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Murray Green @murraybgreen.bsky.social · 8d

"Diagnostic disparities in ambulatory care" - solving these with POC multiplex Resp PCR - no need for a lab!!

The silent surge: the under-recognised burden of respiratory syncytial... www.sciencedirect.com/science/arti...

The silent surge: the under-recognised burden of respiratory syncytial virus, human metapneumovirus, and parainfluenza viruses in adults

Respiratory syncytial virus (RSV), human metapneumovirus (HMPV), and parainfluenza viruses (PIV) drive substantial morbidity in adults, yet remain und…

www.sciencedirect.com

Murray Green @murraybgreen.bsky.social · Aug 5

Great piece of work by the RCH Melbourne Team.
These kids need all the help they can get!
pubmed.ncbi.nlm.nih.gov/40751318/

Utility of BioFire FilmArray Pneumonia Panel Plus in a High-Risk Cohort: Children Post Allogeneic Stem Cell Transplantation - PubMed

In conclusion, we report the first prospective evaluation of the diagnostic performance of the FA-PP in BAL, in a high-risk paediatric HCT cohort. We demonstrate that the FA-PP is a potentially useful...

pubmed.ncbi.nlm.nih.gov

Murray Green @murraybgreen.bsky.social · Jul 25

I know who needs to see this... It's the vast majority of presenters that I have seen recently start their PPT show with Presenter View the wrong way around.
This is all you need to do to swap screens - & not lose me in the first 10 seconds of your talk...
(Source: superuser.com/questions/11...)

Murray Green @murraybgreen.bsky.social · Jul 16

Winding back the years at #ASM2025

Murray Green @murraybgreen.bsky.social · Jul 5

This week’s highlights:
1. Paed ED said “my phone is full of photos of poo”.
2. Sent an ID Prof a Caddyshack DVD.

Murray Green @murraybgreen.bsky.social · Jun 20

#POC25 Cheryl Johnson (Ngati Porou Oranga, NZ) on Indigenous Community-led Point of Care Testing: Cervical screening (pap smears) was not well adopted by Māori women who didn't like speculums. So self-collected swabs for HPV POCT is called "The Selfie" - brilliant! Increased screening is good.

Murray Green @murraybgreen.bsky.social · Jun 20

#POC25: "Learn, unlearn and relearn" is Nikki Pant Pai's catch cry. We need to unlearn that molecular testing can only be done in laboratories.

Murray Green @murraybgreen.bsky.social · May 22

Very well done!

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · May 21

Could this be a breakthrough in ID?
Top-line results from diSArm, the first Phase 1b/2a RCT of IV phage therapy (Armata’s AP-SA02) in SA bacteremia showed 88% clinical response at day 12 TOCD12(vs 58% BAT,p=0.047) & 100% response at EOS (vs 25% BAT) #idsky
www.stocktitan.net/news/ARMP/ar...

Armata Pharmaceuticals Announces Positive Topline Data from the Phase 1b/2a diSArm Study of Intravenously Administered AP-SA02 in Complicated Staphylococcus aureus Bacteremia

All primary endpoints for safety, tolerability, and clinical response in the intent-to-treat population met. AP-SA02 arm significantly improved clinical outcomes and prevented relapse compared to best...

www.stocktitan.net

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Murray Green @murraybgreen.bsky.social · Apr 30

(TGA-registered POC molecular test now available!👋)

Pediatric Invasive Group A Streptococcal Infections Show Post-Pandemic Surge in Children www.medscape.com/viewarticle/...

Post-Pandemic Surge of Group A Strep Infections in Children

Cases of invasive group A streptococcal infections in children varied during time periods before the pandemic, declined during it, and resurged in 2023 in Canada, as per data collected over 32 years.

www.medscape.com

Murray Green @murraybgreen.bsky.social · Apr 30

Yep! Phages, new drugs, mAbs, etc - Regulators (and funders) need to get pragmatic.

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Murray Green @murraybgreen.bsky.social · Apr 30

www.360dx.com/molecular-di...

WHO Recommends PCR Testing in 'First Ever' Global Meningitis Guidelines

PCR should be performed on cerebrospinal fluid samples to guide meningitis care, WHO said.

www.360dx.com

Murray Green @murraybgreen.bsky.social · Apr 30

That's an important but slippery slope. How much blame can we apportion to the regulators for the AMR hole we find ourselves in? It's step 1 on the game board - and modern medical industry can't open the old/outdated locks.

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Murray Green @murraybgreen.bsky.social · Apr 28

Dengue Outbreaks: The Growing Threat and Global Response (single-shot vax in PhIII)

www.medscape.com/viewarticle/...

Dengue Outbreaks: The Growing Threat and Global Response

Dengue’s rise in 2024, influenced by climate change and shifting serotypes, underscores the need for effective vaccines to curb the expanding global threat.

www.medscape.com

Murray Green @murraybgreen.bsky.social · Apr 28

Surveillance of wastewater (sewerage) for infections - support earlier public health interventions!

www.biomerieux.com/corp/en/jour...

WATCHFIRE™ by bioMérieux: a PCR test to detect viruses and bacteria in wastewater and respond to potential infectious disease outbreaks

bioMérieux, a world leader in the field of in vitro diagnostics, today announces the launch of its WATCHFIRE™ molecular testing solution. The WATCHFIRE™ Respiratory (R) Panel, targeting 22 pathogens*,...

www.biomerieux.com

Murray Green @murraybgreen.bsky.social · Apr 3

#ASID2025 session on Aus CDC moving from Interim to Full 😁; while we hear about USA CDC decimation at the hands of Trump and DOGE 😱🤡

Murray Green @murraybgreen.bsky.social · Apr 3

Ushma Wadia (PCH): RSV vaccine rollout in WA slashes admissions, saves a ton of money (and parent stress) and safety looks good through monitoring systems.

Murray Green @murraybgreen.bsky.social · Apr 3

Pat Harris letting us down gently with the early tarnish on some of the lauded new anti-Gram neg agents at #ASID2025 (is that a tag?).

There’s a goodish one, for $7k per day (hospital administrators, time to clutch your pearls)

Murray Green @murraybgreen.bsky.social · Mar 14

Can I eat them after you've extracted the magic juice?
www.medscape.com/viewarticle/...

The Surprising Source of Next-Gen Antibiotics: Oyster Blood

Fascinating new research shows mollusk blood proteins have strong antimicrobial properties, especially when combined with existing antibiotics.

www.medscape.com

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Murray Green @murraybgreen.bsky.social · Feb 20

Giske: beware using Cefiderocol discs in MBL strains - many isolates are S by MIC but in ATU (uncertain) on disc, resulting in over-calling of resistance.
#antimicrobials2025

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Murray Green @murraybgreen.bsky.social · Feb 20

She also notes, we don’t need more "lab in a box" PCR systems; we need 3-5-10 yr funding models to keep them online AND serviced in conflict zones (tricky)

Murray Green @murraybgreen.bsky.social · Feb 20

(Thx Nadine again)
Thinking about AMR - even in the safety of Australia - can be depressing.
Talking about AMR - and healthcare attacks in war zones - is factorially worse.
Thanks for sharing @catanita.bsky.social

Nadine Hillock @nadinehillock.bsky.social · Feb 20

More than half of the Gm-negative infections in soldiers in the Ukraine conflict are resistant to carbapenems - fascinating presentation on #AMR in conflict settings from @catanita.bsky.social
#antimicrobials2025 #ASA2025 #globalpublichealth #MDRI

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Murray Green @murraybgreen.bsky.social · Feb 19

Starting off ASA and my theory that everyone must open/ice-break/mention AI in their talk is holding true.
Will someone omit it?
(Great explainer on how to better optimise therapy beyond TDM, and who to focus your efforts on)

Nadine Hillock @nadinehillock.bsky.social · Feb 19

Dr Erin McCreary kicking off with the first plenary for #Antimicrobials2025 in Melbourne ‘Precision dosing in complex & critically ill patients’ #ASA2025 #antimicrobials

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Murray Green @murraybgreen.bsky.social · Feb 16

Flu is now 23% of all respiratory detections in USA - from the BioFire Syndromic Trends program (Feb 17th)
www.syndromictrends.com

Murray Green @murraybgreen.bsky.social · Feb 13

Change treatment in nearly half of PICU patients within a few hours. Escalation and de-escalation. An AMS dream come true??

journals.lww.com/pidj/abstrac...

Potential Impact of Rapid Molecular Microbiologic Diagnosis ... : The Pediatric Infectious Disease Journal

-based methods are labor- and time-intensive. Emerging molecular diagnostic tools may identify pathogens and detect antimicrobial resistance more quickly, to enable earlier targeted antimicrobial ther...

journals.lww.com

Murray Green @murraybgreen.bsky.social · Feb 3

Take it up with the FDA…