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Reposted by Klaus Okkenhaug

Roychoudhuri Lab @roychoudhurilab.bsky.social · 3d

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

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Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 3d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Klaus Okkenhaug @klausokken.bsky.social · 4d

Nobel prize for Tregs!
www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Klaus Okkenhaug @klausokken.bsky.social · 7d

Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).

Kristoffer H Johansen presenting a talk at the Dept of Pathology, University of Cambridge.

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Klaus Okkenhaug @klausokken.bsky.social · Jul 29

Listen to James Edgar @campathology.bsky.social discuss cosmetic use of exosomes on BBC Radio 4 Inside Health: www.bbc.co.uk/sounds/play/...
(Spoiler alert: he does not approve).

Inside Health - Exosomes: Is cosmetics' biggest trend a health risk? - BBC Sounds

James finds out why there are fears over new skincare products, plus physio goes digital.

www.bbc.co.uk

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Klaus Okkenhaug @klausokken.bsky.social · Jul 28

Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...

De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells

The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...

www.science.org

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Reposted by Klaus Okkenhaug

Jie Yang @jieyang437.bsky.social · Jul 18

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis.

Deadline: 11 August 2025
my.corehr.com/pls/uoxrecru...

Lab info: www.oncology.ox.ac.uk/team/jie-yang

Job Details

my.corehr.com

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Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · Jun 17

I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰

European Research Council (ERC) @erc.europa.eu · Jun 17

📣 Good news: 281 top researchers have just won ERC Advanced Grants!

The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.

Find out more 👉 europa.eu/!JYKxkD

#ERCAdG #FrontierResearch @ec.europa.eu

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Reposted by Klaus Okkenhaug

Simon Cook @drsimoncook.bsky.social · Apr 8

I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...

Dr Len Stephens awarded the Morton Lecture | Babraham Institute

www.babraham.ac.uk

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Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · Mar 18

New research article from the lab led by the amazing @amydashwood.bsky.social !

In collaboration with @vib-switch-lab.bsky.social @cbdresearch.bsky.social we engineered variants of #IL2 designed for therapeutic use. 1/11

www.sciencedirect.com/science/arti...

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity

The pleotropic nature of interleukin-2 (IL2) has allowed it to be used as both a pro-inflammatory and anti-inflammatory therapeutic agent, through pro…

www.sciencedirect.com

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Reposted by Klaus Okkenhaug

Brian Ferguson @viropractor.bsky.social · Mar 7

Last few days to apply for this:

Brian Ferguson @viropractor.bsky.social · Feb 11

There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/

Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge

Research Assistant / Research Associate (Fixed Term) in the Department of Pathology at the University of Cambridge.

www.jobs.cam.ac.uk

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Klaus Okkenhaug @klausokken.bsky.social · Mar 5

Listen to Rahul talk about the study about 20 min into this programme: www.bbc.co.uk/sounds/play/...

PM - 05/03/2025 - BBC Sounds

Afternoon news and current affairs programme

www.bbc.co.uk

Reposted by Klaus Okkenhaug

Roychoudhuri Lab @roychoudhurilab.bsky.social · Mar 5

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

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Klaus Okkenhaug @klausokken.bsky.social · Mar 5

Excellent article by James Gallagher at the BBC summarising the study and its implications:
"Scientists crack how aspirin might stop cancers from spreading"
www.bbc.co.uk/news/article...

Aspirin: Scientists crack how painkiller might stop cancers from spreading

The cheap painkiller seems to help the immune system detect and destroy cancers.

www.bbc.co.uk

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Klaus Okkenhaug @klausokken.bsky.social · Mar 5

Brilliant new paper from Jie Yang @jieyang437.bsky.social and Rahul Roychoudhuri @roychoudhurilab.bsky.social linking aspirin to immune-mediated prevention of cancer metastasis.
www.nature.com/articles/s41...

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

www.nature.com

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Reposted by Klaus Okkenhaug

Babraham Institute @babrahaminst.bsky.social · Feb 12

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪

Latest Institute research with special guests ⤵️

www.eventbrite.co.uk/e/cellular-s...

Cellular signals for health & disease

A symposium marking the contributions of Len Stephens and Phillip Hawkins

www.eventbrite.co.uk

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Klaus Okkenhaug @klausokken.bsky.social · Feb 9

Seems dystopian, but this is now reality. Promoting diversity, equality and inclusiveness has become a crime and they are threatened to report anyone engaged in such activities. Free speech no longer applies.

Klaus Okkenhaug @klausokken.bsky.social · Jan 26

Welcome!

Reposted by Klaus Okkenhaug

School of Biological Sciences @cambridgebiosci.bsky.social · Jan 9

📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community!

Find out more about the position and apply: https://buff.ly/40m1udb

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Klaus Okkenhaug @klausokken.bsky.social · Jan 7

www.path.cam.ac.uk/news/profess...

Professor Ashley Moffett awarded Companion of the Order of St Michael and St George | Department of Pathology

We are delighted to announce that Professor Ashley Moffett has been awarded Companion of the Order of St Michael and St George in the King's New Year's Honours.

www.path.cam.ac.uk

Klaus Okkenhaug @klausokken.bsky.social · Jan 7

Many congratulations to Prof Ashley Moffett on this honour!
This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.

Pathology at Cambridge @campathology.bsky.social · Jan 7

Our very own Professor Ashley Moffett of Reproductive Immunology was awarded the prestigious CMP for Women’s Reproductive Health. The foremost international authority on the immunology of human reproduction, her work has helped explain high rates of pre-eclampsia and maternal mortality in Africa.

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Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · Dec 13

A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/

Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge

Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.

www.jobs.cam.ac.uk

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Klaus Okkenhaug @klausokken.bsky.social · Dec 12

I've added a PI3K starter pack.
Please help me populate it by replying to this post.
#PI3K #PTEN #AKT #mTOR #FOXO
go.bsky.app/7p2g5eN

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Reposted by Klaus Okkenhaug

ImmunoSketch @immunosketch.bsky.social · Dec 4

A starter pack for PhD students and Postdocs in Immunology to connect 🔽

Drop a 🧬 and I'll add you to the list.
Let's build the upcoming immuno community!

#ImmunoSky 🧪

go.bsky.app/RABVXY4

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Klaus Okkenhaug @klausokken.bsky.social · Dec 3

Really great talk!

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