Maximilian Heeg
@maximilian.heeg.io
Assistant Investigator at @alleninstitute.bsky.social | Former postdoc @GoldrathLab | Pediatrician | Interested in tissue resident memory T cells and Immunodeficiencies | Mountain enthusiast ⛰ | 🐕
#immunology
Personal website: www.heeg.io
#immunology
Personal website: www.heeg.io
🧵 4/10 This diversity is regulated by:
1. Distinct ligand-receptor activities
2. Spatial cytokine gradients
3. Specialized cellular contacts creating a complex molecular landscape that guides TRM differentiation
1. Distinct ligand-receptor activities
2. Spatial cytokine gradients
3. Specialized cellular contacts creating a complex molecular landscape that guides TRM differentiation
January 22, 2025 at 4:15 PM
🧵 4/10 This diversity is regulated by:
1. Distinct ligand-receptor activities
2. Spatial cytokine gradients
3. Specialized cellular contacts creating a complex molecular landscape that guides TRM differentiation
1. Distinct ligand-receptor activities
2. Spatial cytokine gradients
3. Specialized cellular contacts creating a complex molecular landscape that guides TRM differentiation
🧵 2/10 Using spatial transcriptomics (Xenium & MERSCOPE), we discovered that intestinal TRM cells occupy distinct niches that shape their phenotype and function. We developed computational approaches to map cells along three anatomical axes 📊
January 22, 2025 at 4:15 PM
🧵 2/10 Using spatial transcriptomics (Xenium & MERSCOPE), we discovered that intestinal TRM cells occupy distinct niches that shape their phenotype and function. We developed computational approaches to map cells along three anatomical axes 📊