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Reposted by Jepson Lab, UCL

Marc Dionne @marcsdionne.bsky.social · Jun 3

My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

www.philanthropy.cam.ac.uk

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Reposted by Jepson Lab, UCL

Abigail Wilson, PhD @abigaildwilson.bsky.social · May 16

The Inaugural UCL Dystonia Day Symposium was held this week! An amazing line up of speakers, posters and panel discussion. It was fantastic (and important) to be joined by @dystoniauk.bsky.social. A big shout out to @jepsonlabucl.bsky.social for organising. We hope to make this a regular occurrence!

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Jepson Lab, UCL @jepsonlabucl.bsky.social · May 1

Today is the last chance to register for this exciting Symposium on dystonia mechanisms at UCL! Get your tickets via the link below 👍.

www.ucl.ac.uk/ion/events/2...

Inaugural UCL Dystonia Day symposium

The UCL Dystonia Day Symposium seeks to bring basic and clinical researchers together to address this critical question. The Symposium will showcase cutting-edge research from early career researchers...

www.ucl.ac.uk

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Reposted by Jepson Lab, UCL

British Neuroscience Association @britishneuro.bsky.social · Apr 29

🎉We are delighted to congratulate the winner of the 2025 BNA Credibility in Neuroscience Prize: Rob Wykes, @uniofmanchester.bsky.social @epilepsyinst.bsky.social

www.bna.org.uk/mediacentre/...

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Apr 28

Deadline for the UCL Dystonia Day Symposium is coming up this week! May 1st, 4pm! If you would like to join us to hear about cutting-edge research into dystonia patho-mechanisms, please visit the link below:

www.ucl.ac.uk/ion/events/2...

Inaugural UCL Dystonia Day symposium

The UCL Dystonia Day Symposium seeks to bring basic and clinical researchers together to address this critical question. The Symposium will showcase cutting-edge research from early career researchers...

www.ucl.ac.uk

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Apr 10

Very excited by the spectacular range of talks and posters we have planned for the UCL Dystonia Day Symposium on May 14th! Anyone in the neighbourhood who is interested in dystonia, please join us by registering through the link below:

www.ucl.ac.uk/ion/events/2...

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Reposted by Jepson Lab, UCL

Cahir O'Kane @cahirokane.bsky.social · Mar 31

Worth following @fly-broadcast.bsky.social for new fly papers on PubMed. They deserve a lot more than 50 followers!
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social

fly paper broadcast @fly-broadcast.bsky.social · Mar 31

PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth
#Drosophila

PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth #Drosophila

PubMed link

pubmed.ncbi.nlm.nih.gov

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Reposted by Jepson Lab, UCL

Alicia Hidalgo Lab @aliciahidalgolab.bsky.social · Mar 15

Last few days to apply!
Post-doctoral position 3 years Wellcome funded in UK
To investigate how experience shapes the brain
Drosophila neurogenetics, imaging, behaviour
Deadline 19/3/25
Pls RP.
#drosophila
#postdoc
#jobs
Apply here

edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

Research Fellow in Neurogenetics to investigate how experience shapes the brain - School of Biosciences - 98709 - Grade 7

A Research Fellow with experience in behavioural neurogenetics of Drosophila is sought. The aim of the project is to investigate how experience and behaviour shape the brain throughout life, the impac...

edzz.fa.em3.oraclecloud.com

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Reposted by Jepson Lab, UCL

Cahir O'Kane @cahirokane.bsky.social · Mar 4

Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.

We Are Recruiting Group Leaders - IBDM | Institut de Biologie du Développement de Marseille

The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in bio...

staging.ibdm.univ-amu.fr

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Mar 3

We are particularly interested in showcasing the work of early career researchers performing fundamental investigations into dystonia mechanisms and treatments. Check out the website above to register, and please send potential talk/poster abstracts to the organiser (😉).

Jepson Lab, UCL @jepsonlabucl.bsky.social · Mar 3

Just under two weeks to submit talk/poster abstracts for the inaugural UCL Dystonia Day Symposium!

www.ucl.ac.uk/ion/events/2....

Inaugural UCL Dystonia Day symposium

The UCL Dystonia Day Symposium seeks to bring basic and clinical researchers together to address this critical question. The Symposium will showcase cutting-edge research from early career researchers...

www.ucl.ac.uk

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Mar 3

Watch out for Abi's work soon, with more exciting investigations of #dystonia to come from her recent @wellcometrust.bsky.social Early Career Fellowship.

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Mar 3

Abi's talk highlighted work from the lab that she has led - as part of a great collaboration with the Brownstone and Kullmann groups at UCL - in identifying a new potential drug treatment for dystonia/dyskinesia using a Drosophila model 🪰.

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Mar 3

Really proud that @abigaildwilson.bsky.social was awarded the best talk prize at the Crick Rare Disease Conference today 👍.

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Feb 12

Please register on the website above and send abstracts for potential talks/posters to the contact lead. For the Symposium's talks, we are focusing on giving early career researchers an exciting opportunity to present their work. We look forward to seeing you there!

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Feb 12

We will also have an introductory talk from Victoria Wareham (Dystonia UK), a Panel discussion with established leaders on how to advance the field, and an exciting plenary talk from Prof. Manju Kurian (UCL Great Ormond Street Institute of Child Health).

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Feb 12

FYI: we will be hosting the inaugural UCL Dystonia Day, on May 14th!

This Symposium will showcase the latest research into defining dystonia patho-mechanisms and identifying novel treatments for this debilitating disease.

www.ucl.ac.uk/ion/events/2...

Inaugural UCL Dystonia Day symposium

www.ucl.ac.uk

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Reposted by Jepson Lab, UCL

Reza Maroofian @reza-maroofian.bsky.social · Jan 6

We report 35 patients with biallelic RBL2 loss-of-function variants presenting with developmental delay/intellectual disability, hypotonia, seizures, microcephaly & brain abnormalities. Drosophila models recapitulate key features & suggest RBL2 re-expression may help rescue neurological symptoms.

Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

Very happy to see our work with Henry Houlden's group and others on RBL2/Rbf mutations linked to a multifaceted neurodevelopmental disorder, published in Brain today. This work was led by super post-doc @gabrielaughey.bsky.social, Elisa Cali, and Reza Maroofian.

academic.oup.com/brain/advanc...

Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder

RBL2 dysfunction, which disrupts cell-cycle gene expression, has been linked to a severe neurodevelopmental disorder. Aughey et al. characterize a cohort o

academic.oup.com

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

What's a cell-cycle regulator doing in post-mitotic neurons?? Stay tuned - @gabrielaughey.bsky.social has exciting new data on this that we hope to present fully soon 🙂.

Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

Intriguingly, we identify a novel role for Rbf in mature neurons (after cell cycle exit), and show that Rbf knockdown in adult neurons is sufficient to disrupt movement in flies. Unexpected!

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

@gabrielaughey.bsky.social from @jepsonlabucl.bsky.social, and Elisa Cali provided supporting Drosophila studies, showing that mutants in the fly orthologue Rbf present with strikingly similar phenotypes to RBL2 patients, including developmental delay and movement/sleep defects.

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

RBL2/Rbf inhibit G>S transition during the cell cycle. Prior work has identified small numbers of patients with RBL2 mutations, leading to a neurodevelopmental disorder. This paper presents the largest cohort of RBL2 patients to date, revealing novel mutations and expanding the clinical spectrum.

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Dec 18

Very happy to see our work with Henry Houlden's group and others on RBL2/Rbf mutations linked to a multifaceted neurodevelopmental disorder, published in Brain today. This work was led by super post-doc @gabrielaughey.bsky.social, Elisa Cali, and Reza Maroofian.

academic.oup.com/brain/advanc...

Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder

RBL2 dysfunction, which disrupts cell-cycle gene expression, has been linked to a severe neurodevelopmental disorder. Aughey et al. characterize a cohort o

academic.oup.com

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Reposted by Jepson Lab, UCL

Moita Lab @moitalab.bsky.social · Dec 2

Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵

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Jepson Lab, UCL @jepsonlabucl.bsky.social · Nov 29

First post on BlueSky! Stellar post-doc from the lab @gabrielaughey.bsky.social will be giving a Development Node webinar next week 🙂, describing his work using Drosophila to probe cell-cycle dysregulation in neurodevelopmental disease. Please tune in!

thenode.biologists.com/development-...

Development presents... December webinar on gene regulation - the Node

Hear from two early-career researchers studying gene regulation.

thenode.biologists.com

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