JAMA Ophthalmology
@jamaophthalmology.bsky.social
JAMA Ophthalmology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
🌐 JAMAOphthalmology.com
🌐 JAMAOphthalmology.com
Pharmacologic inhibition of the Hippo signaling pathway via YAP/TEAD inhibitor therapy was associated with peripapillary chorioretinal atrophy similar to findings in inherited TEAD1-related disease. ja.ma/3XGCg7o
December 7, 2025 at 2:00 PM
Pharmacologic inhibition of the Hippo signaling pathway via YAP/TEAD inhibitor therapy was associated with peripapillary chorioretinal atrophy similar to findings in inherited TEAD1-related disease. ja.ma/3XGCg7o
This case series identified two distinct homozygous pathogenic variants in the EGFLAM gene among patients with complete congenital stationary night blindness (#CSNB) in two unrelated families. ja.ma/3Y8teAd
December 6, 2025 at 2:00 PM
This case series identified two distinct homozygous pathogenic variants in the EGFLAM gene among patients with complete congenital stationary night blindness (#CSNB) in two unrelated families. ja.ma/3Y8teAd
Inherited #RetinalDystrophy due to pathogenic SLC6A6 variants is linked to disrupted taurine transport and reduced plasma taurine in affected individuals.
ja.ma/4iDpxfx
ja.ma/4iDpxfx
https://ja.ma/48rZnrb
Early-onset retinopathy in patients with variants in SLC6A6, leading to impaired taurine transport
ja.ma
December 5, 2025 at 2:00 PM
Inherited #RetinalDystrophy due to pathogenic SLC6A6 variants is linked to disrupted taurine transport and reduced plasma taurine in affected individuals.
ja.ma/4iDpxfx
ja.ma/4iDpxfx
Six new consensus grading scales for #AdverseEvents provide standardized reporting and dosing guidance for ocular toxicity in experimental oncology drug trials.
ja.ma/4pKegw1
ja.ma/4pKegw1
December 4, 2025 at 4:30 PM
Six new consensus grading scales for #AdverseEvents provide standardized reporting and dosing guidance for ocular toxicity in experimental oncology drug trials.
ja.ma/4pKegw1
ja.ma/4pKegw1
Case report: occlusion of the retinal vessels following intravitreal injection of aflibercept, 8.0 mg, in a woman with neovascular age-related macular degeneration. ja.ma/48jq4yp
December 3, 2025 at 1:00 PM
Case report: occlusion of the retinal vessels following intravitreal injection of aflibercept, 8.0 mg, in a woman with neovascular age-related macular degeneration. ja.ma/48jq4yp
Apixaban, paclitaxel, ibrutinib, and sildenafil use is associated with elevated rates of maculopathy, with incidence estimates up to 15.7% and dose-dependent risk for some agents.
ja.ma/4p0ylhF
ja.ma/4p0ylhF
December 2, 2025 at 1:00 PM
Apixaban, paclitaxel, ibrutinib, and sildenafil use is associated with elevated rates of maculopathy, with incidence estimates up to 15.7% and dose-dependent risk for some agents.
ja.ma/4p0ylhF
ja.ma/4p0ylhF
Pickleball-related ocular injuries in US emergency departments rose by an estimated 405 cases annually from 2021 through 2024, with most cases affecting adults aged 50 years or older.
ja.ma/4pytjJe
ja.ma/4pytjJe
December 1, 2025 at 1:00 PM
Pickleball-related ocular injuries in US emergency departments rose by an estimated 405 cases annually from 2021 through 2024, with most cases affecting adults aged 50 years or older.
ja.ma/4pytjJe
ja.ma/4pytjJe
Following Japanese regulatory approval of anti-VEGF therapy for #retinopathy of prematurity (ROP), there was a gradual decrease in the proportion of infants undergoing retinal photocoagulation.
ja.ma/4p2SoMF
ja.ma/4p2SoMF
November 30, 2025 at 1:00 PM
Following Japanese regulatory approval of anti-VEGF therapy for #retinopathy of prematurity (ROP), there was a gradual decrease in the proportion of infants undergoing retinal photocoagulation.
ja.ma/4p2SoMF
ja.ma/4p2SoMF
In this cohort study of repeat long-duration spaceflight missions, previous SANS diagnosis and optic disc edema severity reliably predicted recurrence in individual astronauts.
ja.ma/48kd4IE
ja.ma/48kd4IE
November 29, 2025 at 1:00 PM
In this cohort study of repeat long-duration spaceflight missions, previous SANS diagnosis and optic disc edema severity reliably predicted recurrence in individual astronauts.
ja.ma/48kd4IE
ja.ma/48kd4IE
On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity.
Register for the webinar: ja.ma/48oHolo
Register for the webinar: ja.ma/48oHolo
November 28, 2025 at 6:36 PM
On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity.
Register for the webinar: ja.ma/48oHolo
Register for the webinar: ja.ma/48oHolo
Descemet membrane endothelial keratoplasty (#DMEK) demonstrated superior contrast sensitivity compared with ultra-thin Descemet stripping automated endothelial keratoplasty (#DSAEK).
ja.ma/3MoVRX9
ja.ma/3MoVRX9
November 28, 2025 at 3:00 PM
Descemet membrane endothelial keratoplasty (#DMEK) demonstrated superior contrast sensitivity compared with ultra-thin Descemet stripping automated endothelial keratoplasty (#DSAEK).
ja.ma/3MoVRX9
ja.ma/3MoVRX9
The 23-item Vitreous Floaters Functional Questionnaire had high test-retest reliability and correlated with vitreous structure and visual function.
ja.ma/49GVIIn
ja.ma/49GVIIn
November 28, 2025 at 1:00 PM
The 23-item Vitreous Floaters Functional Questionnaire had high test-retest reliability and correlated with vitreous structure and visual function.
ja.ma/49GVIIn
ja.ma/49GVIIn
In patients with molecularly confirmed USH1C-associated retinopathy, longitudinal assessment demonstrates slow progression of vision loss and structural change into middle adulthood, with preservation of central vision in some cases.
ja.ma/3Mn83Ys
ja.ma/3Mn83Ys
November 27, 2025 at 3:00 PM
In patients with molecularly confirmed USH1C-associated retinopathy, longitudinal assessment demonstrates slow progression of vision loss and structural change into middle adulthood, with preservation of central vision in some cases.
ja.ma/3Mn83Ys
ja.ma/3Mn83Ys
Up to 82% of UK patients with geographic atrophy would accept intravitreal complement inhibitor therapy if it offered vision benefits, with perceived effectiveness and ability to attend clinic visits driving acceptability.
ja.ma/43V9hQS
ja.ma/43V9hQS
November 27, 2025 at 1:00 PM
Up to 82% of UK patients with geographic atrophy would accept intravitreal complement inhibitor therapy if it offered vision benefits, with perceived effectiveness and ability to attend clinic visits driving acceptability.
ja.ma/43V9hQS
ja.ma/43V9hQS
On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity.
Register for the webinar: ja.ma/4adNgAr
Register for the webinar: ja.ma/4adNgAr
November 26, 2025 at 5:00 PM
On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity.
Register for the webinar: ja.ma/4adNgAr
Register for the webinar: ja.ma/4adNgAr
In a small case series, topical compounded imiquimod 5% ointment was associated with complete or partial resolution of conjunctival MIS, OSSN, and PAM in five patients, with no serious safety events observed.
ja.ma/4pwroES
ja.ma/4pwroES
November 26, 2025 at 4:30 PM
In a small case series, topical compounded imiquimod 5% ointment was associated with complete or partial resolution of conjunctival MIS, OSSN, and PAM in five patients, with no serious safety events observed.
ja.ma/4pwroES
ja.ma/4pwroES
An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculature. Fundus photographs revealed perfluoro-n-octane bubbles in the inferior retina.
What would you do next?
ja.ma/4836CXO
What would you do next?
ja.ma/4836CXO
November 26, 2025 at 1:00 PM
An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculature. Fundus photographs revealed perfluoro-n-octane bubbles in the inferior retina.
What would you do next?
ja.ma/4836CXO
What would you do next?
ja.ma/4836CXO
Use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence. ja.ma/48jlJev
November 25, 2025 at 7:37 PM
Use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence. ja.ma/48jlJev
Among patients with newly diagnosed #glaucoma, lower wealth was associated with decreased odds of achieving the minimum reduction in intraocular pressure recommended by national guidelines on quality of care. ja.ma/4rglEAT
November 24, 2025 at 1:00 PM
Among patients with newly diagnosed #glaucoma, lower wealth was associated with decreased odds of achieving the minimum reduction in intraocular pressure recommended by national guidelines on quality of care. ja.ma/4rglEAT
The incidence of acute angle closure following pharmacologic pupillary dilation in a large teleretinal diabetic retinopathy screening program was low. ja.ma/4oYolFM
November 23, 2025 at 1:00 PM
The incidence of acute angle closure following pharmacologic pupillary dilation in a large teleretinal diabetic retinopathy screening program was low. ja.ma/4oYolFM
This case report describes the discovery of Stargardt disease in an individual 4 years after having been included as a healthy control in an adaptive optics imaging study. ja.ma/4o1xM5T
November 21, 2025 at 3:00 PM
This case report describes the discovery of Stargardt disease in an individual 4 years after having been included as a healthy control in an adaptive optics imaging study. ja.ma/4o1xM5T
In a cohort study of International Space Station crewmembers, early increases in total retinal thickness measured by optical coherence tomography (#OCT) at 30 days predicted progression of #OpticDiscEdema up to 6 months into spaceflight.
ja.ma/49pyo1J
ja.ma/49pyo1J
November 20, 2025 at 5:00 PM
In a cohort study of International Space Station crewmembers, early increases in total retinal thickness measured by optical coherence tomography (#OCT) at 30 days predicted progression of #OpticDiscEdema up to 6 months into spaceflight.
ja.ma/49pyo1J
ja.ma/49pyo1J
Among Singaporean older adults, the contemporary prevalence of undiagnosed age-related #MacularDegeneration and #DiabeticRetinopathy approached 90%, while undiagnosed #Cataracts and #Glaucoma affected about 40% and 48%, respectively.
ja.ma/4rf4Vhu
ja.ma/4rf4Vhu
November 20, 2025 at 4:30 PM
Among Singaporean older adults, the contemporary prevalence of undiagnosed age-related #MacularDegeneration and #DiabeticRetinopathy approached 90%, while undiagnosed #Cataracts and #Glaucoma affected about 40% and 48%, respectively.
ja.ma/4rf4Vhu
ja.ma/4rf4Vhu
This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood. ja.ma/49Y0DET
November 17, 2025 at 2:00 PM
This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood. ja.ma/49Y0DET
This case report documents vision outcomes in a 15-year-old boy following orbital cellulitis and subperiosteal abscess. ja.ma/3K5QY4B
November 16, 2025 at 2:00 PM
This case report documents vision outcomes in a 15-year-old boy following orbital cellulitis and subperiosteal abscess. ja.ma/3K5QY4B