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The Helix Brief @helixbrief.bsky.social · 10m

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The Helix Brief @helixbrief.bsky.social · 10m

This translatable strategy offers a promising approach for image-guided precision oncology.

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The Helix Brief @helixbrief.bsky.social · 10m

The platform allowed dynamic visualization of tumor penetration via NIR-II imaging and achieved deep tumor infiltration and suppressed tumor growth in a mouse model, bridging diagnostic certainty with therapeutic efficacy.

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The Helix Brief @helixbrief.bsky.social · 10m

The nanoparticles exhibited high drug loading, intense near-infrared II (NIR-II) fluorescence, and enhanced tumor accumulation due to the zwitterionic tertiary amine oxide (TAO) moiety.

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The Helix Brief @helixbrief.bsky.social · 10m

This research developed a multifunctional nanoparticle platform that combines a paclitaxel-polymer conjugate with aggregation-induced emission (AIE) luminogens.

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The Helix Brief @helixbrief.bsky.social · 10m

Innovative nanoconjugates with aggregation-induced emission enable real-time NIR-II imaging to guide transcytosis-driven cancer therapy, revolutionizing nanomedicine's clinical impact.

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Full analysis: https://helixbrief.com/article/cffacfc0-0c7e-4ffe-9ebf-5dbd2b2286a1

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The Helix Brief @helixbrief.bsky.social · 30m

📊 Research like this, explained daily

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The Helix Brief @helixbrief.bsky.social · 30m

The study's strength lies in its use of behaviour change theories and its collaborative approach, which aligns the implementation with the needs and preferences of clinicians, patients, and caregivers.

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The Helix Brief @helixbrief.bsky.social · 30m

These multifaceted strategies, encompassing various intervention functions and behaviour change techniques, aim to drive clinician adoption and ensure the app's seamless integration into routine practice.

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The Helix Brief @helixbrief.bsky.social · 30m

Using the Behaviour Change Wheel framework, the co-design team of 12 members held four iterative sessions to identify 11 tailored strategies targeting barriers and leveraging facilitators.

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The Helix Brief @helixbrief.bsky.social · 30m

This study employed a collaborative, theory-driven approach to develop implementation strategies for embedding a suicide safety planning app (the Hope App) into a Canadian psychiatric emergency department.

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The Helix Brief @helixbrief.bsky.social · 30m

Revolutionize suicide prevention with the Hope App! Co-designed with clinicians, patients, and caregivers, this innovative strategy harnesses the power of digital technology to seamlessly...

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Full analysis: https://helixbrief.com/article/65bb8985-416d-42c3-ace3-24794744a464

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The Helix Brief @helixbrief.bsky.social · 50m

📊 Research like this, explained daily

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The Helix Brief @helixbrief.bsky.social · 50m

These findings offer a blueprint for designing ferritin host-guest complexes with enhanced homogeneity and functionality, with potential applications in areas such as drug delivery and nanomedicine.

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The Helix Brief @helixbrief.bsky.social · 50m

This work provides the first example of cooperative assembly between a cargo protein and a ferritin capsule, and establishes a strategy for generating stoichiometric 1:1 protein host-guest complexes, as confirmed by time-resolved fluorescence anisotropy.

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The Helix Brief @helixbrief.bsky.social · 50m

Guided by molecular dynamics simulations and computational protein design, the researchers engineered supercharged variants of green fluorescent protein (GFP) and demonstrated that the charge magnitude and distribution of the cargo dictate the efficiency of capsule assembly and loading.

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The Helix Brief @helixbrief.bsky.social · 50m

This study explores the use of charge engineering to regulate the encapsulation of cargo proteins within self-assembling ferritin capsules.

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The Helix Brief @helixbrief.bsky.social · 50m

Harness the power of charge engineering to control the assembly and loading of protein host-guest complexes, unlocking new possibilities in supramolecular chemistry.

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Full analysis: https://helixbrief.com/article/f250f082-bfb4-44fe-8758-2150196b0452

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The Helix Brief @helixbrief.bsky.social · 1h

📊 Research like this, explained daily

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The Helix Brief @helixbrief.bsky.social · 1h

The findings provide insights into the mechanisms underlying cell division in S. aureus and have implications for understanding the action of β-lactam antibiotics.

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The Helix Brief @helixbrief.bsky.social · 1h

This tight regulation of Sle1 levels is crucial for maintaining the balance between peptidoglycan biosynthesis and hydrolysis, which is disrupted by β-lactam antibiotics, leading to their bactericidal effects.

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The Helix Brief @helixbrief.bsky.social · 1h

The researchers found that CxaR acts as an adaptor protein, facilitating the degradation of the peptidoglycan hydrolase Sle1 by the conserved ClpXP protease complex.

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The Helix Brief @helixbrief.bsky.social · 1h

This study used a genome-wide screen, sequencing of suppressor mutants, immunoblotting, and in vivo protein-protein interaction assays to uncover the role of the uncharacterized protein CxaR in controlling Staphylococcus aureus cell splitting.

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The Helix Brief @helixbrief.bsky.social · 1h

Discover how an adaptor protein, CxaR, regulates cell splitting in Staphylococcus aureus by facilitating the degradation of a key peptidoglycan hydrolase, Sle1, through the ClpXP protease...

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Full analysis: https://helixbrief.com/article/bcc9a590-4292-4770-8377-174b6650e5f4

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The Helix Brief @helixbrief.bsky.social · 1h

📊 Research like this, explained daily

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