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Justin Perry - Perry Lab @justinperryphd.bsky.social · 3d

It does raise the question of why the thymus hate? There should be a campaign to stop the thymus hate!

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Justin Perry - Perry Lab @justinperryphd.bsky.social · 11d

I think my lab works on immunometabolism 🤔🤷‍♂️🤣

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Justin Perry - Perry Lab @justinperryphd.bsky.social · 19d

Yuval Levin: Have an Argument.
Disengagement—not disagreement—is the real failure of our politics.
www.thefp.com/p/yuval-levi...

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Justin Perry - Perry Lab @justinperryphd.bsky.social · 28d

If you can't say that political violence, especially murdering someone in cold blood because you disagree with them, is not only morally wrong but anathema to a free country, then I would encourage you to immediately log off and take time for self-reflection.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Sep 9

Cool! Have you built in a way to integrate published phenotypes?

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Sep 8

I was interviewed by Nick Jahomes on the Mind & Matter podcast about our study in @nature.com. Nick does a great job asking questions & explaining nitty gritty. Please take time to listen to the episode & if you like it, consider supporting Nick's efforts. mindandmatter.substack.com/p/fructose-m...

Fructose, Microglia, Anxiety & Brain Development | Justin Perry | 249

Cellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.

open.substack.com

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Sep 5

Here's what I assume the study is in re: acetaminophen. It's a statistical analysis of a few dozen studies, to be clear, where the majority (especially the high quality ones) show a positive association. Reputable investigators. ehjournal.biomedcentral.com/articles/10....

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - Environmental Health

Background Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed...

ehjournal.biomedcentral.com

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Aug 29

What's the concern? They awarded it this most recent cycle. www.research.gov/grfp/Login.do

Federal government banner | Federal website standards

The federal government banner identifies official federal government sites. Learn how to implement the banner on your federal government site.

www.research.gov

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Aug 7

@wcm-imp.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Aug 7

Congratulations to Ana @anaccodo.bsky.social in my lab and the other awardees. It is a really great acknowledgement of excellent trainees doing cool science.

HHMI @hhmi.org · Aug 7

Congratulations 2025 Gilliam Fellows and Advisors! 🎉

The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.
Through this program, HHMI supports both graduate students and their faculty thesis advisors.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jul 28

Makes me miss the talented people back home in AK. Was just back at Forest Fair, another reminder of how great it is there.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jul 26

It's official. I'm happy to announce that I have been promoted to Associate Member @mskcancercenter.bsky.social. It is sincere when I say that this would not have been possible w/o the incredible work of the members of my lab. In fact, exciting news about them coming soon. Stay tuned.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jul 4

Today we remember our founding & the principles that this great nation was built on, that although we do not always live up to its ideals, it is those ideals, especially the liberty that pluralism affords, that will remain a beacon of hope for a more perfect union. As Madison wrote in Federalist 10:

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jul 2

Interesting. Congrats.

Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 18

New from @masslab.bsky.social @unibonn.bsky.social @immunosens.bsky.social out @natureportfolio.nature.com also shows maternal diet affects offspring macrophage function & disease susceptibility.

Mass Lab study: www.nature.com/articles/s41...
Our study: rdcu.be/eqx2G

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

www.nature.com

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

Update: Free-ish link: rdcu.be/eqx2G

Early life high fructose impairs microglial phagocytosis and neurodevelopment

Nature - Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in...

rdcu.be

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

3) A bit hidden in the supplement, but we propose a mostly-observational, not at all proven, mechanism of action in which HK2 localization is responsible for the defect in phagocytosis and altered metabolism. Very excited to work on this and the role of GLUT5/fructose in aging!

Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

2) Quantitation of fructose in the brain and important clarification that our effect did not seem to be due to circulating- or CNS-derived glucose (polyol pathway) or circulating lactate.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

What was new in the revision? A few things:
1) We created SLC2A5 (GLUT5) floxed mice to delete the transporter from myeloid cells during embryogenesis. This completely reversed the phagocytosis, metabolism, and behavioral phenotypes due to high fructose exposure.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

@mskcancercenter.bsky.social has a nice writeup on it here: www.mskcc.org/news/high-fr...
And we have a preprint here: pubmed.ncbi.nlm.nih.gov/37645894/ with an explainer here x.com/JustinPerryP...

High-Fructose Diet Harms Neurodevelopment and Leads to Anxiety in Mice, MSK Study Finds

A new laboratory study from MSK is shedding light on the mechanisms by which high fructose consumption early in life may directly impact brain development and increase the risk of anxiety disorders la...

www.mskcc.org

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 11

Out today from The Perry Lab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In @natureportfolio.nature.com www.nature.com/articles/s41... @mskcancercenter.bsky.social @weillcornell.bsky.social.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 3

Cool story. Wonder what this means when considering our finding that microglia (numbers defined by conventional protein markers, anyway) were surprisingly unaffected. rdcu.be/eoaRm

What are these other factors? 🤔

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity

Nature Communications - Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage...

rdcu.be

Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 2

Naturally, lots of questions remaining, including about how WNK1 is actually functioning to inform macrophage lineage commitment. Nevertheless, excited to see this story out. It's one of the best I have ever been a part of. @edinuni-irr.bsky.social writeup is here: edin.ac/3FtYS5B

Cell ‘drinking’ and enzyme activation shape immune cell fate

New study shows that a specific growth factor causes early-stage immune cells (macrophage precursors) to ‘drink’, which activates a special enzyme. This cell drinking and enzyme activation determines ...

edin.ac

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 2

5. Alissa then performed a whole bunch of experiments to demonstrate that WNK1 acts downstream of CSF1R (M-CSF receptor) to inform macrophage differentiation.

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Justin Perry - Perry Lab @justinperryphd.bsky.social · Jun 2

4. M-CSF-stimulated macropinocytosis is required for differentiation of myeloid progenitors into macrophages🤯.

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