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Oncogenesis @oncogenesisnature.bsky.social · 6h

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 6h

In my role as AE for Oncogenesis, I look for translation potential and solid experimental work in a manuscript. I believe such studies are key to advancing science as well as cancer care.

–Maarten

Delighted to have him on our team at #Oncogenesis! 🤝

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Oncogenesis @oncogenesisnature.bsky.social · 6h

But also aim to ascertain efficacy from novel interventions or stratification modalities in early phase clinical studies.

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Oncogenesis @oncogenesisnature.bsky.social · 6h

We focus on tumor cell plasticity, the tumor microenvironment, and inter- and intratumor heterogeneity. We apply patient-derived preclinical models, gene expression profiling and wetlab experimental work.

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Oncogenesis @oncogenesisnature.bsky.social · 6h

🧬 Meet One of Our Associate Editors: Maarten Bijlsma

I am the scientific director of the Cancer Center Amsterdam, Amsterdam UMC, and professor of Experimental Gastrointestinal Oncology. My group is trying to find out why pancreatic and esophageal cancers are so hard to treat effectively.

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Oncogenesis @oncogenesisnature.bsky.social · 2d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 2d

Check how their study uncovers a novel cytoplasmic role of BRCA1 in regulating ER-associated protein stability via a non-canonical DNA damage response pathway and highlights mRNA stability and ER calcium signalling as potential therapeutic targets to overcome chemoresistance.

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Oncogenesis @oncogenesisnature.bsky.social · 2d

“Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay”

🔵 Guo Chen latest research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 7d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 7d

Check how authors, through the integration of bioinformatics techniques and experimental validation, show that NAC1 activates LDHA expression through transcription and suppresses CD8 + T cells, thus inducing HBV immune escape and ultimately promoting the occurrence of liver cirrhosis and HCC.

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Oncogenesis @oncogenesisnature.bsky.social · 7d

"NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development”

🔷Outstanding research from Lisheng Wang is now available to read in #Oncogenesis

▶️Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 9d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 9d

Check how the ability of ONC201 to overcome cisplatin resistance and its synergistic antitumor effects highlight its promise as a candidate for combination therapy.

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Oncogenesis @oncogenesisnature.bsky.social · 9d

“ONC201 enhances the cytotoxic effect of cisplatin through ATF3/ATF4/CHOP in head and neck squamous cell carcinoma cells”

🔵 Interesting research led Ming-Huei Chou has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 14d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 14d

Check how their findings suggest that cancer cells exhibiting high expression of centromere protein F (CENPF) play a central role in orchestrating the malignant evolution of LUAD and hold potential as a novel biomarker for early-stage detection and management of the disease.

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Oncogenesis @oncogenesisnature.bsky.social · 14d

“CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma”

🔵 Tao Jiang’s groundbreaking research appeared in #Oncogenesis

▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 16d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 16d

Check how the authors uncovered a previously under-characterized role of the SRCAP-1879 truncating mutation in driving multiple aspects of epithelial cancer progression, including invasion.

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Oncogenesis @oncogenesisnature.bsky.social · 16d

“A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression”

🔵 Xiaomin Bao latest and outstanding research is now available to read in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 21d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 21d

Check how these findings elucidate the pivotal role of RIOK3 in the cellular response to glucose deprivation, demonstrating its capacity to enhance IDH1 expression and NADPH generation in an HSP90α-dependent manner.

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Oncogenesis @oncogenesisnature.bsky.social · 21d

“RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway”

🔵 Interesting research led by Shengtao Zhu has been featured in #Oncogenesis.

▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 23d

@jer-06.bsky.social

Oncogenesis @oncogenesisnature.bsky.social · 23d

Check how their findings indicates that BRG1 regulates PKM2 Y105 phosphorylation and oligomeric state by enhancing the interaction between SHP1 and PKM2, and that BRG1 modulates glycolysis in NSCLC cells through the BRG1/SHP1/PKM2 Y105 pathway.

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