New Molecular Metabolism study from the Biddinger Lab finds diabetes gene TCF7L2 is crucial for hepatic zonation and glutamine metabolism. Liver-specific Tcf7l2 knockout mice exhibit metabolic reprogramming, and decreased glutamine in humans with the rs7903146 variant. #BiddingerLab
hsph.me/Tcf7l2

Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out
rdcu.be/eBbqV

Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.

🚨The final programme for #FusionAging25 is now live
⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days!

🗓️Final Poster & Reg Deadline: 07 Aug 2025
🔗 bit.ly/3FR0Z3E
#FusionAgingResearch

Just two of thousands of such stories. substack.com/home/post/p-...

Using a phospho-mutant TSC2-5A mouse, the work reveals tissue-specific roles for this pathway in organ growth, including reduced brain and muscle size. Congratulations to all contributing researchers on this important publication! #Metabolism #ManningLab

New study in @cp-devcell.bsky.social from the @bdmanning.bsky.social Lab.
‪ @yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...

For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters

From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more:
hsph.me/mitoT2D

🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social

A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!

See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm

This study has advanced the frontier of in vivo flux quantification, offering important tools and resources for metabolic research. Incredible work by all researchers involved! #Metabolism #ObesityResearch

Exciting findings from Bo Yuan, PhD of the @tonyhui.bsky.social Lab: a whole-body quantitative flux model of energy metabolism was built, revealing surprising features of energy metabolism in both normal physiology and obesity. Great collaboration with the Hotamışlıgil Lab!

Great work, led by Dr. Hotamisligil, Postdoctoral Fellow Dr. Baazim and the research team!

Publication in @embomolmed.org identifies FABP4 as a key host factor regulating SARS-CoV-2 replication, inflammation and lung damage. Providing a promising treatment candidate. #COVID19Research #Metabolism #HotamisligilLab
www.embopress.org/doi/full/10....

Great work by @mariesabatier.bsky.social,Jessalyn Ubellacker, Ani Solanki, Sangeetha Thangaswamy, Pin-ji Lei, Hengbo Zhou, Meghan O’Melia, Lutz Menzel, and Samir Mitri!

@ubellackerlab.bsky.social in Nature Protocols, details new protocol for collecting lymph and tumor-draining lymph from mouse models of cancer metastasis. This method enables multiomic profiling of lymph-derived cancer cells, revealing the impact of the lymphatic environment on cancer progression.