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Melissa Call

@mjcall.bsky.social

66 followers 43 following 10 posts

Associate Professor, @ WEHI, Melbourne AU. Structural immunologist and deep mutational scanning enthusiast.

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Reposted by Melissa Call

Wai-Hong Tham @thamlab.bsky.social · Aug 1

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗

🦟 Transgenic parasites without Pfs230 D13D14 do not transmit

🦙 💉Nanobodies + mRNA induced antibodies reduce transmission

New in @Science.org

www.science.org/doi/10.1126/...

#ScienceResearch #Malaria #WEHI

Melissa Call @mjcall.bsky.social · Feb 11

*misfolding

Melissa Call @mjcall.bsky.social · Feb 11

The battle of the decades is complete. Thank you Leann Tilley for the excellent chairing and all the speakers for a fun session. @lorneproteins.bsky.social

Melissa Call @mjcall.bsky.social · Feb 11

James Whisstock takes us to the present day highlighting some of the coolest techniques presented at #Lorneproteins in the past decade.

Melissa Call @mjcall.bsky.social · Feb 11

A Protein structure was not enough to get a talk by the early-mid 2000s (unless it was a membrane protein :-) ) Jacqui Matthews @lorneproteins.bsky.social

Melissa Call @mjcall.bsky.social · Feb 11

Protein missing is pretty important - Robin Anders @lorneproteins.bsky.social

Melissa Call @mjcall.bsky.social · Feb 11

Marilyn Anderson reminisces on the beginning of Protein design in the late 80s #Lorneproteins @lorneproteins.bsky.social

Melissa Call @mjcall.bsky.social · Feb 11

Lindsay Sparrow tells us there was only 23 structures in the PDB when #Lorneproteins started in 1976! @lorneproteins.bsky.social

Melissa Call @mjcall.bsky.social · Feb 9

Congratulations Frances Separovic on winning the Leach Medal - #lorneproteins

Melissa Call @mjcall.bsky.social · Feb 9

Deb Leach sharing her thoughts on her father, Syd Leach, who started #Lorneproteins

Melissa Call @mjcall.bsky.social · Feb 9

The 50th Lorne Conference on Protein Structure and Function - Beautiful Welcome to Country #lorneproteins

Reposted by Melissa Call

bioRxivpreprint @biorxivpreprint.bsky.social · Dec 23

Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy https://www.biorxiv.org/content/10.1101/2024.12.22.629940v1

Reposted by Melissa Call

Bird account @dialecticbio.bsky.social · Dec 6

Scalable emulation of protein equilibrium ensembles with
generative deep learning www.biorxiv.org/content/10.1...

No code is available yet, but sounds huge. Effectively does MD-sim, but fast!

Fig. 1 Overview of model and architecture. a) Actin conformational changes and filament formation / dissociation as an example
for the mechanistic basis of protein function. b) ML model architecture consisting of protein sequence encoder and denoising
diffusion model. The diffusion model samples coarse-grained protein structures from an approximate equilibrium distribution, from
which properties such as free energy differences can be computed. c) Architecture of the score model used in the denoising diffusion
model. d) Data integration and model training pipeline. e) Data processing pipeline for pretraining. f) Experimental property
training for finetuning

Reposted by Melissa Call

Seth Thomas Scanlon @immunoeditor.bsky.social · Dec 3

ICYMI: this really interesting @science.org paper on possible underlying mechanisms of post-accute #COVID19 syndrome ( #PACS ) aka " #LongCOVID" from last January!

Sarah Ross @sarahhross.bsky.social · Dec 2

ICYMI: Analysis of blood serum found #LongCOVID was characterized by altered levels of certain immune complement proteins. These changes linked to complement activation and signs of dysregulation of the coagulation system. #Immunosky

www.science.org/doi/10.1126/...

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid

Analysis of blood revealed that Long COVID is characterized by changes to complement proteins and platelet activation.

www.science.org

Reposted by Melissa Call

ross @rosscloney.bsky.social · Nov 29

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells

www.nature.com/articles/s41...

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells - Nature Communications

Context-dependent, responsive synthetic promoters are crucial for a wide range of applications, yet currently available options are limited. Here, authors develop a library of thousands of candidate p...

Reposted by Melissa Call

bioRxivpreprint @biorxivpreprint.bsky.social · Nov 30

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1

Chimeric antigen receptors (CAR) that mimic T cell receptors (TCR) on eliciting peptide-major histoc

www.biorxiv.org

Reposted by Melissa Call

bioRxivpreprint @biorxivpreprint.bsky.social · Nov 30

Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1

Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1

Background: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape o

www.biorxiv.org

Reposted by Melissa Call

Bird account @dialecticbio.bsky.social · Nov 30

Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1...

New from the Baker lab

Diffusion of pMHC binders

Reposted by Melissa Call

Vega Shah @dr-alphalyrae.bsky.social · Nov 25

A major step forward toward high-resolution nanopore sequencing of full-length proteins www.cell.com/molecular-ce...

A major step forward toward high-resolution nanopore sequencing of full-length proteins

In a recent publication in Nature, Motone et al. report the development of a protein sequencing method using nanopores that enables the reading of long protein strands. This method allows for multi-pa...

Reposted by Melissa Call

Fiona Whelan @freewhelan.bsky.social · Nov 18

C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts.
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org

Lorne Proteins 2025

lorneproteins.org