Liz Worthey
@lizworthey.bsky.social
3K followers 430 following 650 posts
#AssociateProf #CompBio #Omics #WomenInScience #LGBTQ+Ally #Scottish #PrecisionMedicine #HealthCare #MDx #ME/CFS #RareDisease #Informatics #SciFiNerd #LongCovidAffected sites.uab.edu/cgds/ she/her
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lizworthey.bsky.social
Thought I'd collect names for an ME/CFS Starter Pack: patients, advocates, researchers. For #diagnostics and #treatment for #ME/CFS, #LongCOVID, #Fibromyalgia, #POTS, and other related multisystem diseases. Send me a note to include.
Reposted by Liz Worthey
davidcorn.bsky.social
This ought to be engraved somewhere.
Reposted by Liz Worthey
iwillnotbesilenced.bsky.social
An unarmed veteran was attacked from behind, sustaining injuries and being dragged into a Portland ice building.
lizworthey.bsky.social
I think I can perhaps get access. Will talk to the PI.
lizworthey.bsky.social
My work email is [email protected]. Send me a note and we can chat.
lizworthey.bsky.social
My work email is [email protected]. Send me a note and we can chat.
lizworthey.bsky.social
My work email is [email protected]. Send me a note and we can chat.
lizworthey.bsky.social
Yes they would be. My work email is [email protected]. Send me a note and we can chat.
lizworthey.bsky.social
We have some bandwidth and so I’m interested in expanding the nbr of ME/CFS patients whose genomes we analyze. If you have data and would be interested in signing up to our protocol (we have found interesting findings in some, but not all people) please reach out and I can explain. #ME/CFS #Genomics
Reposted by Liz Worthey
agnescaruso.bsky.social
What types of variants are most commonly missed? #eshg2025
lizworthey.bsky.social
Was not discussed in that context. Sorry! Sounds like lots of work in this context, so maybe someone to look up.?
lizworthey.bsky.social
AM: 1,715 combinations with nominally significant impacts were identified in UK Biobank study. Two clinically relevant examples of effect heterogeneity were seen: 1) BMA -T2D attenuates with age, 2) LDL cholesterol exacerbates with increased urate. Study just published #ESHG2025
lizworthey.bsky.social
AM: Resid-Strat, DR by G, DR by X, and Raw-Strat methods were all tested in term of impact on Type 1 error. Each method was found to be differentially affected by collider biases #ESHG2025
lizworthey.bsky.social
AM: discussing sources of collider bias - biases that occur when an exposure and outcome (or factors causing these) each influence a common third variable #ESHG2025
lizworthey.bsky.social
AM: Asking: In precision medicine in patients with cardiovascular disease - how can we systematically identify patients differentially effected by a broad range of clinical variables and risk modifiers #ESHG2025
lizworthey.bsky.social
Up now Alice Man discussing Identification of effect modifiers using a stratified mendelian randomization algorithmic framework #ESHG2025
lizworthey.bsky.social
CA: Collectively these measurements account for 70% of variation, allowing generation of an accurate time of day prediction that acts as a proxy for internal circadian time #ESHG2025
lizworthey.bsky.social
CA: Noted that effects were associated with multiple psychiatric disorders #ESHG2025
lizworthey.bsky.social
CA: Oscillation measure developed seen to be highly correlated with sleep questionnaire data and propensity to work night shifts due to sleep cycle shift #ESHG2025
lizworthey.bsky.social
CA: Proteomics explains 68% of circadian effect (despite being a smaller dataset), NMR 39%, Biochemistry 13%, and cell counts 6% #ESHG2025
lizworthey.bsky.social
CA: Studying which tissues show greatest circadian effect - variability with amplitude >0.2 and R2> 0.01 #ESHG2025
lizworthey.bsky.social
CA: Variety of plasma omics available for analysis. Time of day effect seen across all these datasets; to variable degrees when pre-regressed with age, PCs, fasting, and other technical covariates #ESHG2025
lizworthey.bsky.social
CA: Studied in the UK Biobank; identification of variance to be used to predict dysregulation/disease risk #ESHG2025