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laurenbird.bsky.social
Lauren Bird
@laurenbird.bsky.social
67 followers 120 following 3 posts
Postdoc, Lamason lab @ MIT Biology. Interested in intracellular pathogens 🧫👩🏻‍🔬 (she/her)
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Reposted by Lauren Bird
plosbiology.org
PLOS Biology @plosbiology.org · Jul 25
#Legionella pumps 100s of effector proteins into host cells, including to #mitochondria. @drdstojanovski.bsky.social &co show that effector LpPIP is a tail-anchored protein of the MOM that recruits protein phosphatase 1 to modulate the host mitochondrial P-proteome @plosbiology.org 🧪 plos.io/4f2T5kE
Top: HeLa cells expressing FLAGLpPIP, or FLAGRVxFdead were stained with 100 nM MitoTracker Deep Red FM (mitochondria; MTDR) and, following fixation, processed for immunofluorescence using antibodies against FLAG (green) and PPP1CB (magenta). Nuclei were stained with Hoechst 33258 (blue). Scale bar represents 10 μm. Fluorescence signal profiles of FLAG and PPP1CB were measured across the indicated line of interest. Bottom: AlphaFold3 structure of LpPIP-PPP1CB complex labeled with the active site (purple) and three substrate binding grooves (yellow) of PPP1CB.
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laurenbird.bsky.social
Lauren Bird @laurenbird.bsky.social · Jul 2
Congrats Thomas and team!
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Lauren Bird @laurenbird.bsky.social · Apr 25
We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner.

A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
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laurenbird.bsky.social
Lauren Bird @laurenbird.bsky.social · Apr 25
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.

www.nature.com/articles/s41...
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
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