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Reposted by Mazen Kheirbek

Martin Kampmann @kampmann.bsky.social · 23d

Apply by Oct 15 - please spread the word!

Martin Kampmann @kampmann.bsky.social · Jul 23

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

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Mazen Kheirbek @mazenkheirbek.bsky.social · Jul 30

New paper from the lab, from Jeremy Biane and team, out today, characterizing the principles of stimulus feature coding in populations of ventral CA1 neurons.

Neuron @cp-neuron.bsky.social · Jul 30

Online now:

Representations of stimulus features in the ventral hippocampus

The ventral hippocampus (vHPC) controls emotional response to environmental cues, yet the mechanisms are unclear. Biane et al. examine how positive and negative experiences are encoded by vHPC ensembles, showing that vCA1 does not contain generalized representations of valence but rather discriminates salient stimuli based on their identity and sensory features.

dlvr.it

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Vikaas Sohal @vikaassohal.bsky.social · Jun 30

New work! Learning is assumed to involve synaptic plasticity, but which specific synapses change to enable higher order cognitive functions? We actually find that cognitive flexibility involves potentiation of long-range GABAergic synapses from prefrontal PV neurons: www.biorxiv.org/content/10.1...

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility

While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...

www.biorxiv.org

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Alexandra Klein @aexolowski.bsky.social · May 14

Come to our symposium tomorrow morning at #NeuroFrance2025 if you want to hear about extero- and interoceptive impact on emotions!

Meryl Malezieux @merylneuro.bsky.social · May 14

If you're attending #NeuroFrance2025 in beautiful Montpellier and you're interested in sensory processing and emotions, don't miss out our symposium tomorrow (Thursday) morning! Organized together with @mariocarta.bsky.social
@socneuro.bsky.social

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Josh Johansen @jojolab.bsky.social · May 14

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8)

rdcu.be/el19t

Prefrontal encoding of an internal model for emotional inference

Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.

rdcu.be

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Paul Frankland @franklandlab.bsky.social · May 14

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

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Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

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Alex Kwan @alexkwan.bsky.social · Apr 9

A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄

@theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏

www.biorxiv.org/content/10.1...

A multi-institutional investigation of psilocybin's effects on mouse behavior

Studies reporting novel therapeutic effects of psychedelic drugs are rapidly emerging. However, the reproducibility and reliability of these findings could remain uncertain for years. Here, we impleme...

www.biorxiv.org

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AntonioFR @antferrui.bsky.social · Mar 17

Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks

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Kate Wassum @katewassum.bsky.social · Feb 19

🚨📃New Wassum Lab Paper📃🚨

Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇

www.nature.com/articles/s41...

Free full text: rdcu.be/eaxEv

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

www.nature.com

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Saul Kato @focolab.bsky.social · Jan 14

For our inaugural post on bsky, we're happy to share our preprint on tardigrades as a new model organism for neuroscience. Exciting times for these little critters! www.focolab.org/post/our-pre...

Our preprint "The tardigrade as an emerging model organism for systems neuroscience" is up.

We have been making the case for some time that tardigrades, aka water bears, would be an amazing new model organism for certain big systems neuroscience questions. We put this into a detailed paper o...

www.focolab.org

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Paul Frankland @franklandlab.bsky.social · Dec 17

Scientist position at The Hospital for Sick Children in Toronto. We are looking for neuroscientists with interests in the molecular and cellular bases of cognition. The position is open-rank, and the successful candidate will also be appointed at U Toronto. Deadline is Feb 15th. Come join us!

career.sickkids.ca

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Josh Johansen @jojolab.bsky.social · Dec 8

Check out our pre-print from Xiaowei Gu! It shows how the medial prefrontal cortex encodes an internal model of emotional associations which can be used for inference
biorxiv.org/content/10.1...

biorxiv.org

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 5

Thank you!

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 5

Thank you!

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PessoaBrain @pessoabrain.bsky.social · Dec 5

𝗨𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗻𝗲𝘂𝗿𝗮𝗹 𝗰𝗼𝗱𝗲 𝗼𝗳 𝘀𝘁𝗿𝗲𝘀𝘀 𝘁𝗼 𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝗮𝗻𝗵𝗲𝗱𝗼𝗻𝗶𝗮
Looks like a very cool paper.
#neuroscience
doi.org/10.1038/s415...

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stefanofusi.bsky.social @stefanofusi.bsky.social · Dec 4

A beautiful work with a wonderful team! A lot of new ideas and a huge number of elegant experiments

Frances Xia @fxia.bsky.social · Dec 4

Excited to share our new paper out now @natureportfolio.bsky.social, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia!

Thread below:

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Frances Xia @fxia.bsky.social · Dec 4

Excited to share our new paper out now @natureportfolio.bsky.social, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia!

Thread below:

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Valeria Fascianelli @valeriafascianelli.bsky.social · Dec 4

What is the neural code and statistical structure of neural states characterizing stress?
Our new work in Nature answers these questions and more. Thanks to my amazing co-first @fxia.bsky.social @stefanofusi.bsky.social @mazenkheirbek.bsky.social for precious guidance
www.nature.com/articles/s41...

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 4

Huge congrats to the rest of the team: Nina Vishwakarma, Frances Ghinger, Andrew Kwon, @markgergues.bsky.social and Lahin Lalani!

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 4

A couple news articles by @ucsfhealth.bsky.social and @natureportfolio.bsky.social here:
www.ucsf.edu/news/2024/12...
www.nature.com/articles/d41...

Stress can dull our capacity for joy: mouse brain patterns hint at why

Scientists pinpoint brain circuits linked to either resilience or vulnerability to adversity, which affect a stressed animal’s pursuit of pleasure.

www.nature.com

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 4

Thread by @fxia.bsky.social here:
bsky.app/profile/fxia...

Frances Xia @fxia.bsky.social · Dec 4

Excited to share our new paper out now @natureportfolio.bsky.social, where we identified neural signatures of stress susceptibility and resilience in the amygdala-ventral hippocampal network to enable control of anhedonia!

Thread below:

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Mazen Kheirbek @mazenkheirbek.bsky.social · Dec 4

I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...

Understanding the neural code of stress to control anhedonia - Nature

Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...

www.nature.com

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