Matthieu Najm
@mattanajm.bsky.social
29 followers 47 following 5 posts
Postodoctoral researcher in computational systems biology @ Institut Pasteur
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Reposted by Matthieu Najm
lgaspardboulinc.bsky.social
Can't wait to be at @jobim2025.bsky.social #JOBIM25 to present a short demo on the companion ShinyApp (shorturl.at/Os7kB) of our review "Cell-type deconvolution for spatial transcriptomics" recently published in @natrevgenet.nature.com ! #spatial #genomics
Deconvolution toolbox for spatial transcriptomics
shorturl.at
Reposted by Matthieu Najm
Reposted by Matthieu Najm
slobentanzer.bsky.social
Yes, there's "accessible" in my group's title. Come at me, Trump!

Just kidding, don't come at me, except if you're looking for a job in biomedical AI. Hiring at all levels, up to 100% of E13.

If you're enthusiastic about science and open source, consider applying! Please help spread the word. :)
Reposted by Matthieu Najm
kcharniga.bsky.social
Big turnout today in Paris to show solidarity with US-based scientists ❤️ 🗽 #StandUpforScienceFrance @pasteur.fr
Reposted by Matthieu Najm
theomaire.bsky.social
Very grateful to have been awarded a #MSCA post-doc fellowship! With Felix Hol and Teun Bousema, we will bring BuzzWatch to the field to study mosquito behavior in malaria-endemic regions.

Starting in #RadboudUmc, our first goal is to make BuzzWatch portable enough to be transported by bicycle 🦟🚲🇳🇱.
Reposted by Matthieu Najm
saezlab.bsky.social
Applying LLMs to biomedical research today can go one of two ways: we either use a closed-source web app, or we get coding ourselves. Many researchers lack training for the latter, so their only choice is the former. We want to change that. www.nature.com/articles/s41...
Graphical abstract of BioChatter
Reposted by Matthieu Najm
gabrielpeyre.bsky.social
The Mathematics of Artificial Intelligence: In this introductory and highly subjective survey, aimed at a general mathematical audience, I showcase some key theoretical concepts underlying recent advancements in machine learning. arxiv.org/abs/2501.10465
mattanajm.bsky.social
Thank you to my PhD supervisors at the Center for Computational Biology at Mines Paris and the Computational Systems Biology Group at Institut Curie. Grateful for our collaborators at Institut Necker Enfants Malade and the support from Vaincre La Mucoviscidose. 5/5
mattanajm.bsky.social
If you are interested in CFTR interactors and the consequences of the absence of CFTR on signalling pathways, you can explore the Shiny application at njmmatthieu.shinyapps.io/shinyapp/ for convenient browsing of the CF network. 4/5
mattanajm.bsky.social
Finally, an important contribution of the present work is that the adopted global methodology of the CF context can be used as a common framework for other monogenic diseases. 3/5
mattanajm.bsky.social
We adopted a data-driven systems biology approach to retrieve CF dysregulated signalling pathways. Our findings point to candidate therapeutic targets such as SYK and PI3KCA, for which specific inhibitors are already known. 2/5
mattanajm.bsky.social
Excited to share the final work from my PhD: our study on developing a signalling network gathering the molecular dysregulations caused by the absence of CFTR in cystic fibrosis (CF).
Read the full article published in the journal BMC Genomics at: doi.org/10.1186/s128... 1/5
From CFTR to a CF signalling network: a systems biology approach to study Cystic Fibrosis - BMC Genomics
Background Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the gene coding the Cystic Fibrosis Transmembrane Regulator (CFTR) protein, but its overall physio-pathology cannot be sol...
doi.org