middletonsj.bsky.social
Steve Middleton
@middletonsj.bsky.social
54 followers 97 following 2 posts
Post Doc • Bennett Lab • Pain and Sensory Biology • Research Fellow, @WolfsonCollege • University of Oxford • 🏳️‍🌈
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middletonsj.bsky.social
Steve Middleton @middletonsj.bsky.social · Aug 21
Massive thanks to everyone involved! Especially, the Bennett group @ndcnoxford.bsky.social and the Newstead team @kavlioxford.bsky.social @oxfordbiochemistry.bsky.social. Big shout out to my co-first author @sigurbjornm.bsky.social!
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middletonsj.bsky.social
Steve Middleton @middletonsj.bsky.social · Aug 21
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!

www.nature.com/articles/s41...
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
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Reposted by Steve Middleton
sigurbjornm.bsky.social
Sigurbjörn Markússon @sigurbjornm.bsky.social · Aug 21
Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
1 7 17
Reposted by Steve Middleton
ndcnoxford.bsky.social
Nuffield Department of Clinical Neurosciences @ndcnoxford.bsky.social · Aug 21
📣 NEW: Breakthrough discovery of a genetic link to pain co-led by NDCN's Prof David Bennett and Prof Simon Newstead @oxfordbiochemistry.bsky.social

The results of the research, published in @nature.com, could lead to a promising new target for the treatment of #chronicpain.
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