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JAMA Psychiatry
@jamapsychiatry.com
JAMA Psychiatry is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

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Recent US #opioid overdose deaths have declined 41%, mainly due to a shrinking at-risk population and plateauing mortality rates. Continued surveillance is needed to predict and prevent harm.

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November 29, 2025 at 3:00 PM
On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity.

Register for the webinar: ja.ma/4pBrEm2
November 28, 2025 at 6:36 PM
Neuronal autophagy may bridge stress and psychiatric pathology; ongoing research explores its role in #depression, brain regions, biomarkers, and response to #antidepressants.

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November 28, 2025 at 4:00 PM
Paternal genetic risk for psychiatric and substance use disorders may predict offspring risk, with indirect genetic and rearing effects strongest for substance use conditions.

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November 27, 2025 at 4:00 PM
On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity.

Register for the webinar: ja.ma/3XOwS22
November 26, 2025 at 4:59 PM
Telemental health accounted for 27.8% of US adult outpatient mental health visits in 2021–2022, with higher use among younger adults, high-income, privately insured, urban residents, and those receiving psychotherapy.

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November 26, 2025 at 4:30 PM
From @jamaneurology.com: Among US veterans, obstructive sleep apnea was independently associated with an increased risk of developing #Parkinson disease, even after accounting for potential confounders and competing risks.

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November 24, 2025 at 6:30 PM
From @jamaneurology.com: More than half of the US population experienced health loss due to neurological, neurodevelopmental, metabolic, or infectious disorders in 2021, with #stroke and #dementia ranking among the top causes of disability and death.

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November 24, 2025 at 6:00 PM
"We therefore issue an urgent call to action: psychiatric associations and guideline committees should explicitly evaluate and consider #GLP-1RAs as a strategy to manage psychotropic-induced weight gain."

Learn more in this Viewpoint: ja.ma/3XQfV7e
November 24, 2025 at 12:00 PM
Higher polygenic risk scores for bipolar disorder were associated with favorable treatment outcomes after lithium augmentation in antidepressant non-responders with unipolar depression. ja.ma/4ict9EO
November 23, 2025 at 12:00 PM
Viewpoint: Suicide risk prediction should shift from static assessments to dynamic models that incorporate real-time data, enabling personalized interventions and actionable insights for prevention.

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November 22, 2025 at 12:00 PM
Individuals with schizophrenia exhibit region-specific reductions in dendritic spine densities across cortical regions involved in visual-spatial working memory. ja.ma/48dYiTW
November 21, 2025 at 12:00 PM
💬 Viewpoint: Generative #AI could transform mental health assessment by combining qualitative narratives with quantitative rigor; responsible development requires robust frameworks for validity, reliability, and fairness.

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November 20, 2025 at 3:00 PM
After the October 7, 2023, terrorist attacks in Israel, benzodiazepine prescriptions increased by 219% in the first week, primarily from primary care physicians. ja.ma/3JMyNRv
November 20, 2025 at 12:00 PM
Meta-analysis: Mental health apps for #depression or #anxiety are widely adopted (92%) but adherence is moderate (62%). Reminders and personalization boost engagement; attrition remains a key challenge. ja.ma/47LOqSk
November 19, 2025 at 4:30 PM
In this cohort study, young people with mental health problems meeting criteria for early clinical stages were at heightened risk of developing subsequent stages, independent of early life risk factors. ja.ma/49pONDs
November 18, 2025 at 12:00 PM
Individuals with #ADHD treated with stimulants have a nonnegligible risk of developing psychosis or bipolar disorder, with a higher risk associated with amphetamines compared to methylphenidate. ja.ma/49hysAD
November 17, 2025 at 12:00 PM
Despite a slight overall decline in psychiatric bed capacity between 2011 and 2023, the share of beds at freestanding psychiatric facilities owned by large for-profit chains increased. ja.ma/4nRKcgw
November 16, 2025 at 12:00 PM
Soft drink consumption is linked to an increased risk of major depressive disorder and greater depressive symptom severity, mediated by changes in gut microbiota, particularly Eggerthella abundance. ja.ma/4oDZmr3
November 15, 2025 at 12:00 PM
A Swedish register-based cohort study involving almost 3.5 million individuals followed from birth found that offspring exposed to parental mental disorders had an increased risk of mortality up to the age of 51 years. ja.ma/3WKsYH1
November 14, 2025 at 12:00 PM
Adults exposed to sexual assault were at higher risk of developing functional somatic disorders, including single-organ and multiorgan subtypes—over five years, finds this cohort study.

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November 12, 2025 at 4:15 PM
RCT: Daily oxytocin administration combined with positive physical intimacy was linked to improved wound healing and reduced cortisol; oxytocin alone or positive interactions without physical intimacy did not enhance healing.

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November 12, 2025 at 3:00 PM
A growing body of literature suggests that transgender and nonbinary individuals experience poorer mental health outcomes compared to cisgender people.

This review summarizes current evidence and identifies knowledge gaps in the existing literature. ja.ma/47OsnJx
November 11, 2025 at 12:00 PM
An automated treatment decision rule (TDR) can effectively assign older adults with late-life depression to psychotherapy or usual care, improving treatment outcomes and potentially increasing precision and cost-effectiveness. ja.ma/47KbZcQ
November 10, 2025 at 12:00 PM
RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective. ja.ma/4hRQmw6
November 9, 2025 at 12:00 PM