Waggoner Lab
@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)
November 29, 2025 at 2:06 AM
One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)
Linked to throttling of B cell development at key checkpoints in bone marrow
November 29, 2025 at 2:06 AM
Linked to throttling of B cell development at key checkpoints in bone marrow
Hypergammaglobulinemia and exaggerated IgG2b from MZ compartment associated with B-cell extrinsic lymphopenia limited to Vav1-Cre model
November 29, 2025 at 2:06 AM
Hypergammaglobulinemia and exaggerated IgG2b from MZ compartment associated with B-cell extrinsic lymphopenia limited to Vav1-Cre model
Males still develop B cells in absence of Ddx3x but skewed towards MZ
November 29, 2025 at 2:06 AM
Males still develop B cells in absence of Ddx3x but skewed towards MZ