Helen Chen
@hc327.bsky.social
120 followers 170 following 2 posts
#iPSC scientist & #organoids engineer for #RareDisease working on disease modeling & precision medicine. @StJudeResearch, @ubc alumnus🇨🇦
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Reposted by Helen Chen
kirkmcmanuslab.bsky.social
🚀 Exciting MSc opp @ UManitoba! Join 2 interdisciplinary labs (bioinformatics + cancer bio) on a CIHR-funded ovarian cancer project. Gain hands-on training in single-cell genomics & molecular biology. See advertisement to apply #GradResearch #Cancer
Reposted by Helen Chen
erichall.bsky.social
Great talk from @hc327.bsky.social at the 7th annual CCP Phenogenomics Conference! Dr Chen shows how rare disease foundations can really facilitate fantastic scientific progress directly helping patient families!
Reposted by Helen Chen
erichall.bsky.social
I still can't get over how cool cells can be reaching out and interacting with one another! This depth shaded membrane marker gives us an idea of how dynamic these extensions can be! #FluorescenceFriday 🔬🧪
hc327.bsky.social
Excited to share my latest paper from @stjuderesearch.bsky.social , where we leverage patient derived cortical organoids to study UBA5 associated neurodevelopmental disorders.
stjuderesearch.bsky.social
Scientists developed a patient-derived organoid model for UBA5-associated encephalopathy, revealing stunted GABAergic interneuron growth as a cause of seizures. Boosting activity of the hypomorphic UBA5 gene shows promise as a potential therapy.
Reposted by Helen Chen
erichall.bsky.social
Its FINALLY here! The first #FluorescenceFriday 🧪🔬out of the Hall lab! We're still in the process of optimizing different fixatives to look for cytonemes and cellular extensions, but a fantastic first time imaging them from Morgan Hiebert!
Reposted by Helen Chen
labogden.bsky.social
Despite all that is going on, I will not miss a #FluorescenceFriday! ✊ This is a confocal micrograph of a long cytoneme making contact with a recipient NIH3T3 cell (right) to deliver SHH ligand. The 🟣 dots are packages of SHH. Very cool! 🔬 by former postdoc @erichall.bsky.social. 🧪 #SciArt #DevBio
NIH3T3 cells with a long cytoneme contacting one of the cells to deliver a signal. The SHH ligand is in magenta, the SHH transport protein DISP is in red. Nuclei are blue. Green is the adhesion protein BOC.
Reposted by Helen Chen
labogden.bsky.social
Here is an early #FluorescenceFriday post - a 3D render of a developing mouse neural tube showing a signaling filopodium (cytoneme) reaching toward a primary cilium (green) to deliver a cellular signal (SHH, magenta). See alt text for details. Research supported by #NIH #NIGMS 🔬 by Eric Hall. 🧪
Reposted by Helen Chen
erichall.bsky.social
🧪🧑‍🔬 We are actively recruiting graduate students in the lab right now at UM!
If you are, or know a student looking to do cool research involving cell signaling, development, and 🔬, please share with your networks. For more information, checkout the link below.
rfhs.myjboard.io/jobs/1054626...
MSc or PhD Student Positions: Cytoneme mediated cell-cell communication in development and disease at Hall Lab
rfhs.myjboard.io
hc327.bsky.social
Great lab! Great opportunity! Highly recommend!
erichall.bsky.social
🧪🧑‍🔬 We are actively recruiting graduate students in the lab right now at UM!
If you are, or know a student looking to do cool research involving cell signaling, development, and 🔬, please share with your networks. For more information, checkout the link below.
rfhs.myjboard.io/jobs/1054626...
MSc or PhD Student Positions: Cytoneme mediated cell-cell communication in development and disease at Hall Lab
rfhs.myjboard.io
Reposted by Helen Chen
esbonkowski.bsky.social
The Mefford Lab is #hiring, come join us! @hcmefford.bsky.social

We have TWO positions open:

(1) *Lead Researcher/Scientist* who will have the opportunity to lead 2D and 3D #epilepsy #genetics modeling to inform better targeted treatments for kids. 🧠🧬💜

talent.stjude.org/careers/jobs...
Lead Researcher / Scientist - Mefford Lab in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Lead Researcher / Scientist - Mefford Lab in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org