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juruehle.bsky.social
Julia Rühle
@juruehle.bsky.social
55 followers 100 following 1 posts
PhD Candidate @CRG.eu with @larsplus.bsky.social | Single Cell Tech Dev & Functional Genomics
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juruehle.bsky.social
Julia Rühle @juruehle.bsky.social · May 9
🧬🔍How can enhancers achieve tissue-specific activity?
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
larsplus.bsky.social
Lars Velten @larsplus.bsky.social · May 8
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
www.cell.com
2 11
Reposted by Julia Rühle
dkfz.bsky.social
Deutsches Krebsforschungszentrum (DKFZ) @dkfz.bsky.social · May 21
Researchers from the @crg.eu, the @irbbarcelona.org, and the DKFZ have discovered that the reservoir of blood stem cells shrinks with #age. It becomes increasingly dominated by stem cells that produce pro-inflammatory immune cells.
t1p.de/kjf02 👇
How aging changes the blood system in humans and mice
The reservoir of blood stem cells shrinks with age. It becomes increasingly dominated by stem cells that produce immune cells associated with chronic inflammation. Almost all of the 60-year-olds studi...
t1p.de
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Reposted by Julia Rühle
larsplus.bsky.social
Lars Velten @larsplus.bsky.social · May 21
Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
🧵
Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...
doi.org
7 42 130
juruehle.bsky.social
Julia Rühle @juruehle.bsky.social · May 9
🧬🔍How can enhancers achieve tissue-specific activity?
We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement 🚦 and discover that negative synergies drive specificity in hematopoiesis 🩸. Shoutout to @Robert Frömel & @larsplus.bsky.social for leading this work 🦹🦸.
larsplus.bsky.social
Lars Velten @larsplus.bsky.social · May 8
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
www.cell.com
2 11
Reposted by Julia Rühle
scherermich.bsky.social
Michael Scherer @scherermich.bsky.social · Apr 22
Honored to be able to speak among such an amazing line-up of speakers. Check out the Single Cell Genomics Day 2025 if you want to learn more about DNA methylation based lineage tracing: satijalab.org/scgd25/
Single Cell Genomics Day
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satijalab.org
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