Russia is a terrorist state!

Preprint alert: Putative phages with dsRNA genomes. Intriguing what bacteria they may infect. Nature’s diversity continues to astonish! www.biorxiv.org/content/10.1...

The Russian spelling and pronunciation of Kyiv throughout the ages was no accident. While the name gets its origin from an empire that predates Russia, a series of policies by the Russian Empire and the Soviet Union that sought to Russify Ukraine and the Ukrainian language distorted its roots.

I’m very fortunate to be at the 2025 CRISPR Meeting in Christchurch to share our latest work on the quirky Cas12a diversity. What an amazing crowd and location!
@crisprmeeting.bsky.social

The diversity of microbial defenses is amazing! Type IV Thoeris system shows an ancient innate immunity mechanism which uses a TIR protein to make N7-cADPR, activating a caspase-like protease to block phages. Learn more: www.science.org/doi/10.1126/...

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems

Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...

Das Ende einer Ära: Heute fand die allerletzte Klasse in meinem geliebten Yogastudio statt, das mir in den letzten sechs Jahren ein Zufluchtsort war. Danke, Clau, für all die Posen und erholsamen Savasanas.

This is just wild: using AI-driven structural predictions, this study discovered how a phage-encoded “Cas12 hacker” hijacks the bacterial host’s thioredoxin enzyme to supercharge its DNA-cleaving ability. www.biorxiv.org/content/10.1...

An excellent review on direct Nanopore sequencing of RNA for detecting epigenetic modifications. We are clearly just at the beginning of this journey, with many exciting discoveries to come. www.sciencedirect.com/science/arti...

🧬 Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 👉 https://www.sisb2025.conferences-pasteur.org/home

An excellent review on nucleic acid recognition in microbial immunity! www.cell.com/molecular-ce...

Hanging there! Hoping to post my next printing here too, soon!

What a fantastic lineup! I really hope to be there to soak in all the amazing science of microbial defenses!

Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!

www.sisb2025.conferences-pasteur.org/home

Joins us in Institut Pasteur, Paris, April 8-10th.

Thank you for the insightful lecture on the role of RANK/L in bone remodeling, mammary gland development, and cancer therapeutics! Excited to see how the future of HZI takes shape!

Happy 🦃 day, everyone!

Congratulations @grunewald.bsky.social! It is an impressive accomplishment, showing how AI-designed binders can transform CAR-T therapies for resistant cancers!

🕯️