Nikos Konstantinides
@nkonst4.bsky.social
Reposted by Nikos Konstantinides
Apply for a PhD in Paris!! A project to come and work with me and my team at the GutSense lab included in the list! 🪰🧠⛽
📚 The international DIM C-BRAINS PhD program is back!
Up for grabs: 7 fully funded, 3-year doctoral contracts in the Île-de-France region, 3 of which will be hosted by Paris Brain Institute.
📆 Application deadline: February 1, 2026.
👉 Find out more: parisbraininstitute.org/dim-c-brains...
Up for grabs: 7 fully funded, 3-year doctoral contracts in the Île-de-France region, 3 of which will be hosted by Paris Brain Institute.
📆 Application deadline: February 1, 2026.
👉 Find out more: parisbraininstitute.org/dim-c-brains...
The DIM C-BRAINS international PhD program opens its 2026 call for applications. | Paris Brain Institute
The international DIM C-BRAINS PhD program is back. Up for grabs: 7 fully funded, 3-year doctoral contracts in the Île-de-France region, 3 of which will be hosted by the Institut du Cerveau. Applicati...
parisbraininstitute.org
December 5, 2025 at 5:13 PM
Apply for a PhD in Paris!! A project to come and work with me and my team at the GutSense lab included in the list! 🪰🧠⛽
Cool preprint from the lab of Raouf Issa at ESPCI in Paris with a small contribution from our lab at @ijmonod.bsky.social
Padmanabhan et al found that a specific set of Drosophila dopamine neurons, which is already active in embryos and stays functionally important for locomotion throughout life.
Padmanabhan et al found that a specific set of Drosophila dopamine neurons, which is already active in embryos and stays functionally important for locomotion throughout life.
Lifelong maintenance of locomotion by embryonically active dopamine neurons https://www.biorxiv.org/content/10.64898/2025.11.28.691140v1
December 3, 2025 at 9:43 AM
Cool preprint from the lab of Raouf Issa at ESPCI in Paris with a small contribution from our lab at @ijmonod.bsky.social
Padmanabhan et al found that a specific set of Drosophila dopamine neurons, which is already active in embryos and stays functionally important for locomotion throughout life.
Padmanabhan et al found that a specific set of Drosophila dopamine neurons, which is already active in embryos and stays functionally important for locomotion throughout life.
Reposted by Nikos Konstantinides
Having witnessed many HHMI labs during my postdoc, my impression was that many of them struggled to even productively spend all their money.
At some point it seems logical that you just hit diminishing returns; systematic studies have come to the same conclusion. www.science.org/content/blog...
At some point it seems logical that you just hit diminishing returns; systematic studies have come to the same conclusion. www.science.org/content/blog...
Research output as a function of grant support: The scatter matters
www.science.org
November 29, 2025 at 12:43 PM
Having witnessed many HHMI labs during my postdoc, my impression was that many of them struggled to even productively spend all their money.
At some point it seems logical that you just hit diminishing returns; systematic studies have come to the same conclusion. www.science.org/content/blog...
At some point it seems logical that you just hit diminishing returns; systematic studies have come to the same conclusion. www.science.org/content/blog...
Reposted by Nikos Konstantinides
***Super cool-project alert***⚠️ Come work with @dirkmetzler.bsky.social and me in trying to understand how transcriptional noise evolves in a phylogenetic context 🧬 Deadline 15th Dec 2025 (Project funded by @dfg.de @gevol.bsky.social)
PhD position available for theoretical and statistical modeling in my joint @gevol.bsky.social project with @luisapallares.bsky.social on the evolution of transcriptional variability and its role in adaptation and evolutionary innovation.
See
job-portal.lmu.de/jobposting/6...
See
job-portal.lmu.de/jobposting/6...
PhD candidate in biology — theoretical and statistical modeling (m/f/x)
job-portal.lmu.de
November 27, 2025 at 2:30 AM
***Super cool-project alert***⚠️ Come work with @dirkmetzler.bsky.social and me in trying to understand how transcriptional noise evolves in a phylogenetic context 🧬 Deadline 15th Dec 2025 (Project funded by @dfg.de @gevol.bsky.social)
Paris in the top-5 bike-friendly cities in the world ❤️ www.paris.fr/pages/paris-...
Paris rentre dans le top 5 des villes cyclables
La capitale française décroche la 5e place mondiale dans l’index international des villes cyclables du cabinet Copenhagenize. Paris est en 2e position pour la qualité de son infrastructure cyclable.
www.paris.fr
November 21, 2025 at 6:44 PM
Paris in the top-5 bike-friendly cities in the world ❤️ www.paris.fr/pages/paris-...
Reposted by Nikos Konstantinides
Call for junior or mid-career group leaders in neuroscience! Apply by 30 Jan to join the FENS-Kavli Network. We are looking for excellent and engaged future scholars who are committed to exchanging scientific ideas & improve neuroscience in Europe. fenskavlinetwork.org/who-we-are/a...
November 17, 2025 at 11:21 AM
Call for junior or mid-career group leaders in neuroscience! Apply by 30 Jan to join the FENS-Kavli Network. We are looking for excellent and engaged future scholars who are committed to exchanging scientific ideas & improve neuroscience in Europe. fenskavlinetwork.org/who-we-are/a...
Fellow neuroscientists, consider applying and reach out if you have any questions! fenskavlinetwork.org/who-we-are/a...
November 17, 2025 at 9:31 AM
Fellow neuroscientists, consider applying and reach out if you have any questions! fenskavlinetwork.org/who-we-are/a...
Reposted by Nikos Konstantinides
Junior or mid-career group leaders working in neuroscience, apply by 30 Jan to join the FENS-Kavli Network! We are looking for excellent and engaged future scholars, committed to exchanging scientific ideas & contributing to improve Neuroscience in Europe. rb.gy/havqur
Application procedure – FKNE
rb.gy
November 17, 2025 at 9:19 AM
Junior or mid-career group leaders working in neuroscience, apply by 30 Jan to join the FENS-Kavli Network! We are looking for excellent and engaged future scholars, committed to exchanging scientific ideas & contributing to improve Neuroscience in Europe. rb.gy/havqur
This👇is a balanced view
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 8, 2025 at 7:48 PM
This👇is a balanced view
“Send it to Current Bio”
If someone told you: "I'm doing a study featuring lichen, drones and #dinosaur bones" What would you say?
www.cell.com/current-biol...
www.cell.com/current-biol...
Remote sensing of lichens with drones for detecting dinosaur bones
Brian Pickles and colleagues show that exposed dinosaur bones can be remote sensed
with drones by virtue of colored lichens growing on them.
www.cell.com
November 5, 2025 at 2:54 PM
“Send it to Current Bio”
Reposted by Nikos Konstantinides
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
It's 2025. The world is going to shit and, in Greece, people get killed over football teams. A sense of despair not only about the present but also about the future.
November 4, 2025 at 8:44 AM
It's 2025. The world is going to shit and, in Greece, people get killed over football teams. A sense of despair not only about the present but also about the future.
Reposted by Nikos Konstantinides
50 years ago, King & Wilson published a foundational paper that underlies the cis-regulatory paradigm (CRP) of #DevoEvo #EvoDevo, i.e., that *almost* all morphological evolution is driven by mutations in regulatory elements, rather than proteins, and it all arose from simple misunderstanding 🧪 🧵
October 29, 2025 at 12:35 AM
Reposted by Nikos Konstantinides
🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination
Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium , elimination of transposable ele...
doi.org
October 21, 2025 at 2:46 PM
🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
Reposted by Nikos Konstantinides
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Distinct mechanisms decommission redundant enhancers to facilitate phenotypic evolution
The evolutionary loss of morphological traits is often driven by changes in gene regulation. Many developmental genes are controlled by multiple, redundant enhancers, raising the question of how robus...
www.biorxiv.org
October 28, 2025 at 8:06 PM
Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nikos Konstantinides
Preparations for the next JEDI meeting are underway! The upcoming Junior European #Drosophila Investigator / #NewPI meeting is planned for Portugal in June. Final dates and additional details will be announced soon - stay tuned for updates!
October 28, 2025 at 10:14 PM
Preparations for the next JEDI meeting are underway! The upcoming Junior European #Drosophila Investigator / #NewPI meeting is planned for Portugal in June. Final dates and additional details will be announced soon - stay tuned for updates!
Reposted by Nikos Konstantinides
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
#JobOffer
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod
➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...
October 28, 2025 at 1:51 PM
Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!
Reposted by Nikos Konstantinides
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 5:25 PM
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
Aabel Aaberg and Zyra Zywiec are celebrating!
Hilariously bad idea. In my subfield author lists are almost always alphabetical!
🧪For those of us who do complex collaborations with multiple corresponding authors this is terrible . I suspect it will also hit female authors disproportionately as they tend to have more collaborations across fields…https://www.nature.com/articles/d41586-025-03281-4
October 26, 2025 at 6:04 PM
Aabel Aaberg and Zyra Zywiec are celebrating!
Reposted by Nikos Konstantinides
New preprint led by the brilliant @aleksandra-marconi.bsky.social on cichlid brain diversification, fgf8a signalling and regulatory divergence with TEs on the mix! All part of a wonderful collaboration with @ebablab.bsky.social
www.biorxiv.org/content/10.1...
@camzoology.bsky.social
www.biorxiv.org/content/10.1...
@camzoology.bsky.social
October 24, 2025 at 8:45 PM
New preprint led by the brilliant @aleksandra-marconi.bsky.social on cichlid brain diversification, fgf8a signalling and regulatory divergence with TEs on the mix! All part of a wonderful collaboration with @ebablab.bsky.social
www.biorxiv.org/content/10.1...
@camzoology.bsky.social
www.biorxiv.org/content/10.1...
@camzoology.bsky.social
In Donostia, teaching myself some Basque
October 24, 2025 at 12:53 PM
In Donostia, teaching myself some Basque
Reposted by Nikos Konstantinides
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms
academic.oup.com
October 17, 2025 at 11:58 AM
Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...
Reposted by Nikos Konstantinides
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity
Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...
www.biorxiv.org
October 16, 2025 at 12:34 PM
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Reposted by Nikos Konstantinides
I'm looking to recruit a post-doc to help push forward our growing interests in insect ecotoxicology.
Apply here by Nov 30th!
(thanks for reposting)
career5.successfactors.eu/sfcareer/job...
Apply here by Nov 30th!
(thanks for reposting)
career5.successfactors.eu/sfcareer/job...
Career Opportunities: Posdoctoral researcher in toxin susceptibility and evolution of resistance in insects (22517)
career5.successfactors.eu
October 16, 2025 at 12:18 PM
I'm looking to recruit a post-doc to help push forward our growing interests in insect ecotoxicology.
Apply here by Nov 30th!
(thanks for reposting)
career5.successfactors.eu/sfcareer/job...
Apply here by Nov 30th!
(thanks for reposting)
career5.successfactors.eu/sfcareer/job...
Reposted by Nikos Konstantinides
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....
Male CNS Connectome
A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...
www.janelia.org
October 5, 2025 at 3:40 PM
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....