my pal @ardemp.bskyverified.social saying that despite funding cuts he is staying in this country that he loves. Keep the faith you all!.... www.nytimes.com/2025/06/03/u...

The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

www.nytimes.com

1 20 100

Gord Fishell @gordfishell.bsky.social · May 29

Wow quite the legends. Not to mention the white asparagus. Enjoy your fragrant pee dude!

1

Reposted by Gord Fishell

Salvatore Lacava @salvatorelacava.bsky.social · May 22

Gord Fishell @gordfishell.bsky.social · May 21

Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!

Neuron @cp-neuron.bsky.social · May 21

New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧

Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...

Explore the full issue here: www.cell.com/neuron/current

1 2

Reposted by Gord Fishell

Cell Press @cellpress.bsky.social · May 22

"Exploring brain circuits, one cell type—or more— at a time" www.cell.com/neuron/fullt...

Bosiljka Tasic & @gordfishell.bsky.social ‬
@cp-neuron.bsky.social

Exploring brain circuits, one cell type—or more— at a time

This issue of Neuron, with accompanying papers in Cell, Cell Genomics, Cell Reports, and Cell Reports Methods, contains studies describing methods for access to neuronal and non-neuronal cell types wi...

www.cell.com

1 4 9

Gord Fishell @gordfishell.bsky.social · May 21

Yep, glad people in europe are taking notice. Hey guys, we are having a giant fire sale! Top scientists looking for relocation to the other side of the pond. Sad!

Emma R Andersson @anderssonlab.bsky.social · May 1

Our recent paper in Science was co-led by @sandehaan.bsky.social, former PhD student in a @ki.se -NIH project. NIH support for international projects is transformative, seeding dynamic collaborations, and looks like it may stop. It is with great sorrow that I watch the dismantling of US science.

Magdalena Skipper @magdalenaskipper.bsky.social · May 1

NIH to suspend funds for research abroad as it overhauls policy - An exclusive story from the Nature News team

This NIH move threatens thousands of collaborative projects on infectious diseases, cancer and more
🧪 #AcademicSky #MedSky
@nature.com

www.nature.com/articles/d41...

1 4

Reposted by Gord Fishell

Stein Aerts @steinaerts.bsky.social · May 21

One thousand candidate enhancers tested in vivo in the mouse brain! A massive resource and oh so useful as validation set for genome-wide enhancer prediction methods. Super fun to be involved in one of the papers: ‘the prediction challenge paper’ by Nelson&Niklas et al www.cell.com/cell-genomic...

13 42

Gord Fishell @gordfishell.bsky.social · May 21

Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it!
urldefense.proofpoint.com/v2/url?u=htt...

urldefense.proofpoint.com

2 14 66

Gord Fishell @gordfishell.bsky.social · May 21

Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!

Neuron @cp-neuron.bsky.social · May 21

New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium. 🧠🔧

Read insights from Bosiljka Tasic & @gordfishell.bsky.social: www.cell.com/neuron/fullt...

Explore the full issue here: www.cell.com/neuron/current

9 34

Gord Fishell @gordfishell.bsky.social · May 15

Even though it is spring....it seems to have gotten dark lately...."Within the last several days, Harvard University has received letters from most federal agencies indicating that nearly all of HMS’s active, direct federal grants have been terminated."

1 2 12

Gord Fishell @gordfishell.bsky.social · May 6

There you are with my buddy Domingos!!!

1

Gord Fishell @gordfishell.bsky.social · May 4

You should write Kara directly or maybe just watch for it on Bluesky. For me this is a work in progress but I will post on Bluesky as I get involved.

1

Gord Fishell @gordfishell.bsky.social · May 4

I will fly to anywhere in the United States on my own dime to talk to people about basic science! I encourage all of you, particularly senior scientists to make this commitment. If you are looking for material ask @karalmarshall.bsky.social She has put together an amazing basic talk!

Gord Fishell @gordfishell.bsky.social · May 4

OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!

14 53

Gord Fishell @gordfishell.bsky.social · May 4

OK inspired by @karalmarshall.bsky.social I am reaching out to the public where ever I can. Traditionally Republicans have been incredibly supportive of science. We as scientists need to reach out to people across the spectrum to rally their support for basic science!

1 28

Gord Fishell @gordfishell.bsky.social · May 4

Ask Kara for this talk! It is an amazing walk through for the general public.mmI am going to give a general talk to the public every time I am traveling through the USA. I have had a wonderful career. It is my students and postdocs I am worried about 🥺. Come help out!

Kara Marshall @karalmarshall.bsky.social · May 3

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

YouTube video by Steve Lawson

youtu.be

1 13

Reposted by Gord Fishell

Kara Marshall @karalmarshall.bsky.social · May 3

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

YouTube video by Steve Lawson

youtu.be

17 77 270

Gord Fishell @gordfishell.bsky.social · May 3

Yes I know....I was hoping you guys would overlook the error!

1 1

Gord Fishell @gordfishell.bsky.social · May 3

Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness:
“The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”

3 24 110

Gord Fishell @gordfishell.bsky.social · May 2

Heads up: A ton of papers from my group at the Broad, Pittsburgh, Irvine, Caltech, Duke, Berkeley and especially the Allen are on deck for a big consortium publication on new methods to target range of specific neuronal and non-neuronal cells coming out in Neuron and associated journals May 20th!

4 49

Gord Fishell @gordfishell.bsky.social · Apr 22

Nuff said...https://www.harvard.edu/president/news/2025/the-promise-of-american-higher-education/

2

Gord Fishell @gordfishell.bsky.social · Apr 17

Ginty told me you independently made the same recommendation!

2

Gord Fishell @gordfishell.bsky.social · Apr 17

Color in the lines of your favorite proteins....can't wait to see David Ginty's full chest tattoo of a Pacinian corpsule!!!

Ardem Patapoutian @ardemp.bskyverified.social · Apr 16

Yes for Science tattoos!

Nature @nature.com · Apr 16

Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion

https://go.nature.com/42CnT65

1