Krzisch Lab
@krzischlab.bsky.social
Our research focuses on neurological disease modeling using human pluripotent stem cells, with a focus on glial cells.
To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.
March 17, 2025 at 10:27 AM
To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.
We found that human microglia that carry a mutation involved in familial Parkinson's disease get more reactive than control when stimulated with an inflammatory component. This suggests that they could worsen neuronal death.
March 17, 2025 at 10:27 AM
We found that human microglia that carry a mutation involved in familial Parkinson's disease get more reactive than control when stimulated with an inflammatory component. This suggests that they could worsen neuronal death.
To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.
March 17, 2025 at 10:26 AM
To discover this, we used human microglia transplanted into the brain of mice. This helps us create microglia that behave more like those in the human brain compared to lab-grown ones.
Microglia are the brain immune cells. In stress or disease conditions, they can get reactive, and this can potentially make them damage neurons.
March 17, 2025 at 10:09 AM
Microglia are the brain immune cells. In stress or disease conditions, they can get reactive, and this can potentially make them damage neurons.