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Maria Secrier

@mariasecrier.bsky.social

1.7K followers 260 following 9 posts

Cancer genomics, cellular plasticity, tumour microenvironment, digital pathology | Associate Professor and Group Leader @UCL | PhD from @EMBL | opinions my own https://secrierlab.github.io/

secrierlab.github.io

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Maria Secrier @mariasecrier.bsky.social · 2d

How do tissues organise, adapt, or collapse? 🧬
We’re looking for a postdoc with strong quantitative skills to tackle these questions in a highly interdisciplinary project bridging spatial omics, ecology & mathematical modelling (expertise required in at least one topic).
Apply 👉 tinyurl.com/3d37d3st

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk

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Maria Secrier @mariasecrier.bsky.social · 2d

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk

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Maria Secrier @mariasecrier.bsky.social · 21d

Come do some cool cell cycle science with the awesome @alexisbarr.bsky.social and me! 🔬✨

We’re looking for an enthusiastic computational biologist / data scientist (4-year postdoc) to dive into loads of cancer genomics & transcriptomics data.

Details below. Please share!

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Reposted by Maria Secrier

Alexis Barr @alexisbarr.bsky.social · 21d

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.

Deadline 15th October. Get in touch if you have any questions.

Please repost!

More details:
www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Maria Secrier @mariasecrier.bsky.social · Aug 12

We recently published a review reflecting on challenges and opportunities in characterising cancer cell states and niches using spatial transcriptomics and integration with digital pathology, see full thread below. Thank you Molecular Oncology for the opportunity!

Cenk Celik @cenkcelik.bsky.social · Jul 26

We, Secrier Lab UCL @ugiatucl.bsky.social Genetics Institute, discussed challenges in cell state identification using spatial transcriptomics in cancer research, now out in Molecular Oncology.
 doi.org/10.1002/1878... #SpatialTranscriptomics #CancerResearch #SpatialNiches

doi.org

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Reposted by Maria Secrier

cottonelucia.bsky.social @cottonelucia.bsky.social · Jun 9

🚨 We’re hiring a Postdoc!
Join our osteosarcoma research project @mariasecrier.bsky.social @fionafreeman.bsky.social. Funded by @littleprincesses.bsky.social 🧬🧫
🔹Cellular & molecular biology
🔹Cool 3D models

📍 UCL Cancer Institute, London
🗓️ July 1
📎 bit.ly/4kBCPt3
🌐 More info: lnkd.in/eahvf7Tg

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

bit.ly

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Maria Secrier @mariasecrier.bsky.social · Jun 2

Want to uncover biologically meaningful patterns in spatial omics data? Check out our new method EnrichMap, details below. Work led by the brilliant @cenkcelik.bsky.social! #spatialomics #genesets

Cenk Celik @cenkcelik.bsky.social · Jun 2

[Preprint alert]
We’re thrilled to introduce EnrichMap: a powerful new method for spatial gene set enrichment. It’s spatially aware, biologically meaningful and built for the next generation of spatial transcriptomics. www.biorxiv.org/content/10.1...

Description of a computational method for computing biological signals in spatial transcriptomics.

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Reposted by Maria Secrier

Joshua Bull @joshuabull.bsky.social · Apr 14

Are you looking for a postdoc position in #SpatialBiology?

We're advertising roles in both mathematical method development and in spatial data analysis @ox.ac.uk in colorectal precancer spatial biology!

Method Development: tinyurl.com/4vcbdjcy 🧮
Data Interpretation: tinyurl.com/yzsp729s 🧪

Job Details

my.corehr.com

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Reposted by Maria Secrier

Joshua Bull @joshuabull.bsky.social · May 1

In addition to the two #SpatialBiology posts in the thread below, we're now also advertising for a Research Software Engineer #RSE to help us take #MuSpAn to the next level - come and join us!

my.corehr.com/pls/uoxrecru...

#academic #jobs #softwaredeveloper #compsci

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Maria Secrier @mariasecrier.bsky.social · Apr 25

Attending #AACR2025 and interested in new ways of applying AI to make sense of single-cell and spatial omics data? Come hear me talk about our methods today at 5:15 pm in the "Accelerating Cancer Research with AI and Data Science Session" or connect with me afterwards.

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Maria Secrier @mariasecrier.bsky.social · Feb 27

Thank you for the invitation, it was a pleasure to discuss our recent work and I really enjoyed the stimulating ideas and feedback received! Looking forward to connecting further in the future.

Reposted by Maria Secrier

Max Telford @maxjtelford.bsky.social · Jan 23

Dear @guigau.bsky.social‬ and co-authors. Please see our very similar paper (not cited in yours as far as I can see) published 2018. Our software is called Croco!!! A citation would be nice!!!

bmcbiol.biomedcentral.com/articles/10....

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Maria Secrier @mariasecrier.bsky.social · Jan 2

New insights into the role of p21 in lung cancer from the fantastic @alexisbarr.bsky.social!

Alexis Barr @alexisbarr.bsky.social · Jan 2

New Year, new paper! (Ok, it actually came out just before Christmas but who was working then?!)

Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU

Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer

British Journal of Cancer - Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer

rdcu.be

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Maria Secrier @mariasecrier.bsky.social · Dec 2

Developed by my brilliant PhD student, Eloise Withnell, we use SpottedPy to explore EMT plasticity in breast primary tumours and uncover a hybrid, quasi-mesenchymal E/M state linked with immune evasion. #cancer #spatialtranscriptomics #EMT

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Maria Secrier @mariasecrier.bsky.social · Dec 2

Delighted to introduce our new spatial transcriptomics tool, SpottedPy, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10....

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Reposted by Maria Secrier

David Basanta @cancerevo.org · Nov 26

As a member of @smbmathbiology.bsky.social (and podcast fan) I listen to all of these, best way to keep up with the #science and the #scientists in #MathBio other than those I usually obsess about #MathOnco #MathEvo

Parmvir K Bahia @parmvir.com · Nov 26

I suppose now is a good time to introduce #BiologyInNumbers, a #SciComm podcast I have the pleasure of directing, producing & hosting. Thought up by then-President Heiko Enderling, it's a means to learn about @smbmathbiology.bsky.social and research from its members and the wider #mathBio community.

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