Ricardo Mallarino
@mallarinolab.bsky.social
Associate Professor at Princeton University studying development, genetics, evolution, and everything in between. 🦇🦆🦘🐿️🐅🦎 www.mallarinolab.org
Reposted by Ricardo Mallarino
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Reposted by Ricardo Mallarino
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 7:55 PM
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Reposted by Ricardo Mallarino
As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out!
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
Great @currentbiology.bsky.social study by @xmikezheng20.bsky.social @cliffscience.bsky.social @arkarupbanerjee.bsky.social 🧪🧠🐭🎶
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
www.cell.com/current-biol...
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
www.cell.com/current-biol...
Vocal repertoire expansion in singing mice by co-opting a conserved midbrain circuit node
Zheng and Harpole et al. show that singing mice produce two major vocal modes: ancestral
USVs and novel songs that follow a linearly decelerating rhythm. Although acoustically
distinct, songs and USVs...
www.cell.com
November 19, 2025 at 6:42 PM
As a longtime fan of cool papers in @currentbiology.bsky.social, I am really thrilled to see this out!
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
This study sets the stage for understanding the origins of novel (vocal) behaviors.
Big shout out to the main architects of this work @xmikezheng20.bsky.social and @cliffscience.bsky.social
Reposted by Ricardo Mallarino
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
November 19, 2025 at 8:23 PM
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
Reposted by Ricardo Mallarino
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature
Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.
www.nature.com
October 15, 2025 at 3:52 PM
When Macrophages Disappear, Skin Blood Vessels Age!
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Check out our new study @nature.com that uncovers how the loss of capillary-associated macrophages with age blocks vessel repair and blood flow, revealing a new cellular trigger of tissue aging. #Aging #Immunology
👇👇
www.nature.com/articles/s41...
Reposted by Ricardo Mallarino
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
Insertion of an invading retrovirus regulates a novel color trait in swordtail fish
For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...
shorturl.at
November 12, 2025 at 8:34 PM
I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A
I’d given up on social media, but I was missing too many cool papers. Case in point: this incredible new study from @cagricevrim.bsky.social and @karalmckinley.bsky.social. Simply amazing!
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
November 12, 2025 at 6:29 PM
I’d given up on social media, but I was missing too many cool papers. Case in point: this incredible new study from @cagricevrim.bsky.social and @karalmckinley.bsky.social. Simply amazing!
A fascinating new study in which the humble sugar glider makes a special appearance, helping a team led by @brainevodevo.bsky.social and @fennak.bsky.social uncover the evolutionary history of a group of inhibitory neurons. Check out this thread summarizing the main findings!
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 12, 2025 at 6:19 PM
A fascinating new study in which the humble sugar glider makes a special appearance, helping a team led by @brainevodevo.bsky.social and @fennak.bsky.social uncover the evolutionary history of a group of inhibitory neurons. Check out this thread summarizing the main findings!