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mikhailshapiro.bsky.social
Mikhail Shapiro
@mikhailshapiro.bsky.social
840 followers 230 following 2 posts
Bio-Acousto-Magneto-Neuro-Chemical Engineer Max Delbrück Professor @Caltech Investigator @HHMI Fulbright-Tocqueville Chair @PhysMedParis @ESPCI_Paris '24-5 shapirolab.caltech.edu
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mikhailshapiro.bsky.social
Mikhail Shapiro @mikhailshapiro.bsky.social · Dec 23
Can we make a brain tumor visible under ultrasound? 🧠 🔉 Yes, using intravenous #gasvesicles! This can help guide brain surgery and monitor for tumor recurrence.
Congrats to Claire Rabut, George Daghlian and collaborators!
www.biorxiv.org/content/10.1...
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Reposted by Mikhail Shapiro
jerzyszablowski.bsky.social
Jerzy Szablowski @jerzyszablowski.bsky.social · Dec 12
qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification.
www.biorxiv.org/content/10.1...
Schematic explaining In vivo tracking of active transcription. Injection of gene therapy is followed by measurement of the transcripts with RNA sensors, which produce a synthetic serum marker called RMA.
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mikhailshapiro.bsky.social
Mikhail Shapiro @mikhailshapiro.bsky.social · Nov 18
What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain! 🧠
Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" ultrasound. 🥟 #gasvesicles www.biorxiv.org/content/10.1...
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