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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group

@ljrusselllab.bsky.social

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Russell Lab | NUCancer | Newcastle University https://www.ncl.ac.uk/medical-sciences/people/profile/lisarussell.html

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · May 22

Lisa Russell just wrote an insightful article for #CancerNews from @cancerresearchuk.org where she takes us through the promise of super-enhancer biology and what it means for cancer. Read the whole article here:
news.cancerresearchuk.org/2025/05/21/b...

Beyond the genome: Harnessing the power of super-enhancers for blood cancer - Cancer Research UK - Cancer News

The mysteries of the epiregulome need to be tackled head-on if we are to get new precision treatments for blood cancers

news.cancerresearchuk.org

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 9d

Together with @avmoorman.bsky.social, we will lead the two research projects that will explore the biology of ALL and how we can use that information to find the most effective treatments and reduce the challenging long-term side effects of chemotherapy.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 9d

Two research projects at Newcastle University are celebrating £4.1million of investment from Cancer Research UK to explore how children with ALL, the same cancer Dan had, can be diagnosed and treated more effectively to improve survival rates.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 9d

We’re proud to share the inspiring story of Dr. Dan Mattison — diagnosed with leukaemia at age 14, and now a Foundation Year 2 doctor. Dan and his family are welcoming a £4.1 million investment from @cancerresearchuk.org. Read more here: www.ncl.ac.uk/press/articl...

Alumnus who survived teenage cancer welcomes multi-million funding

A Newcastle University graduate who survived cancer as a teen and was inspired to become a doctor by those who cared for him, is welcoming a multi-million pound investment from Cancer Research UK.

www.ncl.ac.uk

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 11d

Last week on #WorldCancerResearchDay the whole lab and other colleagues from @nucancer.bsky.social turned into bakers to help fundraising for @cancerresearchuk.org, a charity close to us for their commitment to fund groundbreaking projects in cancer research. Lovely seeing the public engaged!

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 19d

September is #ChildhoodCancerAwarenessMonth. Our team joined the @childcancernth.bsky.social campaign #PaintTheToonGold to show support for children with cancer and their families. Together, we can raise awareness and keep pushing research forward.

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 26d

We were excited to share our recent research findings and projects at #CLRUK25 in York. Dr. Brittain and Dr. Alqahtani were thrilled to present their projects, supported by @cancerresearchuk.org and @bloodcanceruk.bsky.social. Dr. Marchetti brought great energy while chairing the first session.

@letimarchetti.bsky.social and Frederik van Delft are chairing the first session at CLRUK25

Dr. Nicholas Brittain is presenting his CR_UK funded project titled (Mechanistic investigation of super-enhancer dynamics in B-ALL)

@dr-ahlamq.bsky.social is presenting her BloodCancer_UK funded project titled (Investigating the consequences of CEBP dysregulation in acute lymphoblastic leukaemia)

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 28d

Morning coffee and train for the whole lab today, direction #CLRUK25 in York! Looking forward to seeing everyone from the CLR-UK network! #ChildhoodCancerAwarenessMonth #BloodCancerAwarenessMonth

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Sep 4

Research is not a solo effort.
It takes teamwork. It takes belief. It takes collaboration.
We know what it takes to beat blood cancer and so does @dr-ahlamq.bsky.social whose work is funded by @bloodcanceruk.bsky.social grant co-led by Lisa & @letimarchetti.bsky.social
#BloodCancerAwarenessMonth

Lisa is the Principal Investigator of the group
but she still enjoys spending time in the lab to drive
the work to beat blood cancer.

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 8

Dr Brittain says "I am really excited to have joined
the @ljrusselllab.bsky.social group within @nucancer.bsky.social. I look
forward to applying the variety of cutting-edge
epigenomic techniques used within the group as we
continue to deepen our understanding of super-
enhancer biology"

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 8

We recently welcomed Dr Nicholas Brittain to the
LEGEND group, who has joined as a Research
Associate to investigate mechanisms driving
super-enhancers in paediatric leukaemia as part
of a research project funded by @cancerresearchuk.org

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 8

Recent nice weather called for a social outing of the LEGEND group, filled with fun, sport and a MUST stop for ice cream by the coast 🍦. We also had our first lab retreat at Cockle Park, featuring good scientific discussion 🧬 and a
visit by our @ukri.org MRC collaborators from Edinburgh ✨

Deserved rest after an exciting volleyball tournament

Ice-cream is the best way to end a great social outing with the lab

The group got bigger! We count, from the left: Camille (Research Technician), Ahmed (PhD student), Leti (PostDoc), Lisa (Group Leader), Ahlam (PostDoc), Nick (PostDoc) and Phoebe (PhD student)

MRC collaborators from Edinburgh, Chris A.Brackley (left) and Rodrigo Rivas Barbosa (right)

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 7

It even made the News and Views section on the Nature website which provides a lovely overview of the paper. [https://nature.com/articles/d41586-025-02421-0].

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 7

Read it 👉[https://rdcu.be/ezAx6]
Supported by @littleprincesses.bsky.social @bloodcanceruk.bsky.social and VIVO Biobank.

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Aug 7

Thrilled to have contributed to ground-breaking research led by Dr Joan Boyes (@universityofleeds.bsky.social‬), just out in Nature (‪@nature.com‬)! 🧬 We show that tiny DNA fragments, naturally cut from the genome, can linger—causing more damage & helping leukaemia progress.

Dr Zeqian Gao, Dr Joan Boyes, and Dylan Casey (PhD student) in the lab

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Jul 8

Our lab was delighted to host a visit from @cancerresearchuk.org fundraisers, campaigners, and patient advocates Sue Duncombe and Patrick McGuire. It was a pleasure to share our research, to give an insight into our daily work and highlight how CRUK support helps us move science forward.

Camille is showing how the transfected cell lines appear under a florescent microscope

Ahmed and Nick are explaining how we visualize genome editing using gel electrophoresis

Ahmed and Nick are explaining the technical aspect of using gel electrophoresis

Leti is explaining how we use blood cancer cell lines to explore options for better therapy interventions

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Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group

Children's Cancer North @childcancernth.bsky.social · Apr 28

🌟 Nominate Children’s Cancer North for a chance to win £5,000!

The Benefact Movement for Good Health & Wellbeing Special Draw is open until May 4. By nominating us, Children’s Cancer North could win £5,000 to help make life better for children and young people affected by cancer

👉 loom.ly/dFhKtac

Nominate a charity - Movement for Good

Nominate a charity for a Movement for Good award now.

loom.ly

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Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group

Anthony Moorman @avmoorman.bsky.social · Jun 27

We are hiring! Great opportunity for a RA with bioinformatic skills

We are looking for talented researcher to work on a project to detect gene fusions and driver mutations in a large cohort of children with ALL treated across multiple different trials to determine their clinical relevance.

Research Assistant/Associate in Cancer Genomics

jobs.ncl.ac.uk

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Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group

Letizia Marchetti @letimarchetti.bsky.social · Jun 10

Having a great day with the whole @ljrusselllab.bsky.social group, attending the @nucancer.bsky.social 2025 conference, showcasing excellent research from across the faculty, including some of our own from the #WolfsonCentre in the Herschel building, Alistair Poll and Melvin Joy. More to come later!

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Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group

Camille Drai @camilledrai.bsky.social · Jun 11

@ljrusselllab.bsky.social has crafted beautiful items for Children's Cancer North!

If you want to help this amazing charity, have a look at the shop :

Lunch Bag: shorturl.at/jvdLm
Phone Holder: shorturl.at/QbFXN
Pouch: shorturl.at/ryX6x

CCN Lunch Bag - Children's Cancer North

With this CCN lunch bag, you’re not only getting a beautifully hand-crafted accessory but also helping fund vital research and support children with cancer

childrenscancernorth.org.uk

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LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Jun 10

Great poster session by the LEGEND team. Lots of informative discussions had with other @nucancer.bsky.social colleagues.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · Jun 10

Great morning had at the @nucancer.bsky.social conference. Proud to see the work of the team presented as recent success stories coming from the centre.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · May 23

First time running a "Meet the Expert" session today at the European School for Haematology. Despite being nervous and not really knowing what to expect, I thoroughly enjoyed myself. I had a lovely group of attendees who made the experience one to remember.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · May 23

Privileged to have been asked to speak at this years ESH conference on acute lymphoblastic leukaemia in beautiful Malahide, Dublin. Great opportunity for extensive discussion and new collaborations.

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · May 22

Beyond the genome: Harnessing the power of super-enhancers for blood cancer - Cancer Research UK - Cancer News

The mysteries of the epiregulome need to be tackled head-on if we are to get new precision treatments for blood cancers

news.cancerresearchuk.org

6 6

LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · May 18

Well done to all the Wolfson Childhood Cancer Research Centre runners for completing the #ChildrensCancerRun today at Gosforth Park. @childcancernth.bsky.social @newcastleuni.bsky.social