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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · 24d

And a big thank you to both the examiners, Prof Mike Johnson and Dr Lasse Sinkkonen.

Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · 24d

Extremely proud of Dr Janis Transfeld, who defended her PhD. Janis' project was a heroic undertaking to profile the epigenome of in vivo human dopaminergic neurons, which she then leveraged to interpret Parkinson's risk variants. @jaenice.bsky.social @ukdri.ac.uk @imperialbrains.bsky.social 🎉🎓🍾

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Reposted by Alexi Nott 🏳️‍🌈

Sarah Marzi @sj-marzi.bsky.social · May 1

Really nice work from the @nottalexi.bsky.social lab using functional genomics to show that genetic risk for multiple neurodegenerative diseases is linked to disease-specific microglial pathways. Congrats Aydan, @mangiruben.bsky.social and Alexi 👏🏻✨

Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · May 1

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · May 1

Thank you Hyejun!

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · May 1

A first first-author paper by Aydan Askarova with @mangiruben.bsky.social & @sj-marzi.bsky.social showing that genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathways. @ukdri.ac.uk 🎉 🍾
journals.plos.org/plosgenetics... More to come from Aydan soon!

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Reposted by Alexi Nott 🏳️‍🌈

Sarah Marzi @sj-marzi.bsky.social · Apr 28

Many thanks to the excellent team on this, including @kittybmurphy.bsky.social , Yuqian Ye, Maria Tsalenchuk and @nottalexi.bsky.social 🙏🏻🙏🏻

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Reposted by Alexi Nott 🏳️‍🌈

Towfique Raj @trajnp.bsky.social · Mar 4

Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social

www.nature.com/articles/s41...

(Collaborative work with Panos Roussos and his team! )

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

www.nature.com

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Apr 14

@sj-marzi.bsky.social @annamallach.bsky.social @andreaserio.bsky.social

Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Apr 14

Wonderful evening with @liddelowsa.bsky.social following his visit to @imperialbrains.bsky.social @ukdri.ac.uk 🧠

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Reposted by Alexi Nott 🏳️‍🌈

Fusion Conferences @fusionconf.bsky.social · Apr 10

@nottalexi.bsky.social we are looking forward to your presentation at #Neuroepi25 in Malta.🌞
Please share with your followers to let them know early bird registration & talk submission closes on 24 April 2025!
Find out more: bit.ly/42ls1an
#FusionNeuro

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Reposted by Alexi Nott 🏳️‍🌈

Sarah Marzi @sj-marzi.bsky.social · Mar 27

Massive congrats and gratitude to lead authors Leyla Abbasova, Paulina Urbanaviciute, Di Hu and Joy Ismail, as well as collaborators Brian Schilder, @nottalexi.bsky.social and Nathan Skene 🙏🏻🥰 It's been a long journey, but I'm so glad I got to share it with these excellent colleagues!

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Reposted by Alexi Nott 🏳️‍🌈

Mikhail Spivakov @mspivakov.bsky.social · Mar 20

Postdoc position #1 is live! Please apply / spread the word!

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences

Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

lms.mrc.ac.uk

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Mar 4

Thank you for the invite, it was great to hear about the amazing science being done in the centre during my visit!

@OxfordPDCentre @oxfordpdcentre.bsky.social · Mar 3

Thank you to @ukdri.ac.uk Group Leader @nottalexi.bsky.social for joining us today & for his great talk on ‘The Epigenome of brain cell types and associations with disease’ @kavlioxford.bsky.social @oxforddpag.bsky.social @sophielfarrow.bsky.social @wademartinslab.bsky.social

Bluesky

forddpag.bsky.social

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Feb 14

We are missing you already!

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Reposted by Alexi Nott 🏳️‍🌈

Alessia Caramello @alessianeuro.bsky.social · Feb 14

Last day @ukdri.ac.uk @imperialbrains.bsky.social before starting my maternity leave 🍼 I will only briefly come back before heading to Turin for a new adventure 🇮🇹 Millions thanks to this bunch of people who supported me through these last 4 intense years! 💙🙏

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Jan 14

Big congrats!

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Reposted by Alexi Nott 🏳️‍🌈

Alexander Haglund @haglunda.bsky.social · Jan 14

Very excited to share our latest publication in @NatureGenet! Our manuscript shows how Mendelian Randomization (MR) isolates putatively causal links between cell-type specific gene expression & brain phenotypes.
www.nature.com/articles/s41...

Tweetorial below 👇

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Dec 13

Special thanks to @kevincziegler.bsky.social, Tomas Solomon, Isidora Gocmanac and everyone who helped put the evening together!

Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Dec 13

Happy holidays from the Neurogenomics groups at Imperial with the @sj-marzi.bsky.social and Skene labs ☃️. We had a wonderful evening of Nepalese food, quizzes and an epigenetics-inspired sip and paint 🎨🍷🧬

Picture of the Nott, Marzi and Skene labs taking Gen-Z style

Picture of Nott, Marzi and Skene lab after the sip and paint

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Reposted by Alexi Nott 🏳️‍🌈

Sarah Marzi @sj-marzi.bsky.social · Dec 11

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...

Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states

Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o

academic.oup.com

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Dec 8

Looking forward to another amazing Neuroepigenomics meeting, held in Malta this coming year!

Fusion Conferences @fusionconf.bsky.social · Dec 3

🌟 SAVE THE DATE! 🌟
The 4th Neuroepigenetics & Neuroepitranscriptomics Conference is back! 🎉
Join us in sunny St Julians, Malta, with chairs Hongjun Song (University of Pennsylvania) and Li-Huei Tsai (MIT)! ☀️
💥 Stay updated—sign up here: bit.ly/41ibKUS

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Reposted by Alexi Nott 🏳️‍🌈

Marija Kundakovic @kundakoviclab.bsky.social · Nov 25

OK, I've made a Starter Pack on Neuroepigenetics, Chromatin, and Gene Regulation! Please share and let me know who else should be added to this list.
go.bsky.app/6LWE4dr

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Nov 25

Thanks!

Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Nov 25

News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....

Spatial mapping of Alzheimer’s disease across genetic subtypes - Nature Genetics

Alzheimer’s disease is a complex, heterogeneous disorder with multiple genetic subtypes. Spatial and single-cell gene expression analyses of these subtypes have provided new insights into general and ...

www.nature.com

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Alexi Nott 🏳️‍🌈 @nottalexi.bsky.social · Nov 19

You are very quick, I just signed up on the weekend 😆 Thank you!

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