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Laura Torrens

@lauratorrens.bsky.social

34 followers 32 following 8 posts

Postdoctoral researcher in cancer genomics at IARC-WHO | Previously IDIBAPS and Icahn School of Medicine at Mount Sinai

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Laura Torrens @lauratorrens.bsky.social · Mar 31

Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer

Nature Genetics - Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution...

rdcu.be

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Reposted by Laura Torrens

Wellcome Sanger Institute @sangerinstitute.bsky.social · Apr 1

The #CancerGrandChallenges Mutographs team reveals how tobacco smoke damages DNA to drive different types of head and neck cancer 🧬

They also show that smoking combined with drinking alcohol can more than double the damaging effect on DNA ⤵️

www.sanger.ac.uk/news_item/sc...

Scientists unlock secret behind how smoking and drinking alcohol causes cancer

Scientists have revealed exactly how tobacco smoke damages DNA to drive the development of different types of head and neck cancer, a finding that could unlock new treatments and prevention strategies...

www.sanger.ac.uk

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Laura Torrens @lauratorrens.bsky.social · Mar 31

7/ Last but not least, a huge thanks to our fantastic team & collaborators from IARC-WHO, @sangerinstitute.bsky.social, @ucsandiego.bsky.social
and many more who made this work possible! 💡🔬 Also to @cancergrand.bsky.social for fantastic support, as well as to the patients and their families ♥️

Laura Torrens @lauratorrens.bsky.social · Mar 31

6/ These findings deepen our understanding of how tobacco & alcohol contribute to HNC, reinforcing the urgent need for prevention efforts to reduce these exposures globally. 🚭

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Laura Torrens @lauratorrens.bsky.social · Mar 31

5/ And there’s more: cases exposed to both tobacco & alcohol had more alcohol-related mutations than alcohol-only cases, suggesting a combined effect. 🍷➕🚬🟰🙅‍♀️

Laura Torrens @lauratorrens.bsky.social · Mar 31

4/ We also found that tobacco-induced mutations vary by anatomical site in the head & neck, suggesting that tissue-specific factors modulate mutagenesis.

Laura Torrens @lauratorrens.bsky.social · Mar 31

3/ Our findings confirm tobacco as the main mutagen in HNC, but with a twist: we identified six distinct tobacco-related mutational signatures, which could be caused by different carcinogens in cigarette smoke. 🚬

Laura Torrens @lauratorrens.bsky.social · Mar 31

2/ To tackle this, we analyzed whole-genome data from 265 HNC cases across 8 countries in Europe & South America—offering an unprecedented geographical representation of cases.

Laura Torrens @lauratorrens.bsky.social · Mar 31

1/ At least 1 in 2 cancers is linked to modifiable risk factors. Identifying these exposures and understanding their effects is key to prevention, but challenging due to global differences in lifestyles & environments. 🌍

Laura Torrens @lauratorrens.bsky.social · Mar 31

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer

Nature Genetics - Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution...

rdcu.be

1 6 9