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Reposted by MANIFEST IO

Jon Lim, MRCP PhD @drjonlim.bsky.social · May 12

Want to know more about #MANIFESTuk?

To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery.

Check it out.
@manifest-cirrp.bsky.social

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Reposted by MANIFEST IO

Jon Lim, MRCP PhD @drjonlim.bsky.social · May 12

🚀 We finally had our first in-person #MANIFESTuk consortium meeting @crick.ac.uk today.

So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST.

Let’s keep going! 🙌
@manifest-cirrp.bsky.social

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

Our keynote speaker Elana Fertig (@univofmaryland.bsky.social) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

Ajitha Rajan (@edinburgh-uni.bsky.social) joins us over the web to present on “Multimodal Data Integration” 🔬

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

Up next, Santiago Zelenay (@cruk-mi.bsky.social) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

Anne-Laure Cattin (@crick.ac.uk) starts the third session presenting some amazing work on “Deconvoluting the in situ tumour immune microenvironment” 🧫🔬

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

Up next Dominic Rothwell (@cruknbc.bsky.social) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

James Jones (@cruk-ci.bsky.social) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥

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MANIFEST IO @manifest-cirrp.bsky.social · May 12

@maxemmerichderm.bsky.social (@crick.ac.uk) kicks off the second session presenting “Comprehensive blood profiling to derive immune signatures predictive of checkpoint inhibitor response and toxicity”. 🩸☢️

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Reposted by MANIFEST IO

Jon Lim, MRCP PhD @drjonlim.bsky.social · May 8

🎯 Delighted that the May 2025 issue of Cancer Discovery @theaacr.bsky.social features #MANIFESTuk!

Check out this ‘In Focus’ piece summarising our vision and ambitions for #CancerImmunotherapy 👇
aacrjournals.org/cancerdiscov...

@manifest-cirrp.bsky.social

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Reposted by MANIFEST IO

Jon Lim, MRCP PhD @drjonlim.bsky.social · Apr 14

💡Inspiring to be in amongst esteemed colleagues at BSI Cancer Immunotherapies Summit today at The Royal Society.

Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology.

@manifest-cirrp.bsky.social

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MANIFEST IO @manifest-cirrp.bsky.social · Mar 30

🚨Opportunity to join the MANIFEST team ‼️

We’re looking for:
💻 A Talented ML Engineer

To:
➡️ Join a team of computational biologists
💊Deliver on integrated immune-oncology biomarker signatures

📍@crick.ac.uk @TurajlicLab
🧑‍💻manifest-io.org.uk

Link 👇:

crick.wd3.myworkdayjobs.com/External/job/L…

https://crick.wd3.myworkdayjobs.com/External/job/L…

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MANIFEST IO @manifest-cirrp.bsky.social · Mar 25

Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event.

🏥 🧬 Criticial work will be led by colleagues & co-investigators:

🐝 @cruk-mi.bsky.social
🐝 @mcrcnews.bsky.social
🐝 @cruknbc.bsky.social
🐝 The Christie

Jon Lim, MRCP PhD @drjonlim.bsky.social · Mar 25

Great to see such a great turnout at our Manchester Immuno-Oncology Network (MION) 🐝 Spring event.

6️⃣ months in: Finally feel like I have arrived - presented my PhD work & also showcased @manifest-cirrp.bsky.social.

@mcrcnews.bsky.social
@giampazolias.bsky.social
@santiagozelenay.bsky.social

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Reposted by MANIFEST IO

Jon Lim, MRCP PhD @drjonlim.bsky.social · Feb 27

🚀 First set of results since launch of #MANIFESTuk - our wide-utility multiomic platform for cancer immunotherapy.

Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸.

Check it out 👇

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MANIFEST IO @manifest-cirrp.bsky.social · Feb 26

🚨First output from the MANIFEST platform‼️

🩸PBMC derived immune signatures can predict ICI response & tox!

🧑‍💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences

📍Watch this space for multimodal composite biomarkers

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MANIFEST IO @manifest-cirrp.bsky.social · Feb 16

Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25

Need for:

📊 Sample & Data Harmonisation
🔴 Overcome pervasive heterogeneity
🩸Incorporation of dynamic measures
🧠 Collaborative efforts

➡️ Generation of multimodal biomarker signatures

🧑‍💻: manifest-io.org.uk

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MANIFEST IO @manifest-cirrp.bsky.social · Feb 15

Fantastic to see integrated translational analyses presented on the podium at #GU25 🧬🔬

Elegantly presented by Prof Albiges

🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies

👇🏾

🧑‍💻manifest-io.org.uk

Zayd Tippu @zaydtippu.bsky.social · Feb 15

🚨🧬A translational start to D3 #GU25 🧬🚨

Final Survival Analysis: COSMIC-313

💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo
❌ Nil OS Benefit
‼️ Triplet limited by Tox:
⬇️ ICI # No & Dose

🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!

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MANIFEST IO @manifest-cirrp.bsky.social · Feb 14

🔦 Spotlight on ctDNA as Biomarker in Bladder Ca.

🔴 Emerging role as a surrogate for path response & survival ‼️

Need for:
💉 Prospective efforts w/ embedded sampling timepoints
🧑‍💻 Combinatorial Biomarkers
📊 Data Harmonisation

#GU25

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Reposted by MANIFEST IO

Zayd Tippu @zaydtippu.bsky.social · Feb 14

🚨Follow @manifest-cirrp.bsky.social

🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca

🧑🏾‍💻 manifest-io.org.uk

#GU25

Zayd Tippu @zaydtippu.bsky.social · Feb 14

Fantastic discussant session from @erplimackmd.bsky.social this morning at #GU25

🔍 Role of peri-op IO in MIBC: #CM274 & #NIAGRA

🧬 Biomarker need to optimise stratification and minimise risk of over-treatment

➡️ Emerging risk adapted integrated biomarker driven studies (MODERN)

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MANIFEST IO @manifest-cirrp.bsky.social · Feb 3

Excited to contribute to this space‼️

Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠

Great to see members of the consortium together at #Immuno25

Jon Lim, MRCP PhD @drjonlim.bsky.social · Jan 24

This morning, we heard all about biomarkers in cancer immunotherapy 🧬🔬🧪👨‍⚕️. #Immuno25

A comprehensive overview from the amazing @zaydtippu.bsky.social, who managed to package a complex field into 20mins 🙌.

Excited to see how @manifest-cirrp.bsky.social will hopefully contribute going forwards!

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MANIFEST IO @manifest-cirrp.bsky.social · Dec 27

🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk!

We are looking for:
💻 ML engineer
🔬 Senior Laboratory Research Scientist (Spatial Profiling)
🧑‍🔬 Senior Laboratory Research Scientist (Flow Cytometry)

Apply now 👉 www.crick.ac.uk/careers-and-...

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MANIFEST IO @manifest-cirrp.bsky.social · Dec 19

📅 Deadline: 8th January 2025

📝 Apply here: crick.ac.uk/careers-and-...

💻 Find out more: manifest-io.org.uk/about

Vacancies

Discover job opportunities at the Crick.

crick.ac.uk

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MANIFEST IO @manifest-cirrp.bsky.social · Dec 19

📢 New job opportunities open in computational modelling, genomics and imaging for Postdoctoral and Senior Scientists based @crick.ac.uk!

🧑‍🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy

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MANIFEST IO @manifest-cirrp.bsky.social · Dec 18

🦋 MANIFEST is excited to join the @bsky.app community!

🧑‍🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more

🤝 Together, we can advance cancer care for patients

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