Hannah Stacey
@hannahdstacey.bsky.social
Postdoc at the La Jolla Institute for Immunology | Studying mucosal immunology, influenza vaccines, antibody responses and B cells | PhD from McMaster University
Reposted by Hannah Stacey
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.
www.science.org
July 30, 2025 at 7:15 PM
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🚨 New preprint! We show that intranasal FluMist vaccination induces local HA-specific memory B cell responses in the upper airway, even in the absence of strong systemic responses. Investigating local immunity will be key to designing improved vaccines for respiratory pathogens.
In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans
Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...
www.biorxiv.org
July 21, 2025 at 11:08 PM
🚨 New preprint! We show that intranasal FluMist vaccination induces local HA-specific memory B cell responses in the upper airway, even in the absence of strong systemic responses. Investigating local immunity will be key to designing improved vaccines for respiratory pathogens.