Jon Brudvig
@jonbrudvig.bsky.social
Translating the Science of Health & Longevity
USD Bio Professor, Drug Developer
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USD Bio Professor, Drug Developer
📖 Longer content on LinkedIn:
linkedin.com/in/jon-brudvig-phd-9b1830134
📰Sign up for my monthly Substack newsletter, Translation:
jonbrudvig.substack.com
Observational and interventional studies tell us that microdoses in the range of 0.02–0.3 mg/day are protective. That’s thousands of times lower than psychiatric doses, with a nearly zero risk of toxicity or side effects, and very inexpensive.
This is easily achieved with lithium supplements. 🧪
This is easily achieved with lithium supplements. 🧪
August 21, 2025 at 6:05 PM
Observational and interventional studies tell us that microdoses in the range of 0.02–0.3 mg/day are protective. That’s thousands of times lower than psychiatric doses, with a nearly zero risk of toxicity or side effects, and very inexpensive.
This is easily achieved with lithium supplements. 🧪
This is easily achieved with lithium supplements. 🧪
🧠 Mechanisms: blocks tau phosphorylation, shifts amyloid processing, clears plaques. 🧪
August 21, 2025 at 6:05 PM
🧠 Mechanisms: blocks tau phosphorylation, shifts amyloid processing, clears plaques. 🧪
💊 Supplementing with 0.3 mg/day slows cognitive decline in Alzheimer's patients. 🧪
August 21, 2025 at 6:05 PM
💊 Supplementing with 0.3 mg/day slows cognitive decline in Alzheimer's patients. 🧪
🫗 Natural lithium in drinking water → 20%+ reduction in Alzheimer’s rates. 🧪
August 21, 2025 at 6:05 PM
🫗 Natural lithium in drinking water → 20%+ reduction in Alzheimer’s rates. 🧪
If you live to 95, your risk of developing dementia is 42%. For APOE4 carriers, it’s as high as 59%.
A trace mineral, lithium, can lower that risk at extremely low doses. So potently, that it could even counteract the impact of the worst genetic and environmental risk factors. 🧪
A trace mineral, lithium, can lower that risk at extremely low doses. So potently, that it could even counteract the impact of the worst genetic and environmental risk factors. 🧪
August 21, 2025 at 6:05 PM
If you live to 95, your risk of developing dementia is 42%. For APOE4 carriers, it’s as high as 59%.
A trace mineral, lithium, can lower that risk at extremely low doses. So potently, that it could even counteract the impact of the worst genetic and environmental risk factors. 🧪
A trace mineral, lithium, can lower that risk at extremely low doses. So potently, that it could even counteract the impact of the worst genetic and environmental risk factors. 🧪
Is it wise to use this drug off-label for longevity purposes? 🧪
My read of the current evidence is a qualified “yes.” In a healthy person that leans towards overnutrition moreso than undernutrition, metformin likely offers systemic benefits and protects against metabolic and inflammatory diseases.
My read of the current evidence is a qualified “yes.” In a healthy person that leans towards overnutrition moreso than undernutrition, metformin likely offers systemic benefits and protects against metabolic and inflammatory diseases.
August 13, 2025 at 4:49 PM
Is it wise to use this drug off-label for longevity purposes? 🧪
My read of the current evidence is a qualified “yes.” In a healthy person that leans towards overnutrition moreso than undernutrition, metformin likely offers systemic benefits and protects against metabolic and inflammatory diseases.
My read of the current evidence is a qualified “yes.” In a healthy person that leans towards overnutrition moreso than undernutrition, metformin likely offers systemic benefits and protects against metabolic and inflammatory diseases.
These hormones then exert a range of beneficial effects on target tissues, improving metabolism, increasing satiety, and decreasing inflammation in tissues throughout the body. This is quite similar to #GLP-1 injectables, but occurs in a more coordinated, integrated way. 🧪
August 13, 2025 at 4:49 PM
These hormones then exert a range of beneficial effects on target tissues, improving metabolism, increasing satiety, and decreasing inflammation in tissues throughout the body. This is quite similar to #GLP-1 injectables, but occurs in a more coordinated, integrated way. 🧪
What’s the rationale for and against metformin for #longevity?
First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪
First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪
August 13, 2025 at 4:49 PM
What’s the rationale for and against metformin for #longevity?
First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪
First, how does it work? As we’ve discussed in recent posts, metformin acts in the gut by binding a lysosomal protein called PEN2 and activating a response that increases production of incretin hormones like GLP-1, GIP, and PYY. 🧪
What can we, as scientists, healthcare professionals, and humans do about this?
We can care enough to spread the word. To educate the public on this very real health concern. To help people understand that this is not a fringe concern, pseudoscience, or internet hype.🧪
We can care enough to spread the word. To educate the public on this very real health concern. To help people understand that this is not a fringe concern, pseudoscience, or internet hype.🧪
August 6, 2025 at 5:44 PM
What can we, as scientists, healthcare professionals, and humans do about this?
We can care enough to spread the word. To educate the public on this very real health concern. To help people understand that this is not a fringe concern, pseudoscience, or internet hype.🧪
We can care enough to spread the word. To educate the public on this very real health concern. To help people understand that this is not a fringe concern, pseudoscience, or internet hype.🧪
And this is about to get much, much worse, as plastic production triples from current levels by 2060. 🧪
August 6, 2025 at 5:44 PM
And this is about to get much, much worse, as plastic production triples from current levels by 2060. 🧪
As plastic production and pollution has increased, levels of microplastics in our brains and bodies have increased in parallel. 🧪
(This figure from another recent paper, in sources at the end)
(This figure from another recent paper, in sources at the end)
August 6, 2025 at 5:44 PM
As plastic production and pollution has increased, levels of microplastics in our brains and bodies have increased in parallel. 🧪
(This figure from another recent paper, in sources at the end)
(This figure from another recent paper, in sources at the end)
This new report on the health implications from plastics pollution doesn’t mince words. Evidence is piling up that “plastics are a grave, growing, and under-recognised danger to human and planetary health.”🧪
August 6, 2025 at 5:44 PM
This new report on the health implications from plastics pollution doesn’t mince words. Evidence is piling up that “plastics are a grave, growing, and under-recognised danger to human and planetary health.”🧪
This week in the Lancet: “Plastics cause disease and death from infancy to old age and are responsible for health-related economic losses exceeding $1.5 trillion annually.”
🧪 A quick break down and call to action in this thread.
#Microplastics #Longevity
🧪 A quick break down and call to action in this thread.
#Microplastics #Longevity
August 6, 2025 at 5:44 PM
This week in the Lancet: “Plastics cause disease and death from infancy to old age and are responsible for health-related economic losses exceeding $1.5 trillion annually.”
🧪 A quick break down and call to action in this thread.
#Microplastics #Longevity
🧪 A quick break down and call to action in this thread.
#Microplastics #Longevity
In other words, metformin isn't just a glucose-lowering drug—it's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems. 🧪
July 29, 2025 at 1:57 PM
In other words, metformin isn't just a glucose-lowering drug—it's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems. 🧪
🧬 Study #2 (Diabetes, July 2025):
In high-fat-fed rats, met restored lipid sensing in the upper intestine, triggering release of the gut hormone GIP.
• A chronic high-fat diet blocks GIP secretion in response to feeding. Metformin relieves this blockage, restoring nutrient sensing and satiety. 🧪
In high-fat-fed rats, met restored lipid sensing in the upper intestine, triggering release of the gut hormone GIP.
• A chronic high-fat diet blocks GIP secretion in response to feeding. Metformin relieves this blockage, restoring nutrient sensing and satiety. 🧪
July 29, 2025 at 1:57 PM
🧬 Study #2 (Diabetes, July 2025):
In high-fat-fed rats, met restored lipid sensing in the upper intestine, triggering release of the gut hormone GIP.
• A chronic high-fat diet blocks GIP secretion in response to feeding. Metformin relieves this blockage, restoring nutrient sensing and satiety. 🧪
In high-fat-fed rats, met restored lipid sensing in the upper intestine, triggering release of the gut hormone GIP.
• A chronic high-fat diet blocks GIP secretion in response to feeding. Metformin relieves this blockage, restoring nutrient sensing and satiety. 🧪
🔬 Study #1 (Lancet eBioMedicine, July 2025):
Longitudinal plasma proteomics in ~100 humans before and after met revealed 23 consistently altered proteins.
Top hits are signatures of the enteroendocrine cells that produce GLP-1 and GIP, reinforcing that these are the key cellular targets. 🧪
Longitudinal plasma proteomics in ~100 humans before and after met revealed 23 consistently altered proteins.
Top hits are signatures of the enteroendocrine cells that produce GLP-1 and GIP, reinforcing that these are the key cellular targets. 🧪
July 29, 2025 at 1:57 PM
🔬 Study #1 (Lancet eBioMedicine, July 2025):
Longitudinal plasma proteomics in ~100 humans before and after met revealed 23 consistently altered proteins.
Top hits are signatures of the enteroendocrine cells that produce GLP-1 and GIP, reinforcing that these are the key cellular targets. 🧪
Longitudinal plasma proteomics in ~100 humans before and after met revealed 23 consistently altered proteins.
Top hits are signatures of the enteroendocrine cells that produce GLP-1 and GIP, reinforcing that these are the key cellular targets. 🧪
Metformin doesn’t just lower glucose; it teaches your gut how to sense nutrients again. Two new papers show exactly how this works, and why it matters. 💊🧪💊
Broken down in this thread.
#Longevity #Aging #Healthspan
Broken down in this thread.
#Longevity #Aging #Healthspan
July 29, 2025 at 1:57 PM
Metformin doesn’t just lower glucose; it teaches your gut how to sense nutrients again. Two new papers show exactly how this works, and why it matters. 💊🧪💊
Broken down in this thread.
#Longevity #Aging #Healthspan
Broken down in this thread.
#Longevity #Aging #Healthspan
Life is Shorter Than You Think. Don’t Miss Your Bonus Chapter.
My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question.
jonbrudvig.substack.com/p/life-is-sh...
#Longevity #Healthspan #Aging 🧪
My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question.
jonbrudvig.substack.com/p/life-is-sh...
#Longevity #Healthspan #Aging 🧪
July 16, 2025 at 2:18 PM
Life is Shorter Than You Think. Don’t Miss Your Bonus Chapter.
My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question.
jonbrudvig.substack.com/p/life-is-sh...
#Longevity #Healthspan #Aging 🧪
My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question.
jonbrudvig.substack.com/p/life-is-sh...
#Longevity #Healthspan #Aging 🧪
Psilocybin extends lifespan in mice. But this is bigger than just a new geroprotective drug; it suggests an entirely new drug target—and it probably isn't the one you think. 🧪🧠🧪
substack.com/profile/1091...
#longevity #psychedelics #psilocybin
substack.com/profile/1091...
#longevity #psychedelics #psilocybin
July 15, 2025 at 10:00 PM
Psilocybin extends lifespan in mice. But this is bigger than just a new geroprotective drug; it suggests an entirely new drug target—and it probably isn't the one you think. 🧪🧠🧪
substack.com/profile/1091...
#longevity #psychedelics #psilocybin
substack.com/profile/1091...
#longevity #psychedelics #psilocybin
Or maybe you’re three months into your new exercise program and want to assess the impact. If the test shows that you’ve decreased your brain age by three years, along with significant benefits across several other organ systems, that might be the inspiration you need to stay on track. 🧪
July 10, 2025 at 4:50 PM
Or maybe you’re three months into your new exercise program and want to assess the impact. If the test shows that you’ve decreased your brain age by three years, along with significant benefits across several other organ systems, that might be the inspiration you need to stay on track. 🧪
If your brain is aging faster than the rest of your body, it may be time to cut alcohol and commit to regular exercise. If your brain is aging slowly but your gut is aging quickly, cleaning up your diet might be the most important place to start (Yes, you should still exercise). 🧪
July 10, 2025 at 4:50 PM
If your brain is aging faster than the rest of your body, it may be time to cut alcohol and commit to regular exercise. If your brain is aging slowly but your gut is aging quickly, cleaning up your diet might be the most important place to start (Yes, you should still exercise). 🧪
New research from the Wyss-Coray group confirms this idea, showing that organs do indeed age at different rates in a cohort of 40,000+ people. Perhaps more importantly, accelerated organ aging is linked to increased disease risk and earlier mortality. 🧪
July 10, 2025 at 4:50 PM
New research from the Wyss-Coray group confirms this idea, showing that organs do indeed age at different rates in a cohort of 40,000+ people. Perhaps more importantly, accelerated organ aging is linked to increased disease risk and earlier mortality. 🧪
First, the scientific premise. Your organs don't all age at the same rate. This might seem intuitive—you’ve seen some people develop Alzheimer’s (brain disease) in old age, while others develop atrial fibrillation (heart disease) or kidney disease. 🧪
July 10, 2025 at 4:50 PM
First, the scientific premise. Your organs don't all age at the same rate. This might seem intuitive—you’ve seen some people develop Alzheimer’s (brain disease) in old age, while others develop atrial fibrillation (heart disease) or kidney disease. 🧪
What if a quick blood test could tell you how fast each of your organs are aging? 🧪🩸🧪
That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford.
Broken down in this thread.
#Longevity #Aging
That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford.
Broken down in this thread.
#Longevity #Aging
July 10, 2025 at 4:50 PM
What if a quick blood test could tell you how fast each of your organs are aging? 🧪🩸🧪
That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford.
Broken down in this thread.
#Longevity #Aging
That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford.
Broken down in this thread.
#Longevity #Aging
This changes the scale of the #microplastics crisis.
We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪
www.nature.com/articles/d41...
We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪
www.nature.com/articles/d41...
July 9, 2025 at 8:31 PM
This changes the scale of the #microplastics crisis.
We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪
www.nature.com/articles/d41...
We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪
www.nature.com/articles/d41...