@jasonsims89.bsky.social
Italian - American scientist interested in DNA repair, repetitive DNA and Ribosome Heterogeneity. Microscopy and Imaging enthusiasts. Nanopore aficionado.
Reposted
🚨 New Science paper from the Gerlich lab!
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
December 4, 2025 at 7:18 PM
🚨 New Science paper from the Gerlich lab!
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
The team shows how cohesin helps broken DNA find the right template: by opening local DNA loops to shrink the search area and by keeping the damaged strand close to its sister copy: science.org/doi/10.1126/science.adw0566
Reposted
@science.org 🧬🔬 A vision of #chromosome organization | Science www.science.org/doi/10.1126/...
@vram142.bsky.social et al.
@vram142.bsky.social et al.
A vision of chromosome organization
Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure
www.science.org
December 5, 2025 at 5:24 AM
@science.org 🧬🔬 A vision of #chromosome organization | Science www.science.org/doi/10.1126/...
@vram142.bsky.social et al.
@vram142.bsky.social et al.
Reposted
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 5, 2025 at 7:46 AM
Excited to share our latest fully in-house paper! 🎉
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
We show how cohesin integrates loop extrusion with sister tethering to guide the homology search during DNA repair.
Huge congratulations to all authors, and to @fedeteloni.bsky.social for leading this work 👏
We’re excited to see his next steps!
Reposted
👏 Thomas Vogl, Center for #CancerResearch at #MedUniVienna, has been accepted into the Young Investigator Programme by @embo.org!
He is investigating how the gut microbiome and #immunesystem together influence the success of #cancertherapies. ⬇️
He is investigating how the gut microbiome and #immunesystem together influence the success of #cancertherapies. ⬇️
Thomas Vogl accepted into EMBO Young Investigator Programme
Read more about his research!
www.meduniwien.ac.at
December 5, 2025 at 8:59 AM
👏 Thomas Vogl, Center for #CancerResearch at #MedUniVienna, has been accepted into the Young Investigator Programme by @embo.org!
He is investigating how the gut microbiome and #immunesystem together influence the success of #cancertherapies. ⬇️
He is investigating how the gut microbiome and #immunesystem together influence the success of #cancertherapies. ⬇️
Reposted
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
December 5, 2025 at 9:47 AM
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Reposted
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA @science.org @albertomarin.bsky.social @gerlichlab.bsky.social @imbavienna.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
December 5, 2025 at 3:28 AM
Extrusive and cohesive cohesin cooperate to repair double-strand breaks in DNA @science.org @albertomarin.bsky.social @gerlichlab.bsky.social @imbavienna.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted
🧬 New strategy to fight #AML: A study led by @floriangrebien.bsky.social & team at Vetmeduni, @stanna-ccri.bsky.social & CeMM identified the protein SPOP as a direct regulator of the stability of NUP98 fusion oncoproteins, a potential target for new therapies.
➡️ bit.ly/3M2RfWz
📄 bit.ly/4omtZ3x
➡️ bit.ly/3M2RfWz
📄 bit.ly/4omtZ3x
November 28, 2025 at 7:31 AM
🧬 New strategy to fight #AML: A study led by @floriangrebien.bsky.social & team at Vetmeduni, @stanna-ccri.bsky.social & CeMM identified the protein SPOP as a direct regulator of the stability of NUP98 fusion oncoproteins, a potential target for new therapies.
➡️ bit.ly/3M2RfWz
📄 bit.ly/4omtZ3x
➡️ bit.ly/3M2RfWz
📄 bit.ly/4omtZ3x
Reposted
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
November 26, 2025 at 4:14 PM
New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD
Reposted
Magnus Nordborg from the Gregor Mendel Institute and Sasha Martens at the Max Perutz Labs Vienna were recently awarded Synergy Grants by the European Research Council (ERC)
@gmivienna.bsky.social @maxperutzlabs.ac.at
Read more about their projects: lnkd.in/d3w8y7ty
@gmivienna.bsky.social @maxperutzlabs.ac.at
Read more about their projects: lnkd.in/d3w8y7ty
November 28, 2025 at 7:43 AM
Magnus Nordborg from the Gregor Mendel Institute and Sasha Martens at the Max Perutz Labs Vienna were recently awarded Synergy Grants by the European Research Council (ERC)
@gmivienna.bsky.social @maxperutzlabs.ac.at
Read more about their projects: lnkd.in/d3w8y7ty
@gmivienna.bsky.social @maxperutzlabs.ac.at
Read more about their projects: lnkd.in/d3w8y7ty
Reposted
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
November 28, 2025 at 3:12 PM
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
Reposted
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 23, 2025 at 3:47 PM
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Reposted
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
November 21, 2025 at 8:20 AM
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
Reposted
We've teamed up with Axion BioSystems to bring you the Maestro Pro™ MEA system and neural media for both functional cultures and publication-ready data. 🤝
📍 Learn more at booth #1521! #SfN25
📍 Learn more at booth #1521! #SfN25
November 18, 2025 at 7:55 PM
We've teamed up with Axion BioSystems to bring you the Maestro Pro™ MEA system and neural media for both functional cultures and publication-ready data. 🤝
📍 Learn more at booth #1521! #SfN25
📍 Learn more at booth #1521! #SfN25
Reposted
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
November 15, 2025 at 8:26 PM
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
Reposted
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted
Multilingualism is associated with a reduced risk of accelerated ageing, according to data from more than 86,000 people across 27 European countries published in Nature Aging. go.nature.com/4hWRpLh #medsky 🧪
November 11, 2025 at 2:36 PM
Multilingualism is associated with a reduced risk of accelerated ageing, according to data from more than 86,000 people across 27 European countries published in Nature Aging. go.nature.com/4hWRpLh #medsky 🧪
Reposted
We are proud to see Peter Peneder, formerly with the Tomazou group, contributing to such an impressive project!
🗨️Chat with your cells, explore #CellWhisperer!
CeMM PI Christoph Bock (@bocklab.bsky.social) together with @meduniwien.ac.at & @stanna-ccri.bsky.social have developed a new #AI tool that lets scientists explore single-cell data using plain English.
➡️ https://bit.ly/3JQqe87
📄 https://bit.ly/3WJCxGi
CeMM PI Christoph Bock (@bocklab.bsky.social) together with @meduniwien.ac.at & @stanna-ccri.bsky.social have developed a new #AI tool that lets scientists explore single-cell data using plain English.
➡️ https://bit.ly/3JQqe87
📄 https://bit.ly/3WJCxGi
November 11, 2025 at 10:29 AM
We are proud to see Peter Peneder, formerly with the Tomazou group, contributing to such an impressive project!
Reposted
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Tenure-Track Professorship in Genome Biology - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12848567
Launch your lab at the Max Perutz Labs and join us in our mission to analyze and reconstitute complex biological systems across scales.
www.nature.com
November 4, 2025 at 2:43 PM
Another opportunity to join @maxperutzlabs.ac.at !
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it!
www.nature.com/naturecareer...
Reposted
Reposted
Check out our new paper @jci.org
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
JCI -
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org
October 17, 2025 at 6:31 PM
Check out our new paper @jci.org
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
High 4E-BP-1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing Sarcoma
www.jci.org/articles/vie...
We show that chr8 gains drive poor outcome in EwS via 4E-BP-1
@dkfz.bsky.social
@nct-heidelberg.bsky.social
@uniheidelberg.bsky.social
Reposted
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 2:08 PM
ISTA @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology, to develop tools for cryo-EM, cryo-ET, structural prediction methods and protein interaction analysis!
Please spread the word!
ista.ac.at/en/job/tenur...
Please spread the word!
ista.ac.at/en/job/tenur...